Relationships between plasma neurofilament light chain protein, cognition, and brain aging in people with HIV
Sarah A. Cooley,
Kalen J. Petersen,
Caitlin Tice
et al.
Abstract:Objective:
Neurofilament light chain protein (NfL) is a marker of neuronal injury and neurodegeneration. Typically assessed in cerebrospinal fluid, recent advances have allowed this biomarker to be more easily measured in plasma. This study assesses plasma NfL in people with HIV (PWH) compared to people without HIV (PWoH), and its relationship with cognitive impairment, cardiovascular risk, and a neuroimaging metric of brain aging (brain-age gap).
Design:
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