Relationships of Lipoprotein Lipids to Mild Fasting Hyperglycemia and Diabetes in Pregnancy

Knopp, Robert H.; Chapman, Margaret B.; Bergelin, Robert O.; Wahl, Patricia W.; Warth, Maria R.; Irvine, Susan

doi:10.2337/diacare.3.3.416

Cited by 55 publications

(29 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The high levels of total cholesterol and triglycerides in GDM patients were observed previously (Meyers-Seifer and Vohr, 1996;Grundy et al, 2006;American Diabetes Association, 2010;Marcinkevage and Narayan, 2011) and are consistent with frequent association of GDM with lipid profile modifications (Knopp et al, 1980). The significantly higher levels of HDL cholesterol observed in GDM patients compared to controls was not observed in other studies (Grundy et al, 2006;American Diabetes Association, 2010;Marcinkevage and Narayan, 2011) that reported low HDL cholesterol levels in GDM patients of different populations.…”

Section: Discussionsupporting

confidence: 86%

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

Frigeri

Santos²,

Réa³

et al. 2012

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 86%

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

Frigeri

Santos²,

Réa³

et al. 2012

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Knopp and colleagues studied 22 wo men with GDM and 38 controls in the third trimester of pre gnancy (35). These authors found increased pla sma concentrations of triglycerides and VLDL-cho le sterol but no difference in plasma cholesterol concen tra tions in women with GDM (35). Montelo n go and collea gues in their study also reported no differences in total cholesterol and tri gly ceride between women with GDM and controls in their first, second or third tri mester (36).…”

Section: Discussionmentioning

confidence: 94%

“…The dysli pidaemia profile observed in our study is not in accordance with reports from some other investi ga tions. Knopp and colleagues studied 22 wo men with GDM and 38 controls in the third trimester of pre gnancy (35). These authors found increased pla sma concentrations of triglycerides and VLDL-cho le sterol but no difference in plasma cholesterol concen tra tions in women with GDM (35).…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia

McGrowder¹,

Grant²,

Irving³

et al. 2009

Journal of Medical Biochemistry

View full text Add to dashboard Cite

zna~ajno povi{en paritet (p=0,047), ukupni holesterol (p=0,039) i trigliceride (p=0,033), ali i nezna~ajno ni`i HDL-holesterol (p=0,086) u pore|enju sa kontrolom. Sistolni krvni pritisak bio je zna~ajno po vi{en kod `ena sa GDM u kombinaciji sa PE (GDM-PE; p=0,015), a prose~na te`ina novoro|en~adi koju su rodilè ene sa GDM-PE bila je zna~ajno ni`a nego kod `ena sa GDM (p=0,025). @ene sa GDM-PE imale su zna~ajno povi{ene trigliceride (p=0,020), i sklonije su ve}em broju trudno}a (p=0,047) uz zna~ajno povi{en VLDL-holesterol (p=0,037), u pore|enju sa `enama samo sa GDM. 11,9% ena sa GDM imalo je PE. Na osnovu tih nalaza mo`e se zaklju~iti da je GDM povezan sa hiperlipidemijom, {to se vidi iz zna~ajno povi{enih ukupnih koncentracija holesterola i triglicerida. Kod `ena sa dislipi demijom i GDM postoji rizik od razvoja preeklam p si je. Veoma je va`no odre|ivati lipide u krvi `ena sa GDM u okviru prenatalne za{tite jer to poma`e ranom otkrivanju i le~enju PE. Summary: Gestational diabetes mellitus (GDM) is asso cia ted with increased risk of pregnancy-induced hypertension and other maternal and foetal complications of pregnancy. The aims of the study were to evaluate the serum lipid profile of women with GDM, and determine the number of women with GDM who have preeclampsia (PE). A retrospective study of 84 women with GDM and 90 pregnant women with nor mal glucose tolerance (controls) was condu cted. Women with GDM had significantly higher parity (p=0.047), total cholesterol (p=0.039) and triglycerides (p=0.033), but non-significantly lower HDL-cholesterol (p=0.086) when compared to controls. Systolic blood pressure was significantly elevated in women with GDM coupled with PE (GDM-PE; p=0.015), the mean birth weight of infants born to women with GDM-PE was significantly lower than that of women with only GDM (p=0.025). Women with GDM-PE had significantly higher triglycerides (p=0.020), had to be more multi-gravida (p=0.047) with significantly elevated VLDL-cholesterol (p=0.037) when compared with women with only GDM. 11.9% of women with GDM had PE. On the basis of these findings, it can be concluded that GDM is associated with hyperlipidaemia as evident by the significantly elevated total cholesterol and triglyceride concentrations. Women with dyslipidaemia and GDM are at risk of developing preeclampsia. It is imperative that blood lipids be evaluated in women with GDM during antenatal care as it would be helpful in the early detec tion and treatment of PE.

show abstract

“…They found increased plasma triglycerides and VLDL, but no difference in plasma cholesterol concentrations. 41 Zeynep Ersanli et al also found elevated Triglycerides in GDM group 10 . More recently Montelogo et al did not find any differences in serum lipid, lipoprotein or apolipoprotein concentrations in pregnant women with or without GDM 37 .…”

Section: Discussionmentioning

confidence: 99%

Offspring Birth Weight and Maternal Fasting Lipids in Women Screened for Gestational Diabetes Mellitus

Menon¹,

Nagarathna²,

Sudeep³

2018

MEDRECH

View full text Add to dashboard Cite

Introduction:The most common neonatal complication of gestational DM is macrosomia. During early pregnancy, an accumulation of maternal fat depots occurs followed by increased adipose tissue lipolysis and subsequent hyperlipidemia which mainly corresponds to increased triglycerides in all circulating lipoproteins. In GDM women the enhanced insulin resistance and altered estrogen-progesterone ratio are responsible for the reported wide range of dyslipidemic conditions 1 . Association of high maternal glucose levels and fetus macrosomia have been documented. The prospective Amsterdam Born children and development cohort study, reported that high maternal TG levels in early pregnancy were associated with higher Birth weights and subsequently a higher occurrence of LGA births, whereas low TG levels were associated with accelerated postnatal growth2. Total cholesterol, HDL and lipoprotein concentrations are not significantly different between GDM patients and control subjects3. Both maternal triglycerides and nonesterified fatty acids levels but not glucose in pregnancies with well-controlled gestational diabetes mellitus has been shown to correlate positively with both neonatal weight and fat mass4. Significantly elevated triglyceride levels in cord blood of obese GDM patients with macrosomic fetus suggests that TG may be important in the pathogenesis of fetal macrosomia5. We have undertaken this study to understand the relationship of hyperlipidemia in GDM pregnancy and the relationship between triglyceride levels and fetal macrosomia. Aims and Objectives: To correlate the relationship between fasting cholesterol and Triglycerides and offspring birthweight in women screened for GDM, To correlate the relationship between fasting maternal cholesterol, Triglycerides and mode of delivery and perinatal outcome.

show abstract

Relationships of Lipoprotein Lipids to Mild Fasting Hyperglycemia and Diabetes in Pregnancy

Cited by 55 publications

References 3 publications

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

Low prevalence of glucokinase gene mutations in gestational diabetic patients with good glycemic control

Lipid Profile and Clinical Characteristics of Women with Gestational Diabetes Mellitus and Preeclampsia

Offspring Birth Weight and Maternal Fasting Lipids in Women Screened for Gestational Diabetes Mellitus

Contact Info

Product

Resources

About