Relationships of Enzymology to Cancer: A Review

Wr, Douglas

doi:10.1038/bjc.1963.58

Cited by 15 publications

(5 citation statements)

References 110 publications

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“…How ever, the later differ from the cancer tissue with regard to lactic acid produc tion. These observations are in accord with the wide report of similar findings in other varieties of human cancer tissue [9,26], Studies carried out on nor mal and tumor tissues in different species suggest particular 'profile' in cancer tissues [7], It is thought to prove of interest to screen the normal, cervicitis and malig nant cervix tissues obtained from human subjects for some of the enzymes of glycolytic pathway to see whether there is any change in enzyme pattern among these tissues. Since it was difficult to obtain cancer tissue, studies were restricted to the screening of the tissues for the following enzymes: hexokinase, glucose-6-phosphatase, phosphoglucomutase, glucose-6-phosphate de hydrogenase, glucose phosphate isomerase, hexose diphosphatase, fructosediphosphate aldolase, glyceraldehyde phosphate aldolase, glyceraldehyde phosphate dehydrogenase and lactate dehydrogenase.…”

Section: Introductionsupporting

confidence: 92%

Activities of Certain Enzymes of Glycolytic Pathway in Normal, Chronic Cervicitis and Malignant Human Cervix Uteri

Mainigi¹

1972

Oncology

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Studies on the activities of some glycolytic enzymes were carried out in normal, chronic cervicitis, and malignant human cervix uteri. In general, all the enzymes of glycolysis except glucose phosphate isomerase increases supporting the increased production of lactic acid. In chronic cervicitis tissue which also shows a higher rate of glucose utilization than normal tissue, but a lower rate of lactate production than cancer tissue, the increase in the activity of several enzymes is observed. However, compared to cancer, there is no change in glucose-6-phosphatase and aldolase activities.

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Section: Introductionsupporting

confidence: 92%

Activities of Certain Enzymes of Glycolytic Pathway in Normal, Chronic Cervicitis and Malignant Human Cervix Uteri

Mainigi¹

1972

Oncology

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“…All these facts, as does the incidence of prostatic cancer, coincide witi our finding that Eb stimulates the growth of experimental tumors. LDH is one of the enzymes that relates to glycolysis, and increase in the activity of this enzyme, according to Douglas (1963), is not a result of abnormal changes characteristic of malignancy itself but a result of its rapid growth and altered metabolism. Meister (1950) demonstrated an elevated LDH activity in experimental tumors, but we were unable to find out an appreciable increase in the LDH activity of the prostatic tissue following 20-MC administration, and this, as Hradec et al(1965) stated, appeares to be related more or less to interstitial hyperplasia, especially to aquamous metaplasia of the epithelium of the prostate following 20-MC administration.…”

Section: Methodsmentioning

confidence: 99%

Hormonal Effects on the Enzyme Activtties of the Prostate of Rat During 20-Methylcholanthrene Carcinogenesis

et al. 1968

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An attempt has been made to produce experimental cancer in the prostate of Wistar strain male rats by local administration of 20-methylcholanthrene (MC), thereby evaluating the incidence of neoplasmas, changes in activities of LDH and ALP, DNA metabolism and in the LDH isozymes pattern as well as the influence of sex hormones upon them. The following are the results obtained: 1) While estradiol benzoate (Eb) increased the incidence of prostatic neoplasmas, testosterone propionate (Tp) inhibited it. 2) DNA metabolism, especially the tritium index, was stimulated by Eb, whereas it was inhibited by Tp. 3) LDH activity was inhibited by Eb and promoted by Tp. As for the effects on the LDH isozymes pattern, Eb decreased the proportion of the M type, while Tp increased it. 4) ALP activity was somewhat suppressed by Eb administration.

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“…4) [18,19]. The histopathological changes of the liver tissue, the examinations of serum protein fractions, of certain groups of enzymes and isoenzymes in the serum and in the liver cell led to the conclusion that during the tumor growth an increasing insufficiency of the liver develops because of over strained liver functions or toxial lesion of the liver cells [4,12,13,16,22].…”

Section: Livermentioning

confidence: 99%

‘Systemic Effects’ during the Growth of Malignant Experimental Tumors

Ertl¹

1973

Oncology

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For an analysis of the effect of the tumor metabolites upon the organism of the tumor-bearing animal, correlation and kinetics of unspecific changes in some organs, such as thymus, adrenals, and liver, and the changes of body weight during the growth of the solid Walker carcino sarcoma 256 of the rat are described. The examination showed that the ‘systemic effects’ of the tumor in the various organs have a close physiological correlation with one another. Furthermore, the time of appearance and the kinetics of the organic changes are characteristic for the kind of tumor and the breed of animals. With regard to the progression of organ changes, the moment of beginning of thymus involution appeared to be of major importance. Therefore, it was used as point of reference when the temporal development of tumor growth was divided into a ‘compensated pre-involution stage’, with compensated metabolic balance; and into a ‘decompensated post-involution stage’, with decompensated metabolic balance. This classification might help to describe new results in tumor research with reference to known and uniformly defined factors inherent in the experiment and thus help to avoid contradictory experimental results or to find a common denominator for them. Possible consequences from an analysis of the kinetics of the ‘systemic effects’ for clinical cancer research and cancer treatment are suggested.

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Relationships of Enzymology to Cancer: A Review

Cited by 15 publications

References 110 publications

Activities of Certain Enzymes of Glycolytic Pathway in Normal, Chronic Cervicitis and Malignant Human Cervix Uteri

Activities of Certain Enzymes of Glycolytic Pathway in Normal, Chronic Cervicitis and Malignant Human Cervix Uteri

Hormonal Effects on the Enzyme Activtties of the Prostate of Rat During 20-Methylcholanthrene Carcinogenesis

‘Systemic Effects’ during the Growth of Malignant Experimental Tumors

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