Relationships of visual impairment and eye conditions with imaging markers, cognition, and diagnoses of dementia: a bi-directional Mendelian randomization study
Erin L Ferguson,
Mary Thoma,
Peter Buto
et al.
Abstract:ObjectiveTo evaluate the causal relationships between visual acuity, eye conditions (focusing on cataracts and myopia), and Alzheimer disease (AD) and related dementias.DesignCohort and two sample bi-directional mendelian randomization (MR) study.SettingUK Biobank participants and summary statistics from previously published genome-wide association studies on cataract, myopia, and AD.ParticipantsUK Biobank participants (n=304,953) aged 55-70 without dementia at baseline, underwent genotyping, reported on eye c… Show more
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