Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Li, Wei; Liu, Xiaojun; Liu, Lijun; Zhang, Lei; Li, Mengdi; Li, Rui; Li, Tianfang; Chen, En; Liu, Shengyun

doi:10.3389/fcvm.2022.824561

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…A series of studies have reported inverse associations between TG levels and bone turnover markers. [34][35][36] Li et al 34 found that hypertriglyceridaemia was negatively associated with N-MID osteocalcin, β-CTX and P1NP after adjusting for potential confounders, but no significant association was found between serum BTMs and HDL-C in patients with T2D, supporting our conclusion. Liu et al 35 reported that TG levels were negatively correlated with OC or β-CTX levels in young and middle-aged male patients with T2D.…”

supporting

confidence: 76%

Novel Associations of Dyslipidaemia with Vitamin D and Bone Metabolism in Elderly Patients with Diabetes: A Cross-Sectional Study

Zha,

Wang,

Zhou

et al. 2023

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Little is known about whether diabetic dyslipidaemia contributes to increased bone fragility in patients with diabetes. This study aimed to explore the potential effects of dyslipidaemia on vitamin D and bone metabolism in elderly subjects with type 2 diabetes (T2D). Methods: A total of 1479 male patients and 1356 female patients 50 years or older with T2D were included in Shanghai, China. Lipid profiles, 25-hydroxyvitamin D (25(OH)D), serum procollagen type I N-terminal propeptide (P1NP), β-C-terminal telopeptide (β-CTX) and other parameters were measured. Principal component regression (PCR) and mediation analysis were used to estimate the associations of lipid profile, 25(OH)D and bone turnover levels. Results: Female patients presented with higher blood lipids, lower 25(OH)D, and higher P1NP and β-CTX levels than male patients with T2D. TC was associated with P1NP in males and females (β=0.056, P<0.05; β=0.095, P<0.01, respectively), and 25(OH)D fully mediated the associations in males and mediated approximately 17.89% of the effects in females. LDL-C was associated with P1NP in males and females (β=0.072 and 0.105 respectively, all P<0.01), and 25(OH)D mediated the relationships approximately 20.83% in males and 14.29% in females. TG was negatively associated with P1NP (in males, β= −0.063, P<0.05; in females, β= −0.100, P<0.01) and β-CTX (in males, β= −0.108; in females, β= −0.128, all P<0.01) independent of 25(OH)D, while HDL-C was not associated with P1NP or β-CTX in diabetic patients. Conclusion: Hypercholesterolemia and hypertriglyceridaemia might affect bone metabolism by distinguishing pathways in diabetes patients. Ameliorating lipid control in elderly diabetes patients, especially female patients, will benefit both vitamin D and bone metabolism.Plain Language Summary: Diabetic dyslipidaemia may be one of the factors involved in increased bone fragility in diabetes. Currently, there have been few studies regarding the effects of dyslipidaemia on vitamin D and bone metabolism in diabetes. We aimed to explore the potential effects of dyslipidaemia on vitamin D and bone metabolism in elderly subjects with T2D. Thus, we conducted a cross-sectional study of 2835 adult T2D patients 50 years or older in Shanghai, China. Our study revealed that high levels of cholesterol and triglycerides might have detrimental effects on vitamin D metabolism and bone turnover by distinguishing pathways in elderly patients with T2D, and discrepancies exist between male and female patients. Ameliorating lipid control in elderly diabetes patients, especially female patients, will benefit both vitamin D and bone metabolism.

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supporting

confidence: 76%

Novel Associations of Dyslipidaemia with Vitamin D and Bone Metabolism in Elderly Patients with Diabetes: A Cross-Sectional Study

Zha,

Wang,

Zhou

et al. 2023

DMSO

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“…CRP is an important inflammatory mediator; when its levels are high, it can damage blood vessels and cause lipid deposition in the arterial intima, which leads to the occurrence of atherosclerosis (20). TNF-α, as a proinflammatory factor, can promote the secretion of IL-6, cause damage to endothelial cells, cause thrombosis, and lead to blood vessel stenosis and occlusion (21).…”

Section: Discussionmentioning

confidence: 99%

Effect of diabetes on the prognosis, serum inflammatory factors, and quality of life of patients with lower extremity arteriosclerosis obliterans after vascular intervention: a retrospective comparative cohort study

