Abstract:Based on data analysis and interpretation, rough set theory provided data relationships that were objective and interpretable. The method is simple, general, and efficient, and lays the foundation for further applications in other cities.
“…Lung cancer is the leading cause of cancer‐related morbidity and mortality worldwide, and remains a serious public health concern . Developing countries observe higher rates of incidence because of polluted air . Although great advances in surgical, radiotherapy, and chemotherapy approaches have been made during the last two decades, the disease is still a major concern.…”
Section: Introductionmentioning
confidence: 99%
“…11 Developing countries observe higher rates of incidence because of polluted air. 12 Although great advances in surgical, radiotherapy, and chemotherapy approaches have been made during the last two decades, the disease is still a major concern. The five-year survival rate of non-small cell lung cancer (NSCLC), the most prevalent type, is about 15%.…”
BackgroundEugenol, a natural compound available in Syzigium aromaticum (cloves), is exploited for various medicinal applications. Eugenol induces apoptosis and functions as an anti‐cancer drug in several types of tumors. We investigated the tumor suppressive role and potential mechanisms of eugenol in human lung cancer cells.MethodsHuman embryonic lung fibroblast MRC‐5 and lung cancer adenocarcinoma A549 cells were incubated with or without various concentrations of eugenol for 24 hours. Cell counting kit 8 and crystal violet staining assays were performed to detect cell viability. The cell migration and invasion abilities were also determined by wound healing and transwell assays. Finally, Western blotting assay was performed to examine the changes in lung cancer cell viability and invasion of downstream targets after treatment with eugenol.ResultsEugenol could inhibit cell viability in lung cancer cells. Furthermore, eugenol obviously impaired cell migration and invasion. Finally, the expression levels of phosphate‐Akt and MMP‐2 in lung cancer cells were reduced after treatment with eugenol.ConclusionOur results demonstrated the tumor suppressive roles of eugenol on lung cancer cell proliferation, migration, and invasion partially through the PI3K/Akt pathway and MMP activity in vitro. These results suggest eugenol as a potential chemotherapeutic agent against human lung cancer.
“…Lung cancer is the leading cause of cancer‐related morbidity and mortality worldwide, and remains a serious public health concern . Developing countries observe higher rates of incidence because of polluted air . Although great advances in surgical, radiotherapy, and chemotherapy approaches have been made during the last two decades, the disease is still a major concern.…”
Section: Introductionmentioning
confidence: 99%
“…11 Developing countries observe higher rates of incidence because of polluted air. 12 Although great advances in surgical, radiotherapy, and chemotherapy approaches have been made during the last two decades, the disease is still a major concern. The five-year survival rate of non-small cell lung cancer (NSCLC), the most prevalent type, is about 15%.…”
BackgroundEugenol, a natural compound available in Syzigium aromaticum (cloves), is exploited for various medicinal applications. Eugenol induces apoptosis and functions as an anti‐cancer drug in several types of tumors. We investigated the tumor suppressive role and potential mechanisms of eugenol in human lung cancer cells.MethodsHuman embryonic lung fibroblast MRC‐5 and lung cancer adenocarcinoma A549 cells were incubated with or without various concentrations of eugenol for 24 hours. Cell counting kit 8 and crystal violet staining assays were performed to detect cell viability. The cell migration and invasion abilities were also determined by wound healing and transwell assays. Finally, Western blotting assay was performed to examine the changes in lung cancer cell viability and invasion of downstream targets after treatment with eugenol.ResultsEugenol could inhibit cell viability in lung cancer cells. Furthermore, eugenol obviously impaired cell migration and invasion. Finally, the expression levels of phosphate‐Akt and MMP‐2 in lung cancer cells were reduced after treatment with eugenol.ConclusionOur results demonstrated the tumor suppressive roles of eugenol on lung cancer cell proliferation, migration, and invasion partially through the PI3K/Akt pathway and MMP activity in vitro. These results suggest eugenol as a potential chemotherapeutic agent against human lung cancer.
