Relationships of human antroduodenal motility and transpyloric fluid movement: non-invasive observations with real-time ultrasound.

King, Paromita; Adam, R D; Pryde, Anne; McDicken, W.N.; Heading, R C

doi:10.1136/gut.25.12.1384

Cited by 119 publications

(73 citation statements)

References 26 publications

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“…To evaluate the gastric emptying time (GET), radiographic contrast studies [5,17], scintigraphy with radioisotopes [11,12], ultrasonography [2,4,14,22], radiopaque markers, such as bariumimpregnated polyspheres, CT and MRI scan, dye dilution method, measurement of blood concentration of interstinal absorbed drugs such as paraacetamol are some methods and others [9,10,12,16] have been used clinically in human beings and dogs. Each of these techniques has advantages and disadvantages compared each other, and there are few data which deal comparison of the ultrasound measurements with other methods for gastric emptying.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Canine Gastric Motility with Ultrasonography.

Choi

Seo

Jung

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. For the evaluation of canine gastric motility with ultrasonography, contraction number of pyloric antrum and gastric emptying time (GET) by area and volume method developed by Bolondi et al.'s method were studied in 14 dogs. All experimental dogs were administered with saline and soup solution (10 ml/kg, B.W.). The mean values of contraction number of pyloric antrum in saline and soup group were 4.19 ± 1.30/min and 4.82 ± 0.65/min before feeding, and overall mean values were 4.66 ± 1.37/min and 5.13 ± 1.71/ min, respectively. The mean values of the GET by area and volume method were 36.73 ± 11.27, 40.00 ± 8.87 min in saline group and 61.35 ± 17.58, 59.11 ± 14.46 min in soup group. In the GET in saline and soup groups, there was no significant difference between the area and volume method (p>0.05). Therefore, Bolondi et al.'s method by ultrasound can be used to evaluate the antropyloric motility and gastric emptying time with area and volume methods. The area method is easier to determine the GET than the volume method, but the latter is more accurate.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Canine Gastric Motility with Ultrasonography.

Choi

Seo

Jung

et al. 2002

The Journal of Veterinary Medical Science

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“…In 1984, King et al applied transabdominal two-dimensional (2D) ultrasonography in order to study (i) terminal antral contractions, (ii) duodenal contractions, (iii) forward flow movement of gastric content and (iv) retrograde flow movements through the pylorus (King et al, 1984). Seventeen healthy volunteers were given a test meal of 500 ml of water flavored with orange juice and warmed to 37°C, to which 0.5 g chopped and sieved bran was added.…”

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confidence: 99%

“…(c) An overview of all different organs that can be detected after ultrasonography. Adopted from King et al (1984). Copyright British Medical Journal 1984.…”

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confidence: 99%

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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(2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39960/1/FinalVersion-Revised-FOR_EPRINTS_1_YEAR_EMBARGO_ELSEVIER.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. After oral intake, a drug formulation is challenged by several gastrointestinal (GI) barriers. Complex variables such as pH, GI secretions and GI transit/motility along the GI tract can affect drug release and absorption in a positive or negative way depending on the physicochemical properties of the drug compound (e.g. pH/pKa interplay for ionizable drugs) and/or the formulation characteristics (e.g. pHsensitive coating). In addition, inter-subject variability in characteristics of the GI environment may cause variable drug absorption and systemic drug availability (Riethorst et al., 2015). Determining the median and range for specific GI variables, and understanding how they influence oral drug behavior along the GI tract, will be helpful in the field of drug development. 2The present review provides an overview of different methodologies that can be applied to study physiological variables of the human GI tract and their impact on oral drug absorption in healthy and patient populations. The methodologies have been subdivided into two groups: (i) noninvasive and (ii) invasive methodologies. Although some of the methodologies are more historical than operational, they have been of paramount importance for innovations in drug and formulation development; in addition, they have created the basis for several novel methodologies, leading to an in-depth comprehension of different GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and GI pH (intraluminal sampling and telemetry). Noninvasive methodologiesa. Scintigraphy Disturbances in the normal movement of food along the GI tract can be associated with abdominal pain, early satiety and nausea. Measurement of GI transit, es...

