Relationships between epilepsy-related factors and memory impairment

Abstract

We may conclude that epilepsy-related dysfunctions in the temporal lobe are the dominant risk factor for developing memory problems, specifically verbal memory problems (verbal learning and problems consolidating verbal information), with more severe impairments with continuing seizures and when seizure frequency is high.

Autistic characteristics in adults with epilepsy

“…As previous research has shown, AEDs are known to impact on cognitive functioning; however this epilepsy group may be a higher functioning group with well-controlled epilepsy. Adults with chronic epilepsy recalled fewer items and this supports previous research by Hendriks, and these adults may represent a sub-group of individuals with poorer memory function within the sample (Hendriks et al, 2004).…”

“…Previous research has explored factors for impairments in semantic relational processing during a verbal free recall task in patients with TLE, and found that strength of memory functioning can vary according to lateralisation, frequency and type of seizures (Helmstaedter et al, 1997;Hendriks et al, 2004). However, the role of lateralisation has been challenged by recent fMRI neuroimaging study which demonstrated that lateralisation is not a key factor (Protzner & McAndrews, 2011).…”

Omega-3 polyunsaturated fatty acids in large doses attenuate seizures, cognitive impairment, and hippocampal oxidative DNA damage in young kindled rats

“…This can be attributed to the fact that, cognitive dysfunction induced by seizures is affected by many factors, including the site of focus localizations, seizure type, and the seizure duration and frequency [15]. PTZ kindling impairs cognitive functions in the objective location test, but has no significant effect on the Y-maze test in mice, reflecting the selective effect of PTZ kindling on cognitive functions [9].…”

Cognitive rehabilitation in epilepsy: An evidence-based review

“…The prevalence of memory impairment in patients with drug-resistant epilepsy is estimated around 20-50% (Halgren et al, 1991). Left TLE bears a significant risk of memory deficits compared with right TLE (Hendriks et al, 2004). Moreover, patients with long-lasting TLE may show a chronic cognitive deterioration (Hermann et al, 2008(Hermann et al, , 2010.…”