Relationships between Effects of Ag Nanoparticles and Ag Salt on Behavioral and Cognitive Functions of Mice and Ageing

Antsiferova, A. A.; Kopaeva, M. Yu.; Кашкаров, П. К.

doi:10.1134/s2635167622340018

Cited by 1 publication

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“…From the other point of view, as the changes of behavioral and cognitive functions of the mice exposed to silver citrate are compared to the controls, the imaginary improvement of their behavior might be considered as tigmotaxis impairment [30], the typical rodent behavior. However, from the other point of view, the improvement can also be considered as manifestation of ageing neutralization [31] by the perturbance in the form of silver citrate exposition.…”

Section: Discussionmentioning

confidence: 99%

Effects of Silver Citrate Prolonged Exposure on Behavioral and Cognitive Functions of Mice

Antsiferova,

Kopaeva,

Loginova

et al. 2023

Preprint

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Pure silver as well as silver compounds have been used as antiseptics for centuries. Nowadays, the most frequently applied form of silver is a nanoparticle form. Several studies demonstrate the ability of silver nanoparticles and silver salts to accumulate in the brain of laboratory ani-mals as well as the ability of silver nanoparticles to influence behavioral and cognitive functions of laboratory mammals. For the first time, the influence of a silver salt, in particular, silver citrate on the change dynamics of behavioral and cognitive functions of laboratory mice at the daily oral exposure during 30, 60, 120 and 180 days is investigated in the present research. We observed the anxiety increase after 30 days of the exposure as well as the ability of mice to adapt to the prolonged oral exposure of silver citrate manifested in the anxiety decrease, increase of locomotor activity and the tendency of long-term contextual memory improvement. Increase of locomotor activity and memory improvement might be associated with the sensitivity increase and regarded as compensatory mechanism to anxiety increase. The observed phenomenon is classified as a hormetic effect. A comparison with the analogous study implemented polyvi-nylpyrrolidone coated silver nanoparticles is carried out. It was concluded that the nanoform is more neurotoxic.

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Section: Discussionmentioning

confidence: 99%