Relationships Between Rectal Wall Dose–Volume Constraints and Radiobiologic Indices of Toxicity for Patients With Prostate Cancer

Marzi, Simona; Arcangeli, Giorgio; Saracino, Bianca; Petrongari, Maria Grazia; Bruzzaniti, Vicente; Iaccarino, Giuseppe; Landoni, V.; Soriani, A.; Benassi, Marcello

doi:10.1016/j.ijrobp.2006.12.003

Cited by 36 publications

(27 citation statements)

References 22 publications

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“…Analogous findings were reported by Peeters et al who demonstrated a stronger correlation between high-dose exposure to high-dose radiation and gastrointestinal toxicity [40]. The same conclusion was reported by Marzi et al [36]. No association was found between rectal toxicity and the volume exposed to intermediate doses, as reported by other authors [11,24].…”

Section: Resultssupporting

confidence: 84%

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

et al. 2009

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Section: Resultssupporting

confidence: 84%

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

et al. 2009

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“…From Gamma distributions, in addition, we found that the number of patients with a dose V ones. This finding well agrees with our toxicity data (zero) and with literature which reports that late rectal toxicity is mostly related to the size of the high dose region [10]- [17] [30]- [34].…”

Section: Discussionsupporting

confidence: 94%

Construction of a Simple Rectum Model Using Image Guidance in Prostate Patients Treated with 3D Conformal Radiotherapy

D’Andrea¹,

Falco²,

Fedele³

et al. 2014

JCT

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Purpose: To evaluate the performance of a rectum model in predicting late rectal toxicity of prostate patients undergoing 3D conformal radiation therapy while following a dietary protocol combined with image guidance. Methods: A linear accelerator equipped with a Cone Beam Computed Tomography (CBCT) system was used to treat 20 patients who were following a dietary protocol. The set-up was verified by co-registering CBCT scans with the planning CT scan (pCT). A mean dose volume histogram () as the arithmetical mean of the rectum DVHs from each CBCT scan was obtained. A suitably defined 3D rectum model (Average Rectum, AR) was defined and its DVH (DVHAR) was calculated. DVHs were also evaluated for the first five CBCT scans using both methods ( and DVHAR5). The Lyman-Kutcher-Burman NTCP model with QUANTEC parameters was used to compare the calculated DVHs. The QUANTEC dose values were used to describe the time behaviour of the relative volumes using the Gamma Distribution for the frequency of the relative rectum volumes at each QUANTEC dose value. Results: No statistically significant differences between NTCPAR5 and NTCPAR and between NTCP and NTCP were found. The best agreement with the observed toxicity rate (0%) was obtained form DVHAR. The Gamma Distributions of the rectum volumes at the QUANTEC dose levels were found to be highly variable among the patients. Conclusions: Both dietary protocol and image guidance were found effective in limiting late rectal toxicity. AR was a better predictor for late rectal toxicity and better described the * Corresponding author. M. D'Andrea et al. 1040rectum volume during the treatment course. Finally, from the Gamma distributions, and from our toxicity data, we can suggest V75 as the best predictor of late rectal toxicity.

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“…We constructed hypothetical treatment plans as if we were delivering IMRT alone to a total dose of 8,100 cGy in 45 daily fractions over a period of 9 weeks. We then determined rectal wall volumes that would have received 6,000 cGy (V60) and 7,000 cGy (V70) relative to the total rectal wall volume (23,24). These values are known as the rectal wall relative V60 and V70.…”

Section: Radiotherapy Planning and Treatmentmentioning

confidence: 99%

Cross-Linked Hyaluronan Gel Reduces the Acute Rectal Toxicity of Radiotherapy for Prostate Cancer

Wilder

Barme

Gilbert

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Relationships Between Rectal Wall Dose–Volume Constraints and Radiobiologic Indices of Toxicity for Patients With Prostate Cancer

Cited by 36 publications

References 22 publications

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

Evaluation of late rectal toxicity after conformal radiotherapy for prostate cancer

Construction of a Simple Rectum Model Using Image Guidance in Prostate Patients Treated with 3D Conformal Radiotherapy

Cross-Linked Hyaluronan Gel Reduces the Acute Rectal Toxicity of Radiotherapy for Prostate Cancer

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