Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients

Mulè, Giuseppe; Riccobene, Raffaella; Castiglia, Antonella; D’Ignoto, Francesco; Ajello, Elena; Geraci, Giulio; Guarino, L; Nardi, Emilio; Vaccaro, Francesco; Cerasola, Giovanni; Cottone, Santina

doi:10.1016/j.numecd.2014.01.014

Cited by 32 publications

(19 citation statements)

References 28 publications

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“…The positive relationship between SUA and PWV is in contrast with our previous report based on a smaller population sample, where SUA showed no independent significant association with PWV [34]. However, this new finding of ours is in agreement with various reports from the literature, where a strong association has been found between SUA and PWV [35][36][37][38]. A moderate association between BMI and AIx has already been described, that is again in agreement with our findings [41].…”

Section: Discussionsupporting

confidence: 91%

Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study

et al. 2015

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The correlation of both obstructive sleep apnoea syndrome (OSAS) and snoring with cardiovascular risk is well known, but its investigation is complex and not suitable for studying large cohorts of subjects. Thus, we prospectively evaluated 1476 non-pharmacologically treated subjects selected from the last survey of the Brisighella Heart Study. Snoring and sleep apnoea were investigated asking the subjects if they were aware of snoring during the night, and if this was associated with episodes of apnoea. A full set of clinical and laboratory parameters were evaluated, while augmentation index (AIx), and pulse wave velocity (PWV) were recorded with the Vicorder(®) apparatus. A logistic regression analysis identifies as main independent predictors of AIx age (OR 1.058, 95% CI 1.043-1.065, p < 0.001), Body Mass Index (OR 1.046, 95% CI 1.014-1.079, p = 0.005), and apolipoprotein B (OR 1.014, 95% CI 1.004-1.023, p = 0.001). The main independent predictors of PWV are snoring (OR 1.215, 95% CI 1.083-1.390, p < 0.001), and snoring with apnoea (OR 1.351, 95% CI 1.135-1.598, p = 0.014), age (OR 1.078, 95% CI 1.052-1.089, p < 0.001), serum uric acid [SUA] (OR 1.093, 95% CI 1.026-1.151, p < 0.001) and mean arterial pressure (OR 1.042, 95% CI 1.024-1.056, p < 0.001). In conclusion, in our cohort of overall healthy subjects, self-reported snoring and sleep apnoea are independently associated with a higher PVW, and AIx is statistically significantly higher in snorers with or without sleep apnoea than in non-snorers. Body Mass Index and apolipoprotein B are associated with AIx, while SUA and mean arterial pressure are related to PWV.

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Section: Discussionsupporting

confidence: 91%

Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study

et al. 2015

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“…Endocrine and renovascular hypertension were ruled out, as previously described . Persons who reported smoking cigarettes regularly during the past year were considered current smokers.…”

Section: Methodsmentioning

confidence: 99%

“…If the patient agreed, in case of poor‐quality recordings, ABPM was repeated within 1 week of the first evaluation. Further details regarding the procedures for ABPM were published previously …”

Section: Methodsmentioning

confidence: 99%

Relationship Between Short‐Term Blood Pressure Variability and Subclinical Renal Damage in Essential Hypertensive Patients

