Relative Analgesic Potencies of Ropivacaine and Bupivacaine for Epidural Analgesia in Labor

Polley, Linda S.; Columb, Malachy O.; Naughton, Norah N.; Wagner, Deborah; Ven, Cosmas J. M. van de

doi:10.1097/00000542-199904000-00003

Cited by 393 publications

(43 citation statements)

References 24 publications

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“…Studies of the minimum local analgesic concentration with respect to the relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labour have found ropivacaine to be 40% less potent than bupivacaine [8,9]. These results are in agreement with a study that compared the intrathecal administration of the two local anaesthetics [10].…”

supporting

confidence: 82%

Ropivacaine and bupivacaine in obstetric analgesia

Capogna¹

2002

EJA

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supporting

confidence: 82%

Ropivacaine and bupivacaine in obstetric analgesia

Capogna¹

2002

EJA

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“…†Statistically significant compared to groups LF and LC, p < 0.05. bupivacaine at the ED 50 point of the dose-response curve [12,13]. The obvious explanation is that the less potent levobupivacaine 0.1% up to 15 ml.h )1 is insufficient for postoperative paravertebral analgesia after breast surgery.…”

Section: Discussionmentioning

confidence: 99%

Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery

Burlacu¹,

Frizelle

Moriarty

et al. 2006

Anaesthesia

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SummaryThe addition of fentanyl or clonidine to levobupivacaine was evaluated in patients undergoing breast surgery under general anaesthesia with intra-and postoperative paravertebral analgesia. Patients were randomly allocated to four groups: Group L received 19 ml bolus levobupivacaine 0.25% plus 1 ml saline followed by an infusion of levobupivacaine 0.1%; Group LF received 19 ml bolus levobupivacaine 0.25% plus fentanyl 50 lg followed by an infusion of levobupivacaine 0.05% with fentanyl 4 lg.ml )1 ; Group LC received 19 ml bolus levobupivacaine 0.25% plus clonidine 150 lg followed by an infusion of levobupivacaine 0.05% with clonidine 3 lg.ml

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“…Bupivacaine and ropivacaine have already been studied in various regional blockade techniques. In this study, the total dose and concentration of bupivacaine were selected from previous studies [14]- [17], all of which showed the efficacy of plain bupivacaine in concentrations ranging from 0.25% to 0.5%. Effectiveness of bupivacaine has been shown previously in control of thoracotomy pain [17] [18] but there are no studies to determine recommended concentrations of bupivacaine would provide better pain control in sternotomy pain without toxicity.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Parasternal Intercostal Block Using Ropivacaine or bupivacaine for Postoperative Analgesia in Patients Undergoing Cardiac Surgery

Saini¹,

Chauhan²,

Kiran³

et al. 2015

WJCS

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Objective: The objective of this study was to compare the efficacy of 0.5% ropivacaine and 0.25% bupivacaine for parasternal intercostal block for postoperative analgesia in children undergoing cardiac surgery. Design: A randomized, controlled, prospective, double blind study. Setting: A tertiary care teaching hospital. Participants: One Hundred children scheduled for cardiac surgery through a median sternotomy were divided into 3 groups of at least 33 children each, receiving either ropivacaine, bupivacaine or saline (control). Interventions: A bilateral parasternal block performed either with 0.5% ropivacaine or 0.25% bupiacaine or 0.9% saline with 5 doses of 0.5 mL on each side in the 2nd to 6th parasternal intercostal spaces 1 to 1.5 cm lateral to the sternal edge, before sternal wound closure. Measurements and Main Results: The time to extubation was significantly less in children administered the parasternal blocks with ropivacaine or bupivacaine compared to the saline (control) group. The pain scores were lower and comparable in the ropivacaine and bupivacaine groups compared to the saline group. The cumulative fentanyl dose requirement over a 24-hour period was higher in the saline group than the ropivacaine (p < 0.001) and bupivacaine group. No side effects were observed in any of the children. Conclusions: Parasternal blocks either with ropivacaine or bupivacaine appear to be a simple, safe, and useful technique for supplementation of postoperative analgesia in children undergoing cardiac surgery with a median sternotomy.

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Relative Analgesic Potencies of Ropivacaine and Bupivacaine for Epidural Analgesia in Labor

Abstract: Ropivacaine was significantly less potent than bupivacaine for epidural analgesia in the first stage of labor.

Cited by 393 publications

References 24 publications

Ropivacaine and bupivacaine in obstetric analgesia

Ropivacaine and bupivacaine in obstetric analgesia

Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery

Comparison of Parasternal Intercostal Block Using Ropivacaine or bupivacaine for Postoperative Analgesia in Patients Undergoing Cardiac Surgery

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