Relationships between β-lactamase production and β-lactam susceptibility of environmental strains of Yersinia kristensenii

Ahmedy, Ali; Vidon, D; Labia, Roger; Delmas, Clément

doi:10.1016/0923-2508(89)90007-7

Cited by 2 publications

(2 citation statements)

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“…In the present study, aminopenicillin‐sensitive strains were only detected within the Y. kristensenii group. Bi‐ or polymodally distributed MICs of several β‐lactams were characteristic for this taxon (Table 3) and are in agreement with the broad MIC ranges published in the literature [42,45,46]. The heterogeneity of these MICs indicating strains expressing predominantly class A or class C β‐lactamases as well as low‐level enzyme producers may be a characteristic feature of all species of the Y. kristensenii complex or reflect its taxonomical heterogeneity [23].…”

Section: Discussionsupporting

confidence: 85%

“…The heterogeneity of these MICs indicating strains expressing predominantly class A or class C β‐lactamases as well as low‐level enzyme producers may be a characteristic feature of all species of the Y. kristensenii complex or reflect its taxonomical heterogeneity [23]. These suggestions are partly in contrast to the data of Ahmedy et al, who showed that each strain of Y. kristensenii expressed only one cephalosporinase belonging to one of three groups of β‐lactamases according to their p I s [45]. Class A β‐lactamases were not detected by Ahmedy et al and it was concluded that the lack of β‐lactamase class A accounts for the uniform carbenicillin sensitivity of the strains (MIC range 1–32 mg l −1 ).…”

Section: Discussionmentioning

confidence: 71%

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Natural antimicrobial susceptibilities and biochemical profiles ofYersinia enterocolitica-like strains:Y. frederiksenii,Y. intermedia,Y. kristenseniiandY. rohdei

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Wiedemann

2003

FEMS Immunology &Amp; Medical Microbiology

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The natural susceptibility of 131 Yersinia strains of Y. frederiksenii (n=38), Y. intermedia (n=48), Y. kristensenii (n=26) and Y. rohdei (n=19) to 70 antibiotics was tested. Minimum inhibitory concentration (MIC) values were determined with a microdilution procedure in IsoSensitest broth (all strains) and cation-adjusted Mueller Hinton broth (some strains). All species were naturally sensitive or sensitive and of intermediate susceptibility to tetracyclines, aminoglycosides, acylureidopenicillins, numerous cephalosporins, carbapenems, aztreonam, quinolones, chloramphenicol, folate-pathway inhibitors, nitrofurantoin, and fosfomycin. Uniform natural resistance was found with penicillin G, oxacillin, several macrolides, lincosamides, streptogramins, glycopeptides, rifampicin and fusidic acid. Species-specific differences in susceptibility affecting clinical assessment criteria were seen with aminopenicillins (in the presence and absence of beta-lactamase inhibitors), ticarcillin and some cephalosporins. Major medium-dependent susceptibilities were found with fosfomycin. beta-Lactam MIC susceptibility patterns suggested that most strains of the species tested produce both class A and class C (AmpC) beta-lactamases that are characteristic for the species. The present study describes a database concerning the natural susceptibility of some Y. enterocolitica-like species to a wide range of antibiotics, which can be applied to validate forthcoming antibiotic susceptibility tests of these strains and might contribute to their identification. An evaluation of 30 biochemical tests that secured phenotypic identification to the Yersinia species level is presented.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 71%