Relationships between pregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern

Rashidi, Batool; Sadeghi, Maryam; Jafarabadi, Mina; Nejad, Ensiyeh Shahrokh Tehrani

doi:10.1016/j.ejogrb.2004.08.016

Cited by 85 publications

(84 citation statements)

References 31 publications

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“…Other studies suggest that an endometrial thickness of 10 mm or greater at the time of transfer achieves the best results [10,15]. Although we did not demonstrate any difference in endometrial thickness between patients who became pregnant and those who did not, the average endometrial thickness at the time of embryo transfer was close to 10 mm in women who underwent the natural cycle protocol.…”

Section: Discussioncontrasting

confidence: 54%

Natural cycle cryo-thaw transfer may improve pregnancy outcome

Morozov

Ruman

Kenigsberg

et al. 2007

J Assist Reprod Genet

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Objective: To compare natural vs. hormone replacement treatment (HRT) for cryo-thaw embryo transfer cycles in patients with frozen embryos from previous ART. Design and Settings: Retrospective chart review of 164 patients (242 cycles) who underwent natural or HRT cryo-thaw embryo transfer between January 2002 and April 2005. Main Outcome Measures: Pregnancy rates per transfer in natural and HRT cryo-thaw cycles. Results: The pregnancy rate per transfer was higher with natural cycles (36.76% vs. 22.99%, P = 0.0298). There was no statistical difference in mean age, endometrial thickness, and average embryo quality in successful cycles. Mean endometrial thickness prior to transfer was greater in natural cycles (9.95 vs. 8.89 mm, P < 0.001). Mean serum estradiol levels were higher in the HRT group prior to transfer (526.1 vs. 103.8 pg/ml, P < 0.001), and were found to be lower in women who achieved pregnancy (337.1 vs. 433.3 pg/ml, P = 0.0136). Conclusion: Hormone replacement in preparation for cryo-thaw transfer of embryos was found to be associated with decreased pregnancy rates in comparison to natural cycle cryo-thaw transfer. Greater endometrial thickness was achieved with lower serum estradiol levels in patients undergoing natural cycles, suggesting Financial disclosure: none of the above authors had any financial interests with commercial companies.

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Section: Discussioncontrasting

confidence: 54%

Natural cycle cryo-thaw transfer may improve pregnancy outcome

Morozov

Ruman

Kenigsberg

et al. 2007

J Assist Reprod Genet

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“…A number of studies have indicated a higher pregnancy rate at a partic- ular endometrial thickness (29)(30)(31)(32)(33), while alternative studies indicated no significant correlation between endometrial thickness and pregnancy rates in IVF/ICSI patients (34)(35)(36)(37)(38)(39). The present study indicated that clinical pregnancy rates following embryo transfer are positively correlated with endometrial thickness, which is consistent with previous studies (39)(40)(41).…”

Section: Discussionsupporting

confidence: 82%

“…A number of studies have evaluated the association between endometrial thickness and pregnancy rates in patients undergoing assisted reproductive technology; however, the results remain controversial (29)(30)(31)(32)(33)(34)(35)(36)(37)(38). A number of studies have indicated a higher pregnancy rate at a partic- ular endometrial thickness (29)(30)(31)(32)(33), while alternative studies indicated no significant correlation between endometrial thickness and pregnancy rates in IVF/ICSI patients (34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Yin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the association between follicular fluid (FF) levels of high-mobility group box 1 (HMGB1) protein and the reproductive outcome in patients undergoing in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). FF samples were collected from the ovarian follicles (≥14 mm) of 143 infertile patients that had undergone IVF/ICSI, and the HMGB1 expression levels were determined using ELISA. Spearman's correlation and receiver operating characteristic (ROC) curve analysis were applied to analyze the results. Significantly increased levels of HMGB1 protein (7.38±2.02 vs. 6.14±2.52 ng/ml; P<0.01), endometrial thickness on the day of human chorionic gonadotropin (hCG) administration (10.3±1.3 vs. 9.7±1.7 mm; P<0.01) and retrieved oocyte counts (11.68±6.51 vs. 11.00±6.34; P<0.01) were observed in the pregnant group when compared with the non-pregnant group. Conversely, the level of luteinizing hormone on the day of hCG administration was significantly reduced in the pregnant group compared with the non-pregnant group (0.92±1.78 vs. 1.78±2.03 pmol/l, P<0.01). The ROC curve indicated a significant association between the FF level of HMGB1 protein and the pregnancy rate, with an area under the ROC curve of 0.673 (0.581-0.765; P<0.01). In addition, the HMGB1 protein level was shown to have a significant positive correlation with the endometrial thickness (r=0.170; P<0.05). Therefore, the present study indicated that the FF levels of HMGB1 protein are increased in pregnant patients and are positively correlated with endometrial thickness. Thus, FF levels of HMGB1 may be a useful factor for predicting the outcome of IVF/ICSI treatments.

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“…It is generally accepted that a thin endometrial stripe on transvaginal ultrasound is associated with a reduced embryo implantation potential [5,9,10], while others have reported an adverse effect of an increased endometrial thickness [2]. The echogenic pattern of the endometrium has also been suggested to be a predictor of pregnancy outcome [8,25].…”

Section: Discussionmentioning

confidence: 99%

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

Barker

Boehnlein

Kovács

et al. 2009

J Assist Reprod Genet

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Purpose To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Methods Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist downregulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.Results Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes. Conclusions Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.

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Relationships between pregnancy rates following in vitro fertilization or intracytoplasmic sperm injection and endometrial thickness and pattern

Cited by 85 publications

References 31 publications

Natural cycle cryo-thaw transfer may improve pregnancy outcome

Natural cycle cryo-thaw transfer may improve pregnancy outcome

Association between follicular fluid levels of HMGB1 protein and outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection cycles

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles

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