Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (
            <i>p,p’</i>
            -DDE) with Testosterone Levels in Adolescent Males

Schell, Lawrence M.; Gallo, Mia V.; Deane, Glenn; Nelder, Kyrie R.; DeCaprio, Anthony P.; Jacobs, Agnes

doi:10.1289/ehp.1205984

Cited by 41 publications

(19 citation statements)

References 66 publications

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“…Also, direct measurements in children’s serum, rather than self-answered questionnaires of dietary intakes, might improve the validity of current exposures in children (Hoppin et al 2000; Karmaus and Zhu 2004). We assessed the associations among metabolic biomarkers, not only for specific compounds but also for mixtures of PCBs and OCPs, by summing individual chemicals to observe the combined toxic effects on the human body, as in other studies (Pan et al 2009; Schell et al 2014). This can also be a limitation, because we assumed that a given mixture was additive, disregarding other possible effects, such as synergism or antagonism.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7–9 Years: A Prospective Cohort Study

Park

Hong

et al. 2016

Environ Health Perspect

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Background:Persistent organic pollutants (POPs) are endocrine disruptors and have been suggested as possible risk factors for diabetes. Few studies have been performed to investigate this association among children.Objectives:In this study, we prospectively examined the relationship between the serum concentration of POPs and glucose metabolism in children.Methods:Data were collected from the Ewha Birth & Growth Cohort Study, an ongoing birth cohort study initially constructed between 2001 and 2006. In 2010–2012, the POP concentration was measured in serum from a total of 214 children, 7–9 years of age. Using fasting glucose and insulin measurements at both baseline and the second year of follow-up, the homeostatic model assessment of beta-cell function (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Multiple linear regression analysis and a linear mixed-effects model were used to determine the relationship between POP tertiles and metabolic biomarkers.Results:Compared with the lowest tertile of total marker PCBs, participants in the third tertile had decreased HOMA-β values, after adjustment for age, sex, body mass index z-score, mother’s education, ponderal index, and history of breastfeeding (–18.94%; 95% CI: –32.97%, –1.98%). In a linear mixed model, the HOMA-β values were still lower in subjects in the highest compared with the lowest tertile of total PCBs at the 2-year follow-up period (108.3 vs. 135.0, respectively).Conclusion:The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes.Citation:Park SH, Ha EH, Hong YS, Park H. 2016. Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: a prospective cohort study. Environ Health Perspect 124:1924–1930; http://dx.doi.org/10.1289/EHP147

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Section: Discussionmentioning

confidence: 99%

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7–9 Years: A Prospective Cohort Study

Park

Hong

et al. 2016

Environ Health Perspect

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“…A study of 120 Akwesasne Mohawk boys (aged 10–17 years) reported that concurrent measurements of p , p ′-DDT were not associated with testosterone (T) levels, although p , p ′-DDE levels were positively but not significantly associated (Schell et al 2014). The one previous study that examined the association of in utero exposure to DDT/DDE on the hormones of adolescent boys found no association between maternal prenatal levels during a time of peak use in the US and their sons’ T levels at ages 10 to 17 years (n=260) (Gladen et al 2004).…”

Section: Introductionmentioning

confidence: 99%

In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: The CHAMACOS study

Eskenazi

Rauch

Tenerelli

et al. 2017

International Journal of Hygiene and Environmental Health

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Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the relationship of in utero and childhood exposure to these purported EDCs and reproductive hormones in adolescent boys who participated in CHAMACOS, an ongoing birth cohort in California’s Salinas Valley. We measured o,p′- and p,p′-DDT, p,p′- DDE, PBDEs and PCBs in serum collected from mothers during pregnancy or at delivery and from their sons at 9 years. We measured concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (T) from 234 of their sons at 12 years. In adjusted models, we found that a 10-fold increase in maternal prenatal serum concentrations of BDE-153 was associated with a 22.2% increase (95% CI: 1.0, 47.9) in FSH, a 96.6% increase (95% CI: 35.7, 184.7) in LH, and a 92.4% increase (95% CI: 20.9, 206.2) increase in T. Similarly, BDE-100 concentrations were associated with increases in boys’ LH levels. A 10-fold increase in total prenatal ΣPCBs was associated with a 64.5% increase (95% CI: 8.6, 149.0) in FSH, primarily driven by non-dioxin-like congeners. Boys’ hormone levels were only marginally associated with prenatal DDT or DDE in primary models, but when boys’ Tanner stage at age 12 was added to models, prenatal maternal DDT levels were associated with decreases in LH (adjusted percent change per 10-fold increase = −18.5%, 95% CI: −29.8, −5.4) and T (percent change = −18.2%, 95% CI: −30.2, −4.2) and DDE with LH (percent change = −18.3%, 95% CI: −32.9, −0.6). Exposures measured in the children’s serum at 9 years also showed associations between BDE-153 and ΣPCBs. However, there is evidence that these associations appear to be mediated by child BMI. This study suggests associations on male hormones of 12 year old boys related to exposure to certain EDC exposure prenatally. The implications on future reproductive function in puberty and adulthood should be determined.

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“…Our results from earlier studies showing earlier sexual maturation in girls and reduced testosterone levels in boys in relation to certain toxicant levels suggested that toxicant levels needed to be considered as possible causes of women’s reproductive problems (Denham, et al 2005; Schell et al, 2014). Further, the study of Akwesasne women has relevance for AI/AN women generally owing to their greater exposure to environmental toxicants.…”

Section: Preliminary Results From the Reproductive Health Study At Akmentioning

confidence: 59%

Power and pollutant exposure in the context of American Indian health and survival

Schell

Gallo

Horton

2016

Annals of Human Biology

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American Indians and Alaskan Natives (AI/AN) are a highly diverse group in terms of culture and language but share a history of oppression and attempted extermination that has left many with a legacy of poverty and poor health. Cultural and biological survival are important issues for many AI/AN groups. Using US criteria, AI/AN groups are more likely to be poor. The US National Center for Health Statistics reports that US AI/ANs have higher mortality and morbidity rates than the US population. While all groups racially defined by the US National Center for Health Statistics are experiencing a decline in fertility since 1983, AI/ANs seem to be suffering a substantially greater and earlier decline in fertility. Given the importance of fertility in the survival of AI/AN communities, it is important to identify the source of this decline. A recent study of one AI/AN group living along the St. Lawrence River found that obesity and exposure to a particular group of polychlorinated biphenyls were the factors most highly associated with indicators of impaired fertility. Economic factors are often cited as reasons for fertility declines, however in this situation these other factors may have either primary or contributing roles. If the associations with obesity and toxicant exposure are confirmed, intervening on these factors might be important steps in stemming continued declines in fertility.

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Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene ( p,p’ -DDE) with Testosterone Levels in Adolescent Males

Cited by 41 publications

References 66 publications

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7–9 Years: A Prospective Cohort Study

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7–9 Years: A Prospective Cohort Study

In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: The CHAMACOS study

Power and pollutant exposure in the context of American Indian health and survival

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