Mulè

Calcaterra

Costanzo

et al. 2015

J of Clinical Hypertension

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The authors aimed to analyze the relationship between subclinical renal damage, defined as the presence of microalbuminuria or an estimated glomerular filtration rate (eGFR) between 30 mL/min/1.73 m 2 and 60 mL/min/ 1.73 m 2 and short-term blood pressure (BP) variability, assessed as average real variability (ARV), weighted standard deviation (SD) of 24-hour BP, and SD of daytime and nighttime BP. A total of 328 hypertensive patients underwent 24-hour ambulatory BP monitoring, 24-hour albumin excretion rate determination, and eGFR calculation using the Chronic Kidney Disease Epidemiology Collaboration equation. ARV of 24-hour systolic BP (SBP) was significantly higher in patients with subclinical renal damage (P=.001). This association held (P=.04) after adjustment for potential confounders. In patients with microalbuminuria, ARV of 24-hour SBP, weighted SD of 24-hour SBP, and SD of daytime SBP were also independently and inversely related to eGFR. These results seem to suggest that in essential hypertension, short-term BP variability is independently associated with early renal abnormalities. J Clin Hypertens (Greenwich). 2015;17:473-480. ª 2015 Wiley Periodicals, Inc.Since the pioneering observations of Stephen Hales during the 18th century it has been recognized that blood pressure (BP) is not a constant parameter; rather, it shows marked spontaneous oscillations over shortterm (minutes to hours) and long-term (days to months) periods. Far from being a "background noise" that hindered assessment of "true BP," short-term BP variability (BPV) seems to be relevant to the pathophysiology of target organ damage and to the incidence of clinical events, as suggested by studies performed in humans by invasive continuous 24-hour BP measurements 1,2 and as clearly shown by investigations conducted in sinoaortic-denervated rats.3-6 Although the precise quantification of short-term BPV requires beatto-beat BP recording, 7 its assessment is also possible, even if less accurately, through the use of intermittent noninvasive 24-hour ambulatory BP monitoring (ABPM). However, studies in which short-term BPV was estimated by ABPM yielded conflicting results. 8-32Short-term BP variability has been usually estimated by 24-hour, daytime, or nighttime standard deviation (SD) of average BP. However, the limitations of the SD as a measure of short-term BPV have stimulated the search of more refined BPV estimates. 6,7,10,13,20,21 One of these is the average real variability (ARV) of 24-hour BP, ie, the average of the absolute differences of consecutive measurements. 20 This statistical parameter is sensitive to the individual BP measurement order and less sensitive to low sampling frequency of ABPM. 21Some studies suggest that ARV better predicts cardiovascular (CV) risk in comparison to the traditional SD. 20,22,23 Another new index of short-term BPV is the "weighted" SD of the 24-hour mean value, ie, the average SD of daytime and nighttime BP, each weighted for the duration of the day and night periods, respectively. This in order ...

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“…Previous studies have reported that the association of uric acid level with arterial stiffness remains controversial (Chen et al, 2010;Lim et al, 2010;Tsioufis et al, 2011;Fang et al, 2014;Saijo et al, 2005;Bae et al, 2013;Mulè et al, 2014).…”

Section: Measuring Pulse Wave Velocity (Pwv) Is a Noninvasivementioning

confidence: 99%

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

Sull

Koh

Cho

et al. 2017

BSL

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Measuring the pulse wave velocity (PWV) is a non-invasive method for evaluating the stiffness of the vessel wall. While previous studies investigated the association of uric acid level with arterial stiffness, most did not consider smoking status and obesity as covariates. The objective of this study was to investigate the relationship between uric acid levels and arterial stiffness, considering smoking status and obesity. We studied 3390 subjects (1940 males and 1450 females). Abnormal PWV was also defined as the highest quartile of values in the subjects. Data were analyzed using Pearson correlation, t-test, and multiple regression analysis. Approximately 41.9% of men and 3.7% of women were current smokers. Prevalence of hypertension was 11.4% in men and 7.0% in women. In women, hyperuricemia was associated with abnormal PWV (OR 1.58; 95% CI 1.03~2.43). Hyperuricemia was also associated with abnormal PWV (OR 2.37; 95% CI 1.01~5.59) in non-or light male smokers with normal blood pressure. This study suggests that uric acid is associated with arterial stiffness in women and non-smoking men.

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Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients

Cited by 32 publications

References 28 publications

Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study

Association between self-reported snoring and arterial stiffness: data from the Brisighella Heart Study

Relationship Between Short‐Term Blood Pressure Variability and Subclinical Renal Damage in Essential Hypertensive Patients

Association of Uric Acid Levels with Arterial Stiffness in Korean Women and Non-smoking Men

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