Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients

Maccario, Mauro; Ramunni, J.; Oleandri, S. E.; Procopio, Massimo; Grottoli, Silvia; Rossetto, Ruth; Savio, P; Aimaretti, Gianluca; Camanni, F.; Ghigo, Ezio

doi:10.1038/sj.ijo.0800889

Cited by 78 publications

(61 citation statements)

References 34 publications

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“…Nevertheless, significant inverse associations between IGF-I levels and BMI have been reported in earlier studies (35)(36)(37). By contrast, investigations have also shown significant positive associations between IGF-I levels and BMI in Japanese and Chinese men (15,38).…”

Section: Discussionmentioning

confidence: 62%

Association between Insulin-Like Growth Factor-I

Sandhu

Gibson

Heald

et al. 2004

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Several prospective observational studies have suggested that elevated circulating IGF-I levels are associated with an increased risk of cancer. These observations may provide a potential mechanism through which previously identified metabolic and anthropometric factors, such as obesity and elevated insulin and glucose levels, may operate. We therefore examined metabolic and anthropometric influences on circulating levels of insulinlike growth factor-I (IGF-I), insulin-like growth factorbinding protein-1 (IGFBP-1), and the IGF-I:IGFBP-1 ratio in a middle-aged population of 349 men and 492 women. IGF-I showed only modest inverse associations with indices of adiposity. However, we found that low IGFBP-I levels and an increased IGF-I:IGFBP-1 ratio were strongly associated with increased levels of insulin and glucose in men and women. Body mass index was also positively related to the IGF-I:IGFBP-1 ratio in men (P < 0.001) and women (P < 0.001), independent of metabolic correlates of IGFBP-1 and IGF-I. Similarly, waist:hip ratio and waist circumference were also associated with an increased IGF-I:IGFBP-1 ratio and low circulating IGFBP-1 levels. These findings suggest that individuals with greater fat mass and upper body obesity may have elevated levels of bioavailable or free IGF-I, which could, in part, mediate the reported associations among metabolic and anthropometric factors and cancer risk.

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Section: Discussionmentioning

confidence: 62%

Association between Insulin-Like Growth Factor-I

Sandhu

Gibson

Heald

et al. 2004

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…We are in agreement with others (4,34,38) who have concluded that type 2 diabetes and the hyperinsulinemic state typically associated with obesity and insulin resistance in these patients could cause low bone mass (independent of body size) and that this relationship is possibly mediated by deficiency in insulin-like growth factors. Studies have found low (43), normal (44,45), and high (46) IGF-I levels in obese subjects. Whether or not overweight children with IGT have abnormal IGF-I levels should be investigated in longitudinal studies of this population.…”

Section: Discussionmentioning

confidence: 99%

Impaired Glucose Tolerance and Bone Mineral Content in Overweight Latino Children With a Family History of Type 2 Diabetes

2005

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OBJECTIVE -Research on the skeletal status of pre-diabetic (type 2 diabetic) children is warranted. We examined the hypothesis that bone mineral content (BMC) and bone mineral density (BMD) will be lower in children with impaired glucose tolerance (IGT) versus normal glucose tolerance (NGT).RESEARCH DESIGN AND METHODS -Total body BMC and BMD of 184 overweight Latino children (106 boys, 78 girls, 11.9 Ϯ 1.7 years) with a family history of type 2 diabetes were measured using dual-energy X-ray absorptiometry. Glucose tolerance was assessed by 2-h glucose after an oral glucose tolerance test. Area under the insulin curve (AUC) assessed the cumulative insulin response to oral glucose. Acute insulin response to glucose (AIR) was determined by an intravenous glucose tolerance test.RESULTS -Partial correlations revealed an inverse relationship between BMC and AIR (r ϭ Ϫ0.29, P ϭ 0.00), AUC (r ϭ Ϫ0.28, P ϭ 0.00), fasting insulin (r ϭ Ϫ0.16, P ϭ 0.04), and 2-h insulin (r ϭ Ϫ0.16, P ϭ 0.04). There was no significant difference in BMC or BMD between children with IGT (n ϭ 46) or NGT (n ϭ 138). Stepwise multiple linear regression revealed that 89% of the variance in BMC is attributed to lean mass (87%), age (1%), and AIR (1%). BMD was explained by lean mass (69%), Tanner stage (3%), and AUC (2%).CONCLUSIONS -The findings of this study suggest that in overweight children, lean mass is the primary predictor of BMC and BMD, whereas age, Tanner stage, and the acute and cumulative insulin responses to oral glucose make subtle independent contributions to the total variances. In addition, poor glycemic control does not seem to be detrimental to bone mass of pre-diabetic children.

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“…For example, IGF-I concentrations in obese subjects are negatively and independently associated with body mass index (BMI) as well as age. 16 Furthermore, it has been shown that the elevated leptin in overnutrition, probably through increased insulin secretion, induces upregulation of GH receptor and increases IGF-I secretion despite low GH secretion. 20,21 It is interesting to note that, in GH deficient obese adults, recombinant human GH (rhGH) treatment reduced visceral fat and metabolic abnormalities in patients with syndrome X.…”

Section: Introductionmentioning

confidence: 99%

Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men

et al. 2002

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OBJECTIVE:To investigate whether the changes in IGF-I concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat. DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: One-hundred and twelve Japanese overweight men aged 30 -59 y (body mass index (BMI) 28.4 AE 2.5 kg=m 2 ) and 33 normal-weight men aged 30 -39 y (BMI 22.1 AE 1.5 kg=m 2 ) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8 AE 2.8) were further enrolled into a 1 y exercise program. MEASUREMENTS: Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-I at baseline and after 1 y. RESULTS: In 112 overweight subjects at baseline, insulin (10.5 AE 5.0 mU=ml) and leptin (6.4 AE 3.7 ng=ml) significantly correlated with both V (r ¼ 0.260, P ¼ 0.0073; r ¼ 0.410, P < 0.0001) and S areas (r ¼ 0.377, P < 0.0001; r ¼ 0.613, P < 0.0001), respectively. IGF-I (156.8 AE 48.7 mU=ml) significantly and negatively correlated with V area (r ¼ 7 0.242, P ¼ 0.0125) and age (r ¼ 7 0.192, P ¼ 0.0480). In normal-weight men aged 30 -39 y (n ¼ 33) and age-matched subjects (n ¼ 30) selected from the 112 overweight men, the serum IGF-I further tightly correlated with V area (r ¼ 7 0.467, P < 0.0001). Visceral fat area and age were independently related to serum IGF-I levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224 AE 2781 to 7898 AE 4141 steps=day) and reduction of BMI (28.8 AE 2.8 to 27.7 AE 2.9). DIGF-I significantly correlated with DV area (r ¼ 7 0.432, P ¼ 0.0009) but not with DS area or DBMI. CONCLUSION: The present study indicated a negative correlation between IGF-I levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-I levels after an exercise intervention.

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Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients

Cited by 78 publications

References 34 publications

Association between Insulin-Like Growth Factor-I

Association between Insulin-Like Growth Factor-I

Impaired Glucose Tolerance and Bone Mineral Content in Overweight Latino Children With a Family History of Type 2 Diabetes

Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men

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