Relationships between Total, Free and Bioavailable Vitamin D and Vitamin D Binding Protein in Early Pregnancy with Neonatal Outcomes: A Retrospective Cohort Study

Fernando, Melinda; Coster, Thisara G.; Ellery, Stacey J.; Guingand, Deborah De; Lim, Siew; Harrison, Cheryce L.; Teede, Helena; Naderpoor, Negar; Mousa, Aya

doi:10.3390/nu12092495

Cited by 7 publications

(11 citation statements)

References 59 publications

(71 reference statements)

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“…Even after covariates adjustment, the risk of SGA increased by 9% for each one unit decrease of maternal plasma 25(OH)D concentration [ 54 ]. Similarly, a retrospective Australian study of 304 pregnancies showed that increased maternal total and free 25(OH)D levels were associated with higher neonatal birthweight, when data are adjusted for maternal age, BMI, and ethnicity [ 55 ]. Another Australian prospective cohort study including 402 women concluded that maternal serum 25(OH)D levels at recruitment (<16 weeks) in smokers were inversely related with offspring fat mass percentage, but positively related with neonatal lean mass.…”

Section: Resultsmentioning

confidence: 99%

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

Dimas

Politi

Bargiota

et al. 2022

IJMS

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Fetal exposure in adverse environmental factors during intrauterine life can lead to various biological adjustments, affecting not only in utero development of the conceptus, but also its later metabolic and endocrine wellbeing. During human gestation, maternal bone turnover increases, as reflected by molecules involved in bone metabolism, such as vitamin D, osteocalcin, sclerostin, sRANKL, and osteoprotegerin; however, recent studies support their emerging role in endocrine functions and glucose homeostasis regulation. Herein, we sought to systematically review current knowledge on the effects of aforementioned maternal bone biomarkers during pregnancy on fetal intrauterine growth and metabolism, neonatal anthropometric measures at birth, as well as on future endocrine and metabolic wellbeing of the offspring. A growing body of literature converges on the view that maternal bone turnover is likely implicated in fetal growth, and at least to some extent, in neonatal and childhood body composition and metabolic wellbeing. Maternal sclerostin and sRANKL are positively linked with fetal abdominal circumference and subcutaneous fat deposition, contributing to greater birthweights. Vitamin D deficiency correlates with lower birthweights, while research is still needed on intrauterine fetal metabolism, as well as on vitamin D dosing supplementation during pregnancy, to diminish the risks of low birthweight or SGA neonates in high-risk populations.

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Section: Resultsmentioning

confidence: 99%

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

Dimas

Politi

Bargiota

et al. 2022

IJMS

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“…Vitamin D Binding Protein (VDBP) genotype, which is associated with variations in vitamin D status (68), has been recently associated with the occurrence of premature membrane rupture and pregnancy loss as well gestational diabetes and neonatal outcomes such as birth weight (69)(70)(71).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D-binding protein genotype, which is associated with variations in vitamin D status, 68 has been recently associated with the occurrence of premature membrane rupture and pregnancy loss as well gestational diabetes and neonatal outcomes such as birth weight. [69][70][71] Additionally, studies looking into the relationship between iPTH and free 25(OH)D concentrations are also warranted. This study, as well as other similar studies, have only explored the relationship between iPTH and total 25(OH)D, not looking into the possible impact of free 25 (OH)D. Further research is still needed in this area.…”

Section: Discussionmentioning

confidence: 99%

Post Hoc Analysis of National Institute of Child Health and Human Development Vitamin-D Pregnancy Cohort and The Role of Functional Vitamin-D Deficiency in Pregnancy

