Relative Analgesic Potencies of Levobupivacaine and Ropivacaine for Epidural Analgesia in Labor

Polley, Linda S.; Columb, Malachy O.; Naughton, Norah N.; Wagner, Deborah

doi:10.1097/00000542-200209002-01052

Cited by 28 publications

(39 citation statements)

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“…The onset to the block was found to be between 4-5 mins and the complication rate of Hypotension (5%) and Bradycardia (3%) was much lower than its racemic compound Bupivacaine. [21][22][23] The interventions required in the study group was significantly lower than those required in the usage of Bupivacaine.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

2017

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Background: The aim of this study was to detect if intrathecal hyperbaric Levobupivacaine provided anaesthesia with more stable hemodynamic profile than 0.5% Hyperbaric Bupivacaine for lower limb and abdominal surgery.Methods: This observational study was carried out on 60 Adult patients between 18-65 Years of age, in ASA I and II undergoing lower abdominal surgery. Subarachnoid block using 3.0 ml of 0.5% hyperbaric Levobupivacaine (15 mg) was used as anaesthesia for surgery. Vitals recorded first in operation theatre were taken as baseline and were compared with subsequent readings till closure to judge the fall in blood pressure. Frequencies of parameters falling more than 30% from baseline, amount of IV fluids, vasopressors administered and complications were recorded. The data collected was displayed as mean with a standard deviation and frequency with percentage. Statistical analysis was performed using in stat computer software.Results: On analysis of the data it was found that fall in hemodynamic parameters was significantly lower in the Levobupivacaine group. It was observed that maximum onset of motor block was after 5 minutes, VAS after 4 minutes and loss of pinprick sensation was achieved at T-4 level after 4 minutes. Haemodynamic complications, which required therapeutic interventions, were hypotension (5%), bradycardia (3%), a total of 8%, who required urgent intervention as vasopressors and inotropes.Conclusions: 0.5% Hyperbaric Levobupivacaine, has onset of action similar to other local anaesthetics used for subarachnoid block, but has better hemodynamic profile in comparison to Hyperbaric 0.5% Bupivacaine, the commonly used local anaesthetic agent used for Spinal Anaesthesia.

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Section: Discussionmentioning

confidence: 99%

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

2017

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“…Parturientss who participated in this study received 0.25% bupivacaine (S75-R25) and 0.20% ropivacaine. Studies based on up-and-down sequential allocation method have demonstrated the lack of statistically significant differences in the minimal anesthetic concentration between levobupivacaine and ropivacaine 14,15 , besides suggesting that the latter is possibly less potent than racemic bupivacaine. However, other clinical studies comparing epidural racemic bupivacaine and ropivacaine in labor analgesia revealed contradictory results.…”

Section: Discussionmentioning

confidence: 99%

Estudo comparativo entre bupivacaína (S75-R25) e ropivacaína em bloqueio peridural para analgesia de parto

Nogueira

Lima²,

Paris³

et al. 2010

Rev. Bras. Anestesiol.

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Summary: Nogueira CS, Lima LC, Paris VC, Neiva PM, Otani ET, Couceiro RO, Burim F, Ferreira Junior JAF, Cadecaro P -A Comparative Study between Bupivacaine (S75-R25) and Ropivacaine in Spinal Anesthesia for Labor Analgesia. Background and objectives:Spinal anesthesia is used for relief of pain during labor and it is associated with low indices of complications. Studies with levorotatory enantiomers of local anesthetics demonstrate higher safety due to the lower cardiotoxicity. The objective of this study was to evaluate the latency and duration of analgesia and maternal and fetal repercussions with bupivacaine (S75-R25) and ropivacaine in spinal anesthesia for labor analgesia.

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“…In a study conducted by Kountoudi et al, where they compared epidural Levobupivacaine 0.5% with Ropivacaine 0.5% for inguinal hernia repair procedures in 30 patients, there was no difference as far as the level of sensory block is concerned. 17 In a study conducted by Finucane et al, where they compared different concentrations of Ropivacaine (0.5%, 0.75% and 1%) and Bupivacaine in concentration of 0.5% in 25 ml volume in patient undergoing lower abdominal surgeries with epidural anaesthesia, they observed no difference between the groups in terms of maximum sensory block level. 12 However when duration of motor and sensory blocks were compared, as the ropivacaine dose was increased, they obtained a significant dose response effect.…”

Section: Sensory and Motor Parametersmentioning

confidence: 96%

The efficacy of epidural ropivacaine 0.75% and levobupivacaine 0.5% in abdominal and lower limb surgeries- a comparative study

Kumar

Rao

2016

Int J Res Med Sci

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Relative Analgesic Potencies of Levobupivacaine and Ropivacaine for Epidural Analgesia in Labor

Cited by 28 publications

References 1 publication

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

Intraoperative haemodynamic profile in patients undergoing lower limb and abdominal surgery under subarachnoid block using 0.5% hyperbaric levobupivacaine: an observational study

Estudo comparativo entre bupivacaína (S75-R25) e ropivacaína em bloqueio peridural para analgesia de parto

The efficacy of epidural ropivacaine 0.75% and levobupivacaine 0.5% in abdominal and lower limb surgeries- a comparative study

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