Zhao¹,

Zhuo²,

Hao³

et al. 2022

Ann Palliat Med

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Background: Lower extremity arteriosclerosis obliterans (LEASO) is a chronic progressive disease with clinical manifestations such as intermittent claudication, resting pain, and even ulceration or necrosis of the lower extremities caused by insufficient blood supply to the diseased limbs. This study aimed to evaluate the effect of diabetes on the prognosis of LEASO patients after the percutaneous transluminal angioplasty (PTA) treatment. Methods:The clinical data of LEASO patients who received PTA treatment in the Blood Hernia Minimally Invasive Surgery Ward of Xuzhou Central Hospital from January 2017 to December 2021 were retrospectively analyzed. The patients were divided into a diabetic group and a non-diabetic group. The general data, lesion location, technical and clinical success rates, changes in the ankle-brachial index (ABI) and serum inflammatory factors, perioperative complications, resting pain relief rate, amputation rate, and quality of life of the two groups were compared.Results: A total of 223 LEASO patients (256 limbs) were included, including 78 patients with diabetes (91 limbs) and 145 patients without diabetes (165 limbs). Compared with the non-diabetic group, the proportion of lesions in the superior genicular artery was lower, and that in the inferior genicular artery was higher in the diabetic group (P<0.05). Compared with the diabetic group, the levels of serum inflammatory factors in the non-diabetic group were significantly lower than those in the diabetic group, while the clinical success rate was markedly higher (P<0.05). Moreover, the body pain, general health, and mental health scores of the non-diabetic group were considerably higher than those of the diabetic group patients. Logistic regression analysis showed that the OR values of Rutherford stage, diabetes and C-reactive protein (CRP) level were 20.124, 44.893 and 14.523 respectively, P<0.05, which were independent factors affecting clinical success.Conclusions: PTA to treat diabetic patients with LEASO can achieve short-term efficacy similar to that of non-diabetic patients. However, the long-term clinical success rate and quality of life of diabetes patients are still inferior to those of non-diabetic patients. Standardized postoperative anti-inflammatory treatment and blood glucose control are crucial for long-term efficacy.

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“…[15][16][17] Serum level of OC was reported to be highly associated with T2DM risk, and OC was confirmed to be an independent factor for macrovascular complications in T2DM patients. 18,19 However, few comprehensive analyses have been performed to clarify the association of BTMs and MVCs with T2DM patients in China. BTMs are hypothesized to be potential biochemical indicators of hyperglycemia and microcirculatory dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Association of Bone Turnover Markers with Type 2 Diabetes Mellitus and Microvascular Complications: A Matched Case-Control Study

Hou¹,

Hou²,

Nie³

et al. 2023

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The aim of this study was to evaluate the association of bone turnover markers (BTMs) with type 2 diabetes mellitus (T2DM) and microvascular complications. Methods: A total of 166 T2DM patients and 166 non-diabetic controls matched by gender and age were enrolled. T2DM patients were subclassified into groups based on whether they had diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR), and diabetic kidney disease (DKD). Clinical data including demographic characteristics and blood test results [serum levels of osteocalcin (OC), N-terminal propeptide of type 1 procollagen (P1NP), and β-crosslaps (β-CTX)] were collected. Logistic regression and restrictive cubic spline curves were performed to examine the association of BTMs with the risk of T2DM and microvascular complications. Results: After adjusting for family history of diabetes, sex and age, an inverse association was observed between elevated serum OC levels [ORð95%CIÞ ¼ 0:18 0:09; 0:35 ð Þ, p < 0.001] and increased serum P1NP levels ORð95%CIÞ ¼ 0:23 0:12; 0:44 ð Þ, p < 0.001] with the risk of T2DM. Moreover, there was an inverse linear association of serum OC and P1NP levels with the risk of T2DM. However, β-CTX was not associated with T2DM. Further analysis showed a nonlinear association between OC and the risk of DR, while P1NP and β-CTX were not correlated with DR. Serum concentrations of BTMs were not associated with the risks of DPN and DKD. Conclusion: Serum OC and P1NP levels were negatively correlated with T2DM risk. Particularly, serum OC levels were associated with DR risk. Given that BTMs are widely used as markers of bone remodeling, the present finding provides a new perspective for estimating the risk of diabetic microvascular complications.

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Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus

Cited by 8 publications

References 38 publications

Novel Associations of Dyslipidaemia with Vitamin D and Bone Metabolism in Elderly Patients with Diabetes: A Cross-Sectional Study

Novel Associations of Dyslipidaemia with Vitamin D and Bone Metabolism in Elderly Patients with Diabetes: A Cross-Sectional Study

Effect of diabetes on the prognosis, serum inflammatory factors, and quality of life of patients with lower extremity arteriosclerosis obliterans after vascular intervention: a retrospective comparative cohort study

Association of Bone Turnover Markers with Type 2 Diabetes Mellitus and Microvascular Complications: A Matched Case-Control Study

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