Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system

Castagné, Vincent; Gautschi, Matthias; Lefèvre, Karine; Posada, Andrés; Clarke, Peter G. H.

doi:10.1016/s0301-0082(99)00012-x

Cited by 127 publications

(62 citation statements)

References 415 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Generation of reactive oxygen species is currently viewed as one of the process through which epileptic activity exert their deleterious effects on brain 22 . These reactive oxygen species in the absence of an efficient cellular defence mechanism cause peroxidation of membrane poly unsaturated fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Santos

Campêlo

Freitas³

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes. The present research suggests that antioxidant compounds may afford some level of neuroprotection against the neurotoxicity of seizures in cellular level. The objective of the present study was to evaluate the lipoic acid (LA) effects in glutamate and taurine contents in rat hippocampus after pilocarpine-induced seizures. Wistar rats were treated intraperitoneally (i.p.) with 0.9% saline (Control), pilocarpine (400 mg/kg, Pilocarpine), LA (10 mg/kg, LA), and the association of LA (10 mg/kg) plus pilocarpine (400 mg/kg), that was injected 30 min before of administration of LA (LA plus pilocarpine). Animals were observed during 24 h. The amino acid concentrations were measured using high-performance liquid chromatograph (HPLC). In pilocarpine group, it was observed a significant increase in glutamate content (37%) and a decrease in taurine level (18%) in rat hippocampus, when compared to control group. Antioxidant pretreatment significantly reduced the glutamate level (28%) and augmented taurine content (32%) in rat hippocampus, when compared to pilocarpine group. Our findings strongly support amino acid changes in hippocampus during seizures induced by pilocarpine, and suggest that glutamate-induced brain damage plays a crucial role in pathogenic consequences of seizures, and imply that strong protective effect could be achieved using lipoic acid through the release or decrease in metabolization rate of taurine amino acid during seizures. Key words: seizures, pilocarpine, amino acids, hippocampus, glutamate, taurine.Efeitos do ácido lipóico nas concentrações de glutamato e taurina no hipocampo de ratos após convulsões induzidas por pilocarpina RESUMO As convulsões induzidas pela pilocarpina podem ser mediadas através do aumento do estresse oxidativo cerebral e das alterações na concentração dos aminoácidos. O presente estudo sugere que compostos antioxidantes podem produzir neuroproteção contra a neurotoxicidade em nível celular causada pelas convulsões. O objetivo deste estudo foi avaliar os efeitos do ácido lipóico (AL) no conteúdo de glutamato e taurina no hipocampo de ratos durante convulsões induzidas por pilocarpina. Ratos Wistar foram tratados por via intraperitoneal com solução salina 0,9% (controle), pilocarpina (400 mg/kg, pilocarpina), AL (10 mg/kg) e com a associação de AL (10 mg/kg); 30 min após com pilocarpina (400 mg/kg), que foi injetada 30 min após a administração de AL (AL + pilocarpina). Os animais foram observados durante 24 horas. As concentrações de aminoácidos foram

show abstract

Section: Discussionmentioning

confidence: 99%

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Santos

Campêlo

Freitas³

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…18. The main reason why attention to these different forms of cell death may be clinically important is that several of the distinct forms of cell demise are controlled by distinct molecular mechanisms (20)(21)(22)(23). Another widespread misconception relating to the mode of cell death is the belief that only necrosis elicits inflammation.…”

Section: Cell Demise In Neurodegenerationmentioning

confidence: 99%

Series Introduction: Neurodegeneration: What is it and where are we?

Przedborski¹,

Vila²,

2003

View full text Add to dashboard Cite

“…Oxidative stress in brain is particularly vulnerable occurrence as a consequence of increased intracellular levels of reactive oxygen species, possibly due to its high consumption of oxygen during oxidative phosphorylation (Castagne et al, 1999) forms a common pathway leading to neuronal death (Ames et al, 1993) and the processes can become disturbed as reported for aging (Beckman and Ames, 1998) and several neurological disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) (Dringen, 2000).…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Insulin on Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells

Mahesh¹,

Kim²

2009

Biomolecules and Therapeutics

View full text Add to dashboard Cite

-Insulin appears to play a role in brain physiology, and disturbances of cerebral insulin signalling and glucose homeostasis are implicated in brain pathology. The objective of the present study was to investigate the protective effects of insulin under conditions of oxidative stress induced by hydrogen peroxide (H2O2) in C6 glial cells. Insulin at concentration of 10 −7 M could prevent 12 h H2O2-induced cell death. The formation of reactive oxygen species (ROS), nitric oxide (NO) and 2-thiobarbituric acid-reactive substances (TBARS) were significantly scavenged by insulin pre-treatment in C6 glial cells after H 2 O 2 -induced oxidative stress. Insulin significantly stimulated the phosphorylation of Akt in the cells and the activation of Akt was maintained in response to insulin under H2O2 incubation for 12 h. In conclusion, these results provide evidence that insulin acts as a free radical scavenger and stimulating Akt activity. These data suggest that insulin may be effective in degenerative diseases with oxidative stress.

show abstract

Relationships between neuronal death and the cellular redox status. Focus on the developing nervous system

Cited by 127 publications

References 415 publications

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Series Introduction: Neurodegeneration: What is it and where are we?

The Protective Effects of Insulin on Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells

Contact Info

Product

Resources

About