Relationships Between Histopathology Type and Neoadjuvant Chemotherapy Response in IB2 and IIA2 Cervical Cancer

Abstract

AbstrctBackground: Cervical cancer was the fourth common cancer in women in the world and the second most in Indonesia. Chemotherapy has been evaluated as a therapy strategies to treat stage IB2 and IIA2 cervical cancer. Neoadjuvant chemotherapy was still being a controversy for the chemotherapy resistance patient. This would delay the provision of definitive therapy. A marker is needed to identify patient which more relatively resistant to chemotherapy. Squamous Cell Carcinoma (SCC) type was known be have better response to neoadjuvant chemotherapy than non-Squamous Cell Carcinoma (nSCC) type, but there no studies at Dr.M.Djamil General Hospital yet on this matter before. Objective: To obtain the relationship between histopathology type and neoadjuvant chemotherapy response on cervical stage IB2 and IIA2 cervical canser. Method: This cohort analytic study conducted at Dr.M.Djamil Padang Hospital which obtained 35 samples of stage IB2 and IIA2 cervical cancer patients whom treated with neoadjuvant chemotherapy. Sampling was done by consecutive sampling technique. Results of histopathology and results of ultrasound examinations before and after given neoadjuvant chemotherapy were included to data. Data analysis used Chi-Square test. Results: CR + PR in the SCC and NSCC group were 32% and 50%, while SD + PD was 68% in SCC group and 50% in NSCC group. Conclusion: There was no significant relationship between histopathological type and neoadjuvant chemotherapy response to stage IB2 and IIA2 cervical cancer (p = 0.44). AbstrakLatar belakang: Kanker serviks menempati urutan keempat di seluruh dunia dan urutan kedua di Indonesia yang paling umum terjadi pada wanita. Kemoterapi telah dievaluasi sebagai salah satu strategi pengobatan kanker serviks stadium IB2 dan IIA2. Namun penggunaan kemoterapi neoadjuvant masih kontroversi pada pasien yang resisten dengan kemoterapi. Hal ini akan menunda pemberian terapi Volume 4, Nomor definitif, sehingga sangat penting untuk menemukan penanda yang dapat mengidentifikasi pasien mana yang relatif lebih resisten terhadap kemoterapi. Tipe squamous cell carcinoma (SCC) diketahui memiliki respon kemoterapi neoadjuvant yang lebih baik dibandingkan dengan non-squamous cell carcinoma (nSCC) namun belum ada penelitian yang dilakukan di RSUP M Djamil Padang mengenai hal ini sebelumnya. Tujuan: Untuk melihat Hubungan Tipe Histopatologi Dengan Respon Kemoterapi Neoadjuvant Pada Kanker Serviks Stadium IB2 Dan IIA2. Metode: Penelitian ini merupakan studi analitik cohort yang dilakukan di RSUP Dr. M. Djamil Padang pada 35 sampel pasien kanker serviks stadium IB2 dan IIA2 yang diberikan kemoterapi neoadjuvant. Pengambilan sampel dilakukan dengan teknik consecutive sampling. Data meliputi hasil gambaran histopatologi serta hasil pemeriksaan ultrasonografi sebelum dan sesudah diberikan kemoterapi neoadjuvant. Analisis data mengunakan uji Chi-Square. Hasil: CR+PR pada kelompok SCC adalah sebesar 32% dan NSCC adalah 50%, sedangkan SD+PD adalah sebesar 68 % pada kelompok SCC dan 50% pada kelompok NSCC. K...

Relationship between Serum Vascular Endothelial Growth Factor-A Levels and Response to Chemotherapy in Cervical Cancer

“…The after-effects of this study by Khatimah, (9) showed 35 subjects, of which 25 subjects (71,4 %) were squamous cell carcinoma type, followed by 10 subjects (28,6 %) in the adenocarcinoma group. The most common type of squamous cell carcinoma is found in around 80 % and 20 % of adenocarcinoma types, while other histological types are very rare in cervical cancer.…”