Relationships between in Vitro Toxicity, Tissue Effects and Mineralogical Composition of Coal Mine Dusts

Bouffant, L. Le; Degueldre, G.; Bruch, Joachim; Rosmanith, J; Reisner, M. T. R.; Bruyet, B.; Daniel, H.; Demarez, J.; Kovacs, M. P.; Martin, Jean-Charles; Addison, J. R.; Bolton, Robert; Davis, J. Michael; Dodgson, J S; Gormley, I. P.; Hadden, G. G.; Robertson, Alastair H.F.

doi:10.1007/978-3-642-70630-1_54

Cited by 2 publications

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“…Comparison of different techniques employed in four European laboratories to gauge toxicity failed to establish a correlation between dust composition, in vitro results, and epidemiology, while in vivo procedures fared only a little better, the lymph node reaction seeming to carry promise (114). The problem of predicting risk from in vitro methods is compounded by the remarkably higher resistance to the toxic effects of coal mine dust and quartz exhibited by human macrophages as compared with those of rodents (115).…”

Section: Cellular Responsesmentioning

confidence: 99%

Prevalence and Pathogenesis of Pneumoconiosis in Coal Workers

Heppleston¹

1988

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.Dust dose and composition do not appear to account wholly for changes in the prevalence of coal workers' pneumoconiosis in Europe. In certain coal pits high progression evidently occurred with relatively low dust exposure or vice versa, whereas progression in relation to dust levels might be variable. Exceptionally high quarts concentrations occur in coal mine dust when pneumoconiosis may progress with unusual rapidity. Under such circumstances lesions resembling silicotic nodules may be found, but with the customarily lower levels of quart the pathological features assume the form characteristic of coal workers. Morphological changes in relation to dust content of human and animal lungs, as well as cellular behavior, have not accounted completely for the epidemiological findings. Considering all the pathological evidence helps explain the pathogenesis of pneumoconiosis and vagaries of progression. The origin of progressive massive fibrosis cannot be explained simply in terms of dust burden or immunological features, and the role of an infective factor cannot be dismissed. Moreover, lipid secretion by alveolar epithelium introduces a new element that could affect the development of simple and complicated pneumoconiosis. In vitro, cytotoxicity appeared to be too variable for predictive purposes, though direct assay of fibrogenicity using the macrophage fibrogenic factor suggested that dust dose was more important than dust composition. Assessing individual susceptibility presents serious obstacles.

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Section: Cellular Responsesmentioning

confidence: 99%