Relationships between Maternal Ethnicity, Gestational Age, Birth Weight, Weight Gain, and Severe Retinopathy of Prematurity

Husain, Shahid; Sinha, Ajay; Bunce, Catey; Arora, Puneet; López, Wilson López; Mun, Kwok Sean; Reddy, M. Ashwin; Adams, Gillian

doi:10.1016/j.jpeds.2012.12.038

Cited by 60 publications

(48 citation statements)

References 32 publications

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“…[18][19][20][21][22][23][24][25][26][27][28][29] Interestingly, there is increasing evidence that ethnicity may be an independent risk factor for the development of severe ROP. [30][31][32][33] However, no North American studies on IGF-1 and ROP have been reported to our knowledge.…”

mentioning

confidence: 95%

Postnatal serum insulin-like growth factor i and retinopathy of prematurity

Jensen

Ying

Huang³

et al. 2015

Journal of American Association for Pediatric Ophthalmology and

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mentioning

confidence: 95%

Postnatal serum insulin-like growth factor i and retinopathy of prematurity

Jensen

Ying

Huang³

et al. 2015

Journal of American Association for Pediatric Ophthalmology and

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“…The limited published studies show conflicting results on how race/ethnicity may affect mortality of preterm infants [9,10]. Studies on how race/ethnicity affects different morbidities in preterm infants are even scarcer, and mostly focus on extremely premature infants [11,12]. …”

Section: Introductionmentioning

confidence: 99%

Racial and Ethnic Disparities in Preterm Infant Mortality and Severe Morbidity: A Population-Based Study

et al. 2017

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Background: Disparities exist in the rates of preterm birth and infant mortality across different racial/ethnic groups. However, only a few studies have examined the impact of race/ethnicity on the outcomes of premature infants. Objective: To report the rates of mortality and severe neonatal morbidity among multiple gestational age (GA) groups stratified by race/ethnicity. Methods: A retrospective cohort study utilizing linked birth certificate, hospital discharge, readmission, and death records up to 1 year of life. Live-born infants ≤36 weeks born in the period 2007-2012 were included. Maternal self-identified race/ethnicity, as recorded on the birth certificate, was used. ICD-9 diagnostic and procedure codes captured neonatal morbidities (intraventricular hemorrhage, retinopathy of prematurity, periventricular leukomalacia, bronchopulmonary dysplasia, and necrotizing enterocolitis). Multiple logistic regression was performed to evaluate the impact of race/ethnicity on mortality and morbidity, adjusting for GA, birth weight, sex, and multiple gestation. Results: Our cohort totaled 245,242 preterm infants; 26% were white, 46% Hispanic, 8% black, and 12% Asian. At 22-25 weeks, black infants were less likely to die than white infants (odds ratio [OR] 0.76; 95% confidence interval [CI] 0.62-0.94). However, black infants born at 32-34 weeks (OR 1.64; 95% CI 1.15-2.32) or 35-36 weeks (OR 1.57; 95% CI 1.00-2.24) were more likely to die. Hispanic infants born at 35-36 weeks were less likely to die than white infants (OR 0.66; 95% CI 0.50-0.87). Racial disparities at different GAs were also detected for severe morbidities. Conclusions: The impact of race/ethnicity on mortality and severe morbidity varied across GA categories in preterm infants. Disparities persisted even after adjusting for important potential confounders.

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“…In a study conducted by Husain et al (17), weight gain as well as birth weight and gestational age was found significantly lower in the early stage in patients who had treatment-requiring ROP. They also showed that being of black race was protective against ROP (16).…”

Section: Discussionmentioning

confidence: 89%

“…Weight gain after delivery in preterm babies is affected by many factors including disease severity, feeding intolerance, frequency of septic events, and prolonged mechanical respiratory support. Insufficient intake of protein and energy under these conditions inhibits normal retinal vascularization (17). In addition, babies with malnourishment have low serum IGF-1 levels and this increases the risk in terms of the development of ROP by disrupting VEGF signalization (8).…”

Section: Discussionmentioning

confidence: 99%

The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity

Dorum¹,

Yılmaz²,

Köksal³

et al. 2017

Turk Pediatri Ars

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Aim: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide. Material and Methods: We prospectively studied newborn infants born at a postmenstrual age of <32 weeks and birth weights <1 500 gr, between Results: Among the 40 infants, 11 (27.5%) constituted the retinopathy of prematurity group and 29 comprised the non-retinopathy of prematurity group. In the retinopathy of prematurity group, the mean gestational age and birth weight was significantly lower. The demographic features of the study cohort were similar. The duration of mechanical ventilation was significantly greater in the retinopathy of prematurity group compared with the non-retinopathy of prematurity group (p=0.036). In terms of neonatal morbidities such as respiratory distress syndrome, intraventricular hemorrhage, bronchopulmonary dysplasia, patent ductus arteriosus, and necrotizing enterocolitis, no differences were detected between the groups. The mean serum insulin-like growth factor-1 levels in retinopathy of prematurity group were significantly lower than those in the non-retinopathy of prematurity group at each time point ( Conclusions: This study demonstrated the low serum insulin-like growth factor-1 levels was associated with retinopathy of prematurity development. (Turk Pediatri Ars 2017; 52: 10-4)

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Relationships between Maternal Ethnicity, Gestational Age, Birth Weight, Weight Gain, and Severe Retinopathy of Prematurity

Cited by 60 publications

References 32 publications

Postnatal serum insulin-like growth factor i and retinopathy of prematurity

Postnatal serum insulin-like growth factor i and retinopathy of prematurity

Racial and Ethnic Disparities in Preterm Infant Mortality and Severe Morbidity: A Population-Based Study

The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity

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