Davis,

Lyles,

Shary

et al. 2023

Am J Perinatol

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Objective: Conduct a secondary, post-hoc analysis of NICHD vitamin D (vitD) pregnancy study by Hollis et al. (Hollis, 2011), which reported on the effect of vitD supplementation in pregnant women; and determine the potential interaction between intact parathyroid hormone (iPTH) concentrations, vitD status, and various comorbidities associated with pregnancy. Hypothesis: Women with low 25(OH)D concentrations and high iPTH concentrations during pregnancy, known as functional vitD deficiency (FVDD), were more likely to acquire complications also affecting their neonates. Study Design: This post-hoc analysis of data collected from a diverse group of pregnant women participating in the NICHD vitD pregnancy study, was applied to investigate the applicability of the concept of FVDD in pregnancy (Hemmingway, 2018) in identifying potential risks for certain comorbidities of pregnancy. This analysis defines FVDD as maternal serum 25(OH)D concentrations below 20 ng/mL and iPTH concentrations above 65 pg/mL creating a definitive ratio number, 0.308, to classify mothers as having FVDD prior to delivery (PTD). Statistical analyses were performed using SAS 9.4 (Cary, NC). Results: 281 women (85 African American, 115 Hispanic, 81 Caucasian) with 25(OH)D and iPTH concentrations measured at monthly visits were included in this analysis. No statistically significant association was found between mothers classified as having FVDD at baseline or one-month PTD and hypertensive disorders of pregnancy, infection, or admittance to the NICU. When combining all comorbidities of pregnancy in this cohort, results showed those with FVDD at baseline, 24 weeks’ gestation, and one-month PTD were more likely to experience a comorbidity (p=0.001; p=0.001; p=0.004, respectively). Those with FVDD one-month PTD were 7.1 times (CI 1.71-29.81) more likely to have preterm birth (<37 weeks) than women without FVDD. Conclusions: Participants were more likely to have experienced preterm birth if they met the criteria for FVDD. This study supports the importance of FVDD during pregnancy.

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“…Successful implantation is a result of complex molecular interactions between the hormonally primed uterus and mature blastocyst, which is necessary for pregnancy continuity ( Ochoa-Bernal and Fazleabas, 2020 ). Some studies have linked vitamin D (VD) status with pregnancy loss and neonatal outcomes ( Mumford et al, 2018 ; Fernando et al, 2020 ). However, the precise physiological function of VD during pregnancy is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

et al. 2021

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Synchronized uterine receptivity with the time of implantation is crucial for pregnancy continuity. Vitamin D (VD) deficiency has been linked to the failure of implantation. Therefore, we tested the link between the Homeobox transcription factor-10/immunophilin FK506-binding protein 52 (HOXA-10/FKBP52) axis and the uterine receptivity in VD-deficient rats. The effect of VD supplementation at different doses was also investigated. Forty-eight pregnant rats were divided into six groups (eight/group); normal control rats fed with standard chow (control), control rats supplemented with VD (equivalent dose of 400 IU/day) (control-D400). VD-deficient group (DEF) and the three VD deficiency groups with VD supplementation were equivalent to 400, 4,000, and 10,000 IU/day (DEF-D400, DEF-D4000, and DEF-D10000, respectively). The expression levels of HOXA-10/FKBP52, progesterone level, and histological evaluation of decidualization using osteopontin (OSN) and progesterone receptor (PGR) were estimated. An assessment of the uterine contractility was conducted for all rats. This study showed the downregulation of HOXA-10/FKBP52 together with increased amplitude and frequency of the uterine contractility in the DEF group compared to control. VD dose-dependent supplementation restored progesterone/receptor competency, upregulated the expressional response of HOXA-10 and its downstream FKBP52, and improved uterine receptivity and endometrial decidualization at the time of implantation that was documented by increased area% of OSN and the number of implantation beads.

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Relationships between Total, Free and Bioavailable Vitamin D and Vitamin D Binding Protein in Early Pregnancy with Neonatal Outcomes: A Retrospective Cohort Study

Cited by 7 publications

References 59 publications

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review

Post Hoc Analysis of National Institute of Child Health and Human Development Vitamin-D Pregnancy Cohort and The Role of Functional Vitamin-D Deficiency in Pregnancy

Vitamin D Supplementation Improves Uterine Receptivity in a Rat Model of Vitamin D Deficiency: A Possible Role of HOXA-10/FKBP52 Axis

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