Relative apparent diffusion coefficient (rADC) in breast lesions of uncertain malignant potential (B3 lesions) and pathologically proven breast carcinoma (B5 lesions) following breast biopsy

Nadrljanski, Mirjan; Milošević, Zorica

doi:10.1016/j.ejrad.2020.108854

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…In both the protocol optimization study and the prone‐to‐supine comparison, all ADC measurements in fibroglandular tissue fell within the ranges previously reported for fibroglandular tissue in the breast 17,36 . All lesion ADCs also fell within ranges previously reported for those lesions 17,37,38 . Although only a very small number of lesions were analyzed in this study, the high correlation between lesion ADCs in the prone and supine position is notable, as a number of factors may be expected to affect the measurement differently in the two positions, including motion, gradient nonlinearity, cardiac aliasing artifact, and impacts of the difference in position on the diffusion properties of the tissue itself.…”

Section: Discussionsupporting

confidence: 79%

“…17,36 All lesion ADCs also fell within ranges previously reported for those lesions. 17,37,38 Although only a very small number of lesions were analyzed in this study, the high correlation between lesion ADCs in the prone and supine position is notable, as a In these four cases, the supine image has a higher rating for the three features (sharpness, aliasing, overall image quality) for which the difference between the two positions reached statistical significance, as well as for perceived SNR, which was not significantly different between the positions. Although distortion was also not found to be significantly different between the two positions, it is the only feature in these four cases for which prone is rated higher than supine.…”

Section: Discussionmentioning

confidence: 90%

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Multishot Diffusion‐Weighted MRI of the Breasts in the Supine vs. Prone Position

Moran

Middione

Mazzoli

et al. 2022

Magnetic Resonance Imaging

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Background Diffusion‐weighted imaging (DWI) may allow for breast cancer screening MRI without a contrast injection. Multishot methods improve prone DWI of the breasts but face different challenges in the supine position. Purpose To establish a multishot DWI (msDWI) protocol for supine breast MRI and to evaluate the performance of supine vs. prone msDWI. Study Type Prospective. Population Protocol optimization: 10 healthy women (ages 22–56), supine vs. prone: 24 healthy women (ages 22–62) and five women (ages 29–61) with breast tumors. Field Strength/Sequence 3‐T, protocol optimization msDWI: free‐breathing (FB) 2‐shots, FB 4‐shots, respiratory‐triggered (RT) 2‐shots, RT 4‐shots, supine vs. prone: RT 4‐shot msDWI, T2‐weighted fast‐spin echo. Assessment Protocol optimization and supine vs. prone: three observers performed an image quality assessment of sharpness, aliasing, distortion (vs. T2), perceived SNR, and overall image quality (scale of 1–5). Apparent diffusion coefficients (ADCs) in fibroglandular tissue (FGT) and breast tumors were measured. Statistical Tests Effect of study variables on dichotomized ratings (4/5 vs. 1/2/3) and FGT ADCs were assessed with mixed‐effects logistic regression. Interobserver agreement utilized Gwet's agreement coefficient (AC). Lesion ADCs were assessed by Bland–Altman analysis and concordance correlation (ρc). P value <0.05 was considered statistically significant. Results Protocol optimization: 4‐shots significantly improved sharpness and distortion; RT significantly improved sharpness, aliasing, perceived SNR, and overall image quality. FGT ADCs were not significantly different between shots (P = 0.812), FB vs. RT (P = 0.591), or side (P = 0.574). Supine vs. prone: supine images were rated significantly higher for sharpness, aliasing, and overall image quality. FGT ADCs were significantly higher supine; lesion ADCs were highly correlated (ρc = 0.92). Data Conclusion Based on image quality, supine msDWI outperformed prone msDWI. Lesion ADCs were highly correlated between the two positions, while FGT ADCs were higher in the supine position. Evidence Level 2. Technical Efficacy Stage 1.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 90%

Multishot Diffusion‐Weighted MRI of the Breasts in the Supine vs. Prone Position

Moran

Middione

Mazzoli

et al. 2022

Magnetic Resonance Imaging

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“…However, the results of this study were also higher than those of many studies results probably as they used the minimum ADC and r ADC values while the others and we used mean ADC and r ADC values [25,26]. Nadrljanski and Milosevic [30] published a research, the matched female premenopausal patients with confirmed histological diagnosis of either BIRADS 3 or BIRADS 5 lesions. They reported the selected pa-…”

Section: Discussionmentioning

confidence: 64%

Comparison of apparent diffusion coefficient and relative apparent diffusion coefficient values for differential diagnosis of breast lesions

