Relationships between Histopathology Type and Neoadjuvant Chemotherapy Response for Cervical Cancer Stage IB2 and IIA2

Muhammad, Syamel; Jamsari, Jamsari; Suharti, Netti; Hidayat, Yudi Mulyana; Khatimah, Gistin Husnul

doi:10.3889/oamjms.2020.4019

Cited by 2 publications

(3 citation statements)

References 33 publications

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“…However, only the difference in response to neoadjuvant chemotherapy at ER hormone receptors was statistically significant in this study (p = 0.025, OR = 4.5). 20 The distribution of results was similar to that of other researchers. Another study in Ki67, Prihantono et al In 2017 found that Ki67 had a strong positive correlation with neoadjuvant chemotherapy response, while Zhao et al found that Ki67 and HER2 could significantly predict disease free survival (DSF) and ER, PR, HER2-neu, Ki67 can predicted overall survival (OS).…”

Section: Discussionsupporting

confidence: 88%

“…In line with this study, Muhammad et al In 2020 also found a significant relationship between parity> 3 and response to neoadjuvant chemotherapy with an OR value of 10.8. 20 Fortner et al In 2019 also found the same thing where parity ≥ 3 had a worse chemotherapy response compared to patients with parity <3. Parity at risk increases the risk of negative hormone receptors that can worsen the response to neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 86%

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Accuracy of a Novel Scoring System for Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients

Qodir

Utami

Bahar

2021

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Background: Neoadjuvant chemotherapy (NAC) has become a widely accepted treatment option for locally advanced breast cancer (LABC). Furthermore, response to NAC is considered to be a predictor of favorable outcomes. It is known that some predictors are associated with NAC response. Objectives: To assess the accuracy of scoring system for prediction of response to neoadjuvant chemotherapy in LABC. Methods: Medical record of 50 patients received NAC at Mohammad Hoesin Hospital were retrospectively analysed between July 2019 to July 2020. Response of NAC in LABC was determined with Response Evaluation Criteria in Solid Tumours (RECIST). Variables of the scoring system are risk factors of breast cancer, immunohistochemical subtype, CD4+, CD8+, CD4+/CD8+ ratio, and neutrophil to lymphocyte ratio. Results: A total of 50 patients with LABC received and completed NAC. The mean age was 48.2 ± 11.0 at the time of diagnosis. Good response to NAC was achieved in 38 patients (76.0%). This scoring system shows a sensitivity of 77.8%, a specificity of 83.3%, a positive predictive value of 18.4%, and a negative predictive value of 24.4% with the Youden index of 66.1. The combination between less than three parity and positive estrogen receptor demonstrated better accuracy with a sensitivity of 96.3% and specificity of 77.7% and Youden index 74. Conclusion: This pilot study suggests that this scoring system is potentially useful for predicting response to neoadjuvant chemotherapy in LABC patients and warrants further investigation in a larger population to validate this finding.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 86%

Accuracy of a Novel Scoring System for Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients

Qodir

Utami

Bahar

2021

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“…17,20 Radiotherapy response can also be caused by other factors, including Hb level when diagnosed with cervical cancer, type of treatment (radiation or chemoradiation), and the degree of differentiation of histopathological types. 18,22,23 Acute toxicity are related to technique, total dose, volume, duration of radiation therapy, hygiene, and patient nutrition, including socioeconomic conditions. In this study, the most toxicity of external radiotherapy were hematological toxiciy (45.8%) followed by skin toxiciy (45.3%), gastrointestinal toxicity (6.3%) and urinary tract toxicity (2,6 %).…”

Section: Table 3 Response Analysis To External Radiotherapy Based On ...mentioning

confidence: 99%

Response of External Radiotherapy Alone in Stage IIB – IIIC Cervical Cancer Patients

