Relationships of DTI findings with neurocognitive dysfunction in children with Type 1 diabetes mellitus

Toprak, Hüseyin; Yetiş, Hüseyin; Alkan, Alpay; Kurtcan, Serpil; Aralaşmak, Ayşe; Aksu, Mehmet Ş; Cesur, Yaşar

doi:10.1259/bjr.20150680

Cited by 17 publications

(20 citation statements)

References 35 publications

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“…Some recent studies showed lower AD and higher RD values in patients with hyperthyroidism, autoimmune diseases, and demyelinating diseases 9,10,23,24 . In our study, lower AD values of white matter pathways and basal ganglia may be associated with the disintegration of white matter tracts or axonal damage, despite its statistical insignificance after correction.…”

Section: Discussionsupporting

confidence: 44%

“…Decreased FA and increased MD values were presented in various neurodegenerative and neuropsychiatric disorders, such as autoimmune diseases, demyelinating disease, hypothyroidism, and diabetes mellitus 9–11,21,23,24 . It is well known that thyroid hormones regulate brain development.…”

Section: Discussionmentioning

confidence: 99%

“…AD measures the magnitude of diffusivity along the principal diffusion direction, while RD reflects the magnitude of diffusivity perpendicular to the principal diffusion direction 9 . FA values decrease in cases, such as white matter disintegration, axonal structural irregularity, and axonal degeneration 10 . Increased MD values lead to extracellular space enlargement due to local cellular damage or cerebral edema 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…FA values decrease in cases, such as white matter disintegration, axonal structural irregularity, and axonal degeneration 10 . Increased MD values lead to extracellular space enlargement due to local cellular damage or cerebral edema 10,11 . Additionally, an association between the decreased AD and axonal damage and increased RD and demyelination was reported 12,13 …”

Section: Introductionmentioning

confidence: 99%

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Brain Diffusion Tensor Imaging Findings in Hashimoto's Thyroiditis

Gültekin

Çeşme

Karaman

et al. 2020

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Hashimoto's thyroiditis (HT) is a type of autoimmune thyroid disease. Diffusion tensor imaging (DTI) can evaluate microstructural brain involvement in various diseases. We aimed to investigate whether there were any DTI differences in patients with HT, and the relationship between DTI values and disease duration time and thyroid peroxidase antibodies (TPOAb) levels. METHODS We prospectively included 36 patients with HT (mean age 41.6 ± 13.8 years, range 18‐64 years) and 18 age and sex‐matched healthy control subjects (mean age 41.6 ± 13.1 years, range 18‐63 years). All patients were euthyroid at the time of imaging. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values of 15 distinct neuroanatomical locations were measured and compared. RESULTS FA values of the patients with HT were lower in cingulum, globus pallidus (GP), cerebellar white matter (CWM) than the control (P = .019, .002, and <.001, respectively). MD values of the CWM in patients were higher than the control (P = .008). AD values of patients with HT were lower in the cingulum, posterior limbs of the internal capsule, GP, and putamen (P = .038, .038, .030, and .045, respectively). RD values of cingulum and CWM in HT were higher than controls (P <.001 and P = .011, respectively). There was a negative relationship between the FA values of PLIC and a positive relationship between the MD values of the corona radiata and TPOAb levels were detected. CONCLUSIONS The current DTI study presented microstructural changes in the neurocognitive‐related areas that may be related to accompanying neurological findings in HT.

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Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Diffusion Tensor Imaging Findings in Hashimoto's Thyroiditis

Gültekin

Çeşme

Karaman

et al. 2020

Journal of Neuroimaging

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“…Lower axial diffusivity in the temporal and parietal regions in children with T1DM also reported in a previous study (35). Another DTI study found a negative correlation between the ADC values of the parietal white matter, and indicate that brain damage may have begun at the cellular level in the preliminary stage of T1DM and neurocognitive impairments can't be avoided (36). Meanwhile, one DTI study found the fractional anisotropy was decreased in posterior white matter tracts, which have high connectivity with lots of posterior cortical regions, including the cuneus, precuneus, fusiform, and posterior parietal cortical regions (37).…”

Section: Discussionsupporting

confidence: 60%

Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus

et al. 2020

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Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted. Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics. Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations. Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.

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