“…The relationship between cases of nonspecific conjunctivitis and air pollutants (CO, NO2, SO2, and O3) by CFA symbolic scatter plots is illustrated in Figure 3. The predictive model plots nonspecific conjunctivitis incidence (cases) versus air pollutants (CO, NO2, SO2, and O3) in Equation (1). Table 7 demonstrates that air pollutants are associated with nonspecific conjunctivitis cases, and the regression model plots the nonspecific conjunctivitis incidence (cases) versus CO, NO2, SO2, and O3 in Equation (16).…”
Section: The Relationship Between Air Pollutants and The Case Of Nonsmentioning
confidence: 99%
“…Air pollutions are correlated with many adverse health effects and diseases, and this is well recognized by many studies (1)(2)(3)(4)(5). WHO describes air pollution as "the contamination of the indoor or outdoor environment by any chemical, physical or biological agent that modifies the natural characteristics of the atmosphere (6)."…”
Section: Introductionmentioning
confidence: 99%
“…Findings from most of the previous studies showed that air pollutants have negative influence on health. Studies on lung cancer (1,2), acute respiratory infection (3), liver cancer (4), and menstrual cycle (5) showed a significant correlation between health and air pollutants. Dense innervations in the ocular surface are extremely sensitive to environmental agents (7).…”
Background: As a directly exposed part of the human body, the eyes are susceptible to external stimulations of air pollution. The ill effects of air pollution on human eyes are mostly irritation and inflammation, with conjunctivitis being a significant problem. Method: This study investigates the impact of air pollution on nonspecific conjunctivitis based on the data from ophthalmologic outpatient visits. The research focuses on the significance of air pollution's impact on ocular health. Data for ophthalmology outpatient visits were obtained from the National Health Insurance Research Database of Taiwan. Ambient air monitoring data were obtained from the Taiwan Environmental Protection Administration air pollution monitoring stations. Six regulated air pollutants were included in the studies. This study used symbolic data analysis to investigate the association between daily air pollutant concentrations and the number of outpatient visits for nonspecific conjunctivitis as well as the relationship between climate factors and air pollutants. Results: O3 (t-value=2.292, p-value=0.025) is positively correlated with nonspecific conjunctivitis cases; this result is the same as plot (d) in Figure 3. The relationship between nonspecific conjunctivitis cases and CO (t-value=-1.183, p-value=0.240) / NO2 (t-value=0.653, p-value=0.516) / NO2 (t-value=0.653, p-value=0.516) / SO2 (t-value=-0.942, p-value=0.349) is not statistically significant. Conclusion: The result of this study shows that the air pollutant, O3 is significantly related to nonspecific conjunctivitis. The air pollutant, O3 can increase chances of outpatient visits, suggesting that is a possible cause for nonspecific conjunctivitis.
BackgroundAmbient ne particulate matter (PM 2.5 ) is one of the main environmental air pollutants that closely related to the development of lung cancer, but the mechanisms are unclear.
ResultsIn this study, A549 cells were exposed to ambient PM 2.5 to investigate the alterations of biological behaviors, and the possible role of miR-582-3p in the effects was further explored. The ndings showed that that PM 2.5 exposure could signi cantly enhance the biological behaviors of A549 cells, and promote their EMT transformation, especially at relatively low doses. Over-activation of Wnt/β-catenin signaling pathway and increased expression of miR-582-3p were also found in A549 cells after PM 2.5 exposure.After the knockdown of miR-582-3p in A549 cells, the effects of PM 2.5 on malignant biological behavior changes, EMT and the activation of Wnt/β-catenin signaling pathway were all signi cantly alleviated. Furthermore, the inhibition of Wnt/β-catenin signaling pathway also inhibited the EMT process of A549 cells, which was rescued by the overexpression of miR-582-3p.
ConclusionThis study showed that ambient PM 2.5 can up-regulate the expression of miR-582-3p, consequently activate the Wnt/β-catenin signaling pathway, thereby enhance EMT transformation and promote the malignant biological behaviors of A549 cells. These ndings provide evidence for further research into the mechanisms by which exposure to PM 2.5 in the environment promotes lung cancer.
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