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“…The speed of ACWs and the ACW amplitude in the human stomach were calculated using data obtained by real-*To whom correspondence should be addressed. E-mail: Isao Kobayashi; isaok@affrc.go.jp Sosaku Ichikawa; sosaku.ichikawa.fn@u.tsukuba.ac.jp time MRI (King et al, 1984;Pallotta et al, 1998). The timedependent change of the viscosity of the gastric contents was measured using echo planar MRI (Marciani et al, 2000 and contract the flexible tubular walls in the simulated GI tract and control the pH, temperature, and the secretion of GI fluids (Minekus et al, 1995;Blanquet-Diot et al, 2004;Blanquet-Diot et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The speed of ACWs and the ACW amplitude in the human stomach were calculated using data obtained by real-*To whom correspondence should be addressed. time MRI (King et al, 1984;Pallotta et al, 1998). The timedependent change of the viscosity of the gastric contents was measured using echo planar MRI (Marciani et al, 2000).…”

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confidence: 99%

Development of a Human Gastric Digestion Simulator Equipped with Peristalsis Function for the Direct Observation and Analysis of the Food Digestion Process

Kozu

Nakata

Nakajima

et al. 2014

FSTR

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A novel in vitro gastric device, the Gastric Digestion Simulator (GDS), was developed for the direct observation and quantitative analysis of the food digestion process in the human stomach. In addition to simulating the chemical digestion environment, this device provides a physical digestion environment comparable to that found in the stomach by simulating peristalsis, which is assumed to contribute to solid food disintegration. The GDS was successfully used to directly observe the disintegration process of Tofu (bean curd) as a typical solid food containing protein. The size distribution and protein content of Tofu particles during the digestion experiments were investigated. The results demonstrated the difference in particle disintegration between GDS and flask shaking experiments, which may be due to the lack of peristalsis in the latter case. Moreover, the size distribution of Tofu particles after the GDS experiments was affected by the physical properties of Tofu, thus revealing the usefulness of GDS for food digestion analysis.Keywords: GI tract, gastric digestion, in vitro gastric device, peristalsis, direct observation, solid food IntroductionIn the human gastrointestinal (GI) tract, foods are digested by a combination of physical and chemical processes. Chemical digestive processes are catalyzed by digestive enzymes secreted in the stomach and small intestine, and disintegrate foods down to the molecular scale. However, physical digestive processes, which are induced mainly by peristalsis, mix and empty gastric and intestinal contents, and thus play an important role in promoting food digestion in the GI tract. Peristalsis in the GI tract is caused by peristaltic wall motion (e.g., antral contraction waves (ACWs)) in the stomach. Periodically generated ACWs induce the motion of the gastric contents, mix the gastric contents, and grind bulk solid foods to reduce their particle size (Kong and Singh, 2008) Food digestion in the human GI tract has been studied using in vivo, in vitro, and in silico approaches. MRI has been used for in vivo studies on gastric peristaltic motion and the physical properties of gastric contents. The speed of ACWs and the ACW amplitude in the human stomach were calculated using data obtained by real-*To whom correspondence should be addressed. time MRI (King et al., 1984;Pallotta et al., 1998). The timedependent change of the viscosity of the gastric contents was measured using echo planar MRI (Marciani et al., 2000). This study seeks to develop a new in vitro gastric digestion device that focuses mainly on the physical digestion environment of the human stomach, and to assess the device's performance. The gastric digestion simulator (GDS) that we developed here can simulate peristaltic motion in the human stomach and enables direct observation of the digestion process in real time. In this study, two different types of Tofu were used as model solid foods.We investigated food digestion characteristics using GDS to quantitatively understand the dynamic digestion processes in t...

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Relationships of human antroduodenal motility and transpyloric fluid movement: non-invasive observations with real-time ultrasound.

Cited by 119 publications

References 26 publications

Evaluation of Canine Gastric Motility with Ultrasonography.

Evaluation of Canine Gastric Motility with Ultrasonography.

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Development of a Human Gastric Digestion Simulator Equipped with Peristalsis Function for the Direct Observation and Analysis of the Food Digestion Process

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