Relationships between tissue concentrations of polycyclic aromatic hydrocarbons and antioxidative responses of marine mussels, Perna viridis

Cheung, C. C. C.; Zheng, Gene J.; Li, A.M.Y; Richardson, Bruce J.; Lam, Paul K.S.

doi:10.1016/s0166-445x(00)00145-4

Cited by 376 publications

(137 citation statements)

References 51 publications

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“…38 On the other hand, additional studies have pointed out that a decreased enzyme activity in response to oxidative stress may accompany an initial exposure to xenobiotic, which can be followed by an induction of the antioxidant system. 39 In the present study, IAA treatment resulted in a significant decrease in gene expression of the antioxidant enzymes.…”

Section: Discussionsupporting

confidence: 50%

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Mourão

Cruz

Paulo

et al. 2008

Cell Biochemistry & Function

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In this study, we report the protective effects of IAA on diethylnitrosamine (DEN)-induced hepatocarcinogenesis. BALB/c mice received daily IAA at 50 (T 50 ), 250 (T 250 ), and 500 (T 500 ) mg Kg À1 per body mass by gavage for 15 days. At day 15, animals were administered DEN and sacrificed 4 h later. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed in sera. In addition, hepatomorphologic alterations, activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), gene expression of antioxidant enzymes and DNA integrity were evaluated in the liver. IAA administration did not show any alterations in any of the parameters available, except for a reduction of the gene expression for antioxidant enzymes by 55, 56, 27, and 28% for SOD, CAT, GPx, and GR upon T 500 , respectively compared with the control. Several hepatic alterations were observed by DEN exposure. Moreover, IAA administration at 3 doses was shown to provide a total prevention of the active reduction of CAT and GR induced by DEN exposure compared with the control. IAA at T 500 was shown to give partial protection (87, 71, 57, and 90% for respectively SOD, CAT, GPx, and GR) on the down-regulation of the enzymes induced by DEN and this auxin showed a partial protection (50%) on DEN-induced DNA fragmentation for both parameters when compared to DEN alone. This work showed IAA hepatocarcinogenesis protection for the first time by means of a DEN-protective effect on CAT and GR activity, and by affecting antioxidant gene expression and DNA fragmentation.

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Section: Discussionsupporting

confidence: 50%

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Mourão

Cruz

Paulo

et al. 2008

Cell Biochemistry & Function

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“…The use of mussel transplant experiments has been critical in the examination of effects from petroleum contamination in coastal environments (Widdows et al, 1981;Cheung et al, 2001;Honkoop et al, 2003;Peteiro et al, 2006 …”

Section: Introductionmentioning

confidence: 99%

Effect of field exposure to 38-year-old residual petroleum hydrocarbons on growth, condition index, and filtration rate of the ribbed mussel, Geukensia demissa

Culbertson

Valiela

Olsen

et al. 2008

Environmental Pollution

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In September 1969, the Florida barge spilled 700,000 L of No. 2 fuel oil into the salt marsh sediments of Wild Harbor, MA. Today a substantial amount, approximately 100 kg, of moderately degraded petroleum remains within the sediment and along eroding creek banks. The ribbed mussels, Geukensia demissa, which inhabit the salt 2 marsh creek bank, are exposed to the spilled oil. Examination of short-term exposure was done with transplantation of G. demissa from a control site, Great Sippewissett marsh, into Wild Harbor. We examined the effects of long-term exposure with transplantation of mussels from Wild Harbor into Great Sippewissett. Both the short-and long-term exposure transplants exhibited slower growth rates, shorter mean shell lengths, lower condition indices, and decreased filtration rates. Our results add new knowledge about long-term consequences of spilled oil, a dimension that should be included when assessing oil-impacted areas and developing management plans designed to restore, rehabilitate, or replace impacted areas. Capsule Ribbed mussels exposed to residual petroleum in salt marsh sediments, in short-term and long-term transplant experiments, exhibited significant effects that should be considered when assessing oil-impacted areas and developing management plans.

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“…But recently, it has been demonstrated in vivo and in vitro that low doses of PAH could increase defence mechanisms against oxidative stress as well as to promote its own detoxification. Cheung, Zheng, Li, Richardson, & Lam (2001) in a local mussel (Perna viridis), observed an increase in gill GSH levels and a high activity of gill GPx after exposure at sites polluted with PAHs. The GSH levels and the GPx activity were strongly correlated with tissue benzo(a)pyrene and total PAHs' levels.…”

Section: Discussionmentioning

confidence: 94%

The mechanism of the antioxidant effect of smoked paprika from La Vera, Spain

Tormo

Campillo

Viña

et al. 2013

CyTA - Journal of Food

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This study aimed at further investigating the antioxidant effect of smoked paprika (Pimento´n La Vera, Spain) in healthy subjects. Crossover study included male students (age 20.6 + 1.7 years) who consumed smoked or non-smoked paprika (2 g/day, 20 times, over 30 days). After ingestion of smoked paprika, plasma malondialdehyde (MDA) levels were significantly (p 5 0.01) reduced versus basal and non-smoked paprika ingestion values. Reduced glutathione (GSH) levels were increased and oxidised glutathione (GSSG) levels reduced significantly (p 5 0.05) in paired subjects after consumption of smoked paprika. Smoked paprika significantly increased mRNA levels of glutathione peroxidase and cytochrome c oxydase versus non-smoked paprika ingestion. The low dose of polycyclic aromatic hydrocarbons (PAHs) contained in the smoked paprika could cause an activation of antioxidant defences as increasing activity of the GSH cycle and activating some antioxidant enzyme such as glutathione peroxidase and cytochrome c oxidase.Keywords: smoked paprika; reduced and oxidised glutathione; glutathione peroxidase; cytochrome c oxydase Este estudio investiga el efecto antioxidante del pimento´n ahumado (Pimento´n La Vera, Espan˜a) en sujetos sanos. Estudiantes varones (edad 20,6 + 1,7 an˜os) consumieron pimento´n ahumado o no ahumado (2 g/dı´a, 20 veces, durante 30 dı´as). Tras la ingestio´n del pimento´n ahumado los niveles plasma´ticos de malondialdehido (MDA) se redujeron (p 5 0,01) frente a los valores basales y a los obtenidos tras la ingestio´n de pimento´n no ahumado. Los niveles de glutatio´n reducido (GSH) aumentaron y los de glutatio´n oxidado (GSSG) disminuyeron (p 5 0,05) tras la ingestio´n de pimento´n ahumado. La ingestio´n de pimento´n ahumado incremento´significativamente los niveles de mRNA de glutatio´n peroxidasa y citocromo c oxidasa. Las pequen˜as dosis de hidrocarburos policı´clicos aroma´ticos (PHAs) contenidas en el pimento´n ahumado activarı´an las defensas antioxidantes al aumentar la actividad de sistemas antioxidantes como el ciclo GSH y la sı´ntesis de enzimas como glutatio´n peroxidasa y citocromo c oxidasa.

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Relationships between tissue concentrations of polycyclic aromatic hydrocarbons and antioxidative responses of marine mussels, Perna viridis

Cited by 376 publications

References 51 publications

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Protective action of indole‐3‐acetic acid on induced hepatocarcinoma in mice

Effect of field exposure to 38-year-old residual petroleum hydrocarbons on growth, condition index, and filtration rate of the ribbed mussel, Geukensia demissa

The mechanism of the antioxidant effect of smoked paprika from La Vera, Spain

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