Relationships between Vitamin D3 and Metabolic Syndrome

Wieder-Huszla, Sylwia; Jurczak, Anna; Szkup, Małgorzata; Barczak, Katarzyna; Dołęgowska, Barbara; Schneider-Matyka, Daria; Owsianowska, Joanna; Grochans, Elżbieta

doi:10.3390/ijerph16020175

Cited by 25 publications

(18 citation statements)

References 56 publications

(72 reference statements)

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“…Interestingly, our study demonstrated that Vitamin D 3 deficiency <20ng/ml and BMI >35 were significant predictors for metabolic syndrome. This in agreement with a study of Wang and his colleagues that concluded that low Vitamin D 3 concentration is an independent risk factor for M.S [17,18].…”

Section: Discussionsupporting

confidence: 93%

Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population

Salama¹,

Mahros

2021

GMR

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Background: Metabolic syndrome (MS) has become a serious health problem worldwide and it is a major cause of morbidity and mortality especially from cardiovascular diseases. Different factors involved in pathogenesis like environmental, genetic, and sedentary life. Recent studies demonstrates that Vitamin D3 deficiency has a growing role in pathogenesis of MS. Many studies had addressed the relationship between serum Vitamin D3 and metabolic syndrome but to the best of our knowledge, few studies about this relationship in Egyptian population. Aims:To assess the relationship between deficiency of Vitamin D3 with metabolic syndrome in Egyptian population.Patients and methods: This is cross sectional study invite 200 participants from healthy clubs but only 180 accept to participate. According to the presence or absence of metabolic syndrome, our participant were divided into two groups. All participants were subjected to detailed medical history, clinical and anthropometric assessment, and laboratory analysis including serum Vitamin D3 level. Result:The mean age of the studied patients was 40.91±8.72, and majority were female (66.7%). Metabolic syndrome cases were significantly higher as regard the age, SBP, DBP, TG, FBS, WC and BMI but significantly lower regard HDL and Vitamin D3, and no significant association with sex. Vitamin D deficiency cases were significantly higher as regard Age, SBP, DBP, TG, FBS, WC and BMI but sig lower regard HDL. There was significant different between patients with and without Vitamin D3 deficiency as regard the presence of metabolic syndrome (P value=.00). There was moderate negative correlation between Vitamin D3 deficiency and age, SBP, DBP, FBS, WC and BMI with positive weak correlation with HDL level. Vitamin D3 deficiency < 20ng/ml and BMI >35 were significant predictors for metabolic syndrome with (P value 0.00, 0.04) respectively. Conclusion:Vitamin D3 level inversely correlates with the presence of metabolic syndrome in Egyptian

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Section: Discussionsupporting

confidence: 93%

Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population

Salama¹,

Mahros

2021

GMR

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“…We did not find association of vitamin D with MS. This is similar to the observation of Kwon and Lim in Korean population and Wieder-Huszla et al 2019 in women of Poland 12,14 . Vitamin D was not found as an independent predictor of fasting lipids in a British Bangladeshi adults 15 .…”

Section: Discussionsupporting

confidence: 92%

The Association of Vitamin D with Metabolic Syndrome in Adults with Prediabetes

Morshed¹,

Haq

Selim

et al. 2021

Bangla J Med

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Background: Vitamin D may play important role in the pathogenesis of several components of metabolic syndrome (MS). The aim of this study was to observe the association of vitamin D with MS and its components in Bangladeshi adults with prediabetes. Methods: This cross-sectional study was done among 117 newly detected nonpregnant adults with prediabetes [age (years): 36.30±9.99; BMI (kg/ m2): 28.89±4.35, mean±SD; M/F: 23/94] based on American Diabetes Association 2018 criteria. Metabolic syndrome was diagnosed by any three of five criteria: central obesity; elevated blood pressure, fasting blood glucose & triglyceride (TG) and lower HDL cholesterol. Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenase-peroxidase and vitamin D by high performance liquid chromatography method. Vitamin D <20 ng/ml was considered as deficiency (VDD). Results: Among all the variables only TG was significantly higher in patients with VDD than those without VDD (³20 ng/ml) [163.0 (135.50, 224.50) vs. 143.50 (101.25, 190.0), median (IQR), p=0.048]. There were no significant correlations [p=NS for all] and associations of vitamin D with MS or its components in linear and logistic regression [p=NS for all]. Conclusions: Except TG vitamin D has no associations with MS or its components in Bangladeshi adults with prediabetes. Bangladesh J Medicine July 2021; 32(2) : 170-174

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“…The binding of the active metabolite of vitD (1,25(OH) 2 D 3 or calcitriol) with its nuclear receptor, the VDR, which forms a heterodimeric complex with the retinoic acid receptor and interacts with transcript factors, results in the regulation of hundreds of different genes [ 32 , 33 ], increasing the intestinal and kidney absorption of calcium. A deficiency in vitD results in secondary hyperparathyroidism, causing increased osteoclast activity, osteopenia, and osteoporosis [ 34 ].…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

Innao

Allegra

Ginaldi

et al. 2021

IJMS

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Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bone marrow. In patients affected by multiple myeloma, vitamin D deficiency is commonly correlated with an advanced stage of the disease, greater risk of progression, the development of pathological fractures, and a worse prognosis. Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. However, in spite of the findings available in the literature, there is no clear standard of care and clinical practice varies. Further research is needed to better understand how vitamin D influences outcomes in patients with monoclonal gammopathies.

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Relationships between Vitamin D3 and Metabolic Syndrome

Cited by 25 publications

References 56 publications

Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population

Does Vitamin D Deficiency Correlates with Metabolic Syndrome in Egyptian Population

The Association of Vitamin D with Metabolic Syndrome in Adults with Prediabetes

Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies

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