Wibowo¹,

Laihad

Mongan

et al. 2022

Indones J Obstet Gynecol

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Objective: To investigate the therapeutic response and toxicity in cervical cancer patients with stage IIB-IIIC who undergo external radiation. Methods: This was a retrospective study using the medical records of the Obstetric Oncology and Radiotherapy Department at Prof. Dr. R. D. Kandou Hospital Manado. The research subjects were stage IIB-IIIC cervical cancer patients who underwent external radiation from September 2016 to December 2020. External radiation was administrated using 60Cobalt. The statistical analysis assessments in this study was carried out using descriptive analysis, while the analysis of the relationship was carried out using the Chi-Square method. The toxicity assessments were carried out from first day started external radiation up until 1 month after the therapy was deemed completed. Results : As many as 413 cervical cancer patients underwent external radiation during the study. However, only 192 cervical cancer patients with stage IIB-IIIC met the inclusion criteria in this study. The complete response to the therapy based on the findings was 65.6%, the partial response was 31.8%, the stable response was 1.6%, and the progressive response was 1%. In statistical analysis there was a significant association between cervical cancer stage and Overall Treatment Time with response to external radiotherapy. However, no significant association between tumor size and histopathological type with response to external radiotherapy. There were hematological toxicity (45.8%), skin toxicity (45.3%), gastrointestinal toxicity (6.3%) and urinary tract toxicity (2.6%). Conclusions: External radiotherapy response was a complete response where there was an association between cervical cancer stage and Overall Treatment Time with response to external radiotherapy, whereas there is no significant association found between the tumor size and histopathological type based on this research's findings. Most toxicity were hematology with complaints of anemia and thrombocytopenia Keywords: cervical cancer, external radiation response, toxicity. Abstrak Tujuan: Untuk mengetahui respon terapi dan efek samping pasien kanker serviks stadium IIB-IIIC yang menjalani radioterapi eksterna. Metode: Penelitian ini adalah penelitian deskriptif rektrospektif dengan menggunakan rekam medis Poli Onkologi Kandungan dan Instalasi Radioterapi RSUP Prof. Dr. R. D. Kandou Manado. Subyek penelitian adalah pasien kanker serviks stadium IIB-IIIC yang menjalani radiasi eksterna mulai September 2016 sampai Desember 2020. Radiasi eksterna dilakukan dengan sinar 60Cobalt. Penilaian analisis statistika pada penelitian ini menggunakan analisis deskriptif dan analisis hubungan menggunakan metode Chi Square. Penilaian efek samping dilakukan sejak hari pertama pasien memulai radiasi eksterna sampai 1 bulan setelah dinyatakan selesai menjalani radioterapi eksterna. Hasil: Selama periode penelitian didapatkan 413 pasien kanker serviks yang menjalani radiasi eksterna namun hanya 192 pasien kanker serviks stadium IIB-IIIC yang memenuhi kriteria inklusi pada penelitian ini. Respon terapi komplit sebesar 65,6%, respon terapi parsial sebesar 31,8%, respon terapi tidak berubah sebesar 1,6%, dan respon terapi progresif sebesar 1%. Pada analisis statistik terdapat hubungan bermakna stadium kanker serviks dan Overall Treatment Time dengan respon radioterapi eksterna, dan tidak terdapat hubungan bermakna ukuran tumor dan jenis histopatologi dengan respon radioterapi eksterna. Didapatkan efek samping hematologi (45,8%), efek samping kulit (45,3%), efek samping gastrointestinal (6,3%) dan efek samping traktus urinarius (2,6%). Kesimpulan: Respon radioterapi eksterna berupa complete response dimana terdapat hubungan bermakna antara stadium kanker serviks dan Overall Treatment Time dengan respon radioterapi eksterna. Tidak terdapat hubungan bermakna antara ukuran tumor dan jenis histopatologi. Efek samping terbanyak yaitu hematologi dengan keluhan berupa anemia dan trombositopenia. Kata kunci: efek samping, kanker serviks, respon radiasi eksterna.

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Relationships between Histopathology Type and Neoadjuvant Chemotherapy Response for Cervical Cancer Stage IB2 and IIA2

Cited by 2 publications

References 33 publications

Accuracy of a Novel Scoring System for Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients

Accuracy of a Novel Scoring System for Prediction of Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients

Response of External Radiotherapy Alone in Stage IIB – IIIC Cervical Cancer Patients

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