Relationships between magnesium and protein concentrations in serum.

Kroll, Martin H.; Elin, R J

doi:10.1093/clinchem/31.2.244

Cited by 135 publications

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“…8,9,10 The remainder is found in bones and soft tissues, the latter of which is primarily skeletal muscle and liver. 9 Magnesium in serum occurs in 3 forms: a protein-bound, nonultrafilterable form (approximately 25-30%) and 2 ultrafilterable forms, the chelated and ionized forms, which together account for approximately 70-75% of serum Mg. [13][14][15] The chelated form is complexed with phosphate, citrate, and other compounds and constitutes a small percentage of ultrafilterable Mg. 7,15 The ionized form is believed to be the physiologically active component. 7,10 In the past, most diagnostic laboratories have measured only total serum Mg concentrations.…”

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confidence: 99%

Validation of the Nova CRT8 for the measurement of ionized magnesium in feline serum

Gilroy

Burton

Horney

et al. 2005

Veterinary Clinical Pathol

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confidence: 99%

Validation of the Nova CRT8 for the measurement of ionized magnesium in feline serum

Gilroy

Burton

Horney

et al. 2005

Veterinary Clinical Pathol

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“…The ratio of UfMg to total Mg increases progressively during development (1 5): it is about 56% in preterm neonates, 62% in term neonates and 66% in infants; it only reaches the adult value of 70% after the first year of life. Plasma Mg bounds preferently to albumin but no significant correlations were present between the plasma concentration of Mg and that of albumin or total protein, findings already recognized in adults (16). The increased protein binding in neonates and young infants is apparently paradoxical as the plasma albumin is usually lower in these age groups.…”

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confidence: 70%

Renal magnesium handling in infants and children

1996

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Renal handling of magnesium (Mg) has been incompletely studied during infancy and childhood due to the difficulty, until recently, of measuring the diffusible fraction of plasma Mg. In the present investigation this methodology has been used to assess Mg homeostasis in 45 healthy infants, aged 1 to 12 months, and in 63 healthy children, aged 1 to 15 years. When compared to children, infants had significantly higher plasma values (mean +/- SD) for both total (0.76 +/- 0.08 versus 0.70 +/- 0.06 mmol l-1; p < 0.001) and ultrafilterable Mg (0.51 +/- 0.07 versus 0.49 +/- 0.04 mmol l-1; p < 0.05). No significant correlations were present between values of plasma Mg and plasma concentrations of calcium, creatinine, total protein or albumin. The ratio Umg/Ucr, calculated in the second morning urine (median, 3rd-97th centiles), was also significantly higher during infancy (0.023, 0.009-0.07 versus 0.015, 0.006-0.04; p < 0.001). On the contrary, fractional excretion of Mg (median, 3rd-97th centiles) was identical in both age groups and did not correlate significantly with age (infants: 3.2, 1.0-7.8%, children 3.4, 1.6-8.1%; p = NS). During a Mg infusion, carried out in six children, we could establish an approximative value for renal Mg threshold (plasma ultrafilterable Mg = 0.50 mmol l-1) close to that found in adults. These results indicate that no functional immaturity is present during infancy for renal tubular reabsorption of Mg and that the high Umg/Ucr ratio observed in this age group is a phenomenon not dependent on a higher urinary Mg excretion but probably related to a lower urinary creatinine excretion per unit of lean body mass.

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“…Total sMg concentration corrected for albumin was according to Krolles proposed formula: corrected sMg (mmol/L) = measured total sMg (mmol/ L)10.005 (40 À (sAlb (g/L))). 19 All measurements were performed at the GHRC laboratory of Shiraz Medical University.…”

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confidence: 99%

Is there an association between intradialytic hypotension and serum magnesium changes?

Pakfetrat¹,

Roozbeh²,

Malekmakan³

et al. 2010

Hemodialysis International

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Intradialytic hypotension (IDH) is the most common complication of hemodialysis (HD). The aim of this study was to investigate the significance of intradialytic changes of serum magnesium (sMg) and its relation to IDH. We considered 58 patients undergoing HD. Serum magnesium was measured at start, after 2 hours, and at the end of the HD sessions. Total sMg concentration corrected for albumin was according to Krolles proposed formula. Blood pressure was measured every 30 min. Data were analyzed by SPSS.15. A P value of less than 0.05 was considered as significant. Occurrence of IDH among HD patients was 27.6% (16/58). Serum magnesium decreased significantly during HD session (P<0.05). Comparing corrected sMg in IDH group with non-IDH group showed that: corrected sMg was 0.66 ± 0.14 mmol/L vs. 0.84 ± 0.26 mmol/L at the start of dialysis (P=0.43), 0.62 ± 0.17 mmol/L vs. 0.74 ± 0.23 mmol/L (P=0.04) at 2 hours, and 0.61 ± 0.12 mmol/L vs. 0.72 ± 0.22 mmol/L (P=0.03) at the end of dialysis. Intradialytic hypotension episodes were significantly related to a decrease in sMg during dialysis (P=0.02). There was a significant decrease in sMg levels during dialysis. Intradialytic hypotension was significantly related to lowered sMg levels during dialysis.

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Relationships between magnesium and protein concentrations in serum.

Cited by 135 publications

References 0 publications

Validation of the Nova CRT8 for the measurement of ionized magnesium in feline serum

Validation of the Nova CRT8 for the measurement of ionized magnesium in feline serum

Renal magnesium handling in infants and children

Is there an association between intradialytic hypotension and serum magnesium changes?

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