PARLAK

Yagci

2022

The European Research Journal

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Objectives:The purpose the study was to evaluate the role of diffusion weighted magnetic resonance imaging (DW-MRI) in diagnosis of benign and malignant breast lesions, to calculate a cut-off apparent diffusion coefficient (ADC) value and to explore use of relative ADC (r ADC) for improving sensitivity and specificity of MRI in diagnosis of breast cancer. Methods: This retrospective study based on a cohort of patients who underwent dynamic contrast enhanced (DCE)-MRI having suspicious breast mass by ultrasonography and mammography to whom DWI sequence was added to the routine diagnostic MRI. ADC and r ADC (lesion/normal breast tissue) values of breast masses were calculated. The threshold ADC values used to differentiate benign and malignant lesions were determined using receiver operating characteristic analysis, sensitivity, specificity, positive predictive value and negative predictive value were calculated. Results: Malignant masses had significantly lower ADC (mean: 1.03 ± 0.36 × 10 -3 mm 2 /s) and r ADC (mean: 0.66 ± 0.22 × 10 -3 mm 2 /s) values than those of benign masses with ADC (mean: 1.50 ± 0.56 × 10−3 mm 2 /s) and r ADC (mean: 0.97 ± 0.31 × 10 -3 mm 2 /s) values, respectively (p = 0.001 for both). The best cut-off value for the lesion ADC was 1.09 × 10 -3 mm 2 /s with a sensitivity of 72.73%, and specificity of 79.17%. The best cut-off value for r ADC was 0.83 with sensitivity of 78.79% and specificity of 70.83%. Conclusions: DWI has high diagnostic value with high sensitivity and specificity differentiating benign and malignant breast lesions. ADC and r ADC values can improve the diagnostic accuracy of differentiating benign and malignant breast lesions.

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“…12,14 In addition, the value of the diffusion-weighted imaging (DWI) ratio in distinguishing the malignant potential of breast malignancies and for estimating the prognosis of glioblastoma after radiotherapy has been demonstrated. 15,16 These studies suggested that the DKI ratio was expected to be a reliable imaging marker for the preoperative diagnosis of MIBC. However, the potential of the DKI ratio to distinguish MIBC from NMIBC and whether it has a complementary role to VI-RADS in the diagnosis of MIBC have not been fully studied.…”

mentioning

confidence: 99%

“…Previous studies have shown that the ratio of diffusion parameters of the lesion to the reference tissue can help to standardize diffusion parameters, thereby reducing their deviation from accurate diffusion parameter 12,14 . In addition, the value of the diffusion‐weighted imaging (DWI) ratio in distinguishing the malignant potential of breast malignancies and for estimating the prognosis of glioblastoma after radiotherapy has been demonstrated 15,16 . These studies suggested that the DKI ratio was expected to be a reliable imaging marker for the preoperative diagnosis of MIBC.…”

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confidence: 99%

Detecting Muscle Invasion of Bladder Cancer: An Application of Diffusion Kurtosis Imaging Ratio and Vesical Imaging‐Reporting and Data System

Qin,

Tian,

Zhou

et al. 2023

Magnetic Resonance Imaging

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BackgroundIndependent factors are needed to supplement vesical imaging‐reporting and data system (VI‐RADS) to improve its ability to identify muscle invasive bladder cancer (MIBC).PurposeTo assess the correlation between MIBC and diffusion kurtosis imaging (DKI) ratio, VI‐RADS, and other factors (such as tumor location).Study TypeRetrospective.PopulationSixty‐eight patients (50 males and 18 females; age: 70.1 ± 9.5 years) with bladder urothelial carcinoma.Field Strength/Sequence1.5 T, conventional diffusion‐weighted imaging (DWI), and DKI (single shot echo‐planar sequence).AssessmentThree radiologists independently measured the diffusion parameters of each bladder cancer (BCa) and obturator internus, including the mean apparent diffusion coefficient (ADCmean), mean kurtosis (MK), and mean diffusion (MD). And the ratio of diffusion parameters between BCa and obturator internus was calculated (diffusion parameter ratio = bladder cancer:obturator internus). Based on the VI‐RADS, the target lesions were independently scored. Furthermore, the actual tumor‐wall contact length (ACTCL) and absolute tumor‐wall contact length (ABTCL) were measured.Statistical TestsMulticollinearity among independent variables was evaluated using the variance inflation factor (VIF). Multivariable logistic regression analysis was used to determine the independent risk factors of MIBC. The receiver operating characteristic curve was used to evaluate the efficacy of each variable in detecting MIBC. The DeLong test was used to compare the area under the curve (AUC). A P < 0.05 was considered statistically significant.ResultsMKratio (median: 0.62) and VI‐RADS were independent risk factors for MIBC. AUCs for MKratio, VI‐RADS, and MKratio combined with VI‐RADS in assessing MIBC were 0.895, 0.871, and 0.973, respectively. MKratio combined with VI‐RADS was more effective in diagnosing MIBC than VI‐RADS alone.Data ConclusionsMKratio has potential to assist the assessment of MIBC. MKratio can be used as a supplement to VI‐RADS for detecting MIBC.Level of Evidence4Technical EfficacyStage 2

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Relative apparent diffusion coefficient (rADC) in breast lesions of uncertain malignant potential (B3 lesions) and pathologically proven breast carcinoma (B5 lesions) following breast biopsy

Cited by 6 publications

References 17 publications

Multishot Diffusion‐Weighted MRI of the Breasts in the Supine vs. Prone Position

Multishot Diffusion‐Weighted MRI of the Breasts in the Supine vs. Prone Position

Comparison of apparent diffusion coefficient and relative apparent diffusion coefficient values for differential diagnosis of breast lesions

Detecting Muscle Invasion of Bladder Cancer: An Application of Diffusion Kurtosis Imaging Ratio and Vesical Imaging‐Reporting and Data System

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