Relationships between diffusing capacity for carbon monoxide (DLCO), and quantitative computed tomography measurements and visual assessment for chronic obstructive pulmonary disease

Nambu, Atsushi; Zach, Jordan; Schroeder, Joyce; Jin, Gong Yong; Kim, Song Soo; Kim, Yu-Il; Schnell, Christina; Bowler, Russell P.; Lynch, David A.

doi:10.1016/j.ejrad.2015.01.010

Cited by 47 publications

(41 citation statements)

References 31 publications

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“…The severity of COPD is currently graded by FEV1%, but it is often assessed by measuring DLco, [ 32 ] which was found to be more related to the number of small vessels in our study. Atsushi et al [ 33 ] found that the extent of emphysema was better correlated to DLco than to FEV1%. COPD involves multiple pathophysiological changes that may cause DLco to decrease, such as a reduction in the alveolar surface area, decreased perfusion, uneven ventilation, or inflammation or fibrosis of the alveolar wall impairing alveolar diffusion.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography quantification of pulmonary vessels in chronic obstructive pulmonary disease as identified by 3D automated approach

Wei²,

et al. 2016

Medicine

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The aim of this study was to investigate the vascular alteration of the whole lung and individual lobes in patients with COPD, and assess the association between pulmonary vessels and the extent and distribution of emphysema as well as pulmonary function by a 3-dimensional automated approach.A total of 83 computed tomography images from COPD patients were analyzed. Automated computerized approach was used to measure the total number of vessels at the fifth generation. The extent of emphysema (%LAA-950) in the whole lung and individual lobes were also calculated automatically. The association between the vascular number and the extent and distribution of emphysema, as well as the pulmonary function were assessed.Both the vascular number of fifth generation in the upper lobe and in the lower lobe were significantly negatively correlated with %LAA-950 (P < 0.05). Furthermore, there were significant, yet weak correlations between the vascular number and FEV1% predicted (R = 0.556, P = 0.039) and FEV1/FVC (R = 0.538, P = 0.047). In contrast, the vascular numbers were strongly correlated with DLco (R = 0.770, P = 0.003). Finally, the vascular number correlated closer with %LAA-950 of upper lobes than with %LAA-950 of lower lobes.Pulmonary vessel alteration can be measured; it is related to the extent of emphysema rather than the distribution of emphysema.

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Section: Discussionmentioning

confidence: 99%

Computed tomography quantification of pulmonary vessels in chronic obstructive pulmonary disease as identified by 3D automated approach

Wei²,

et al. 2016

Medicine

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“…We performed our retrospective cohort study using clinical and radiologic data from a study of chronic obstructive pulmonary disease (COPD) called the COPDGene study, which has been described elsewhere (10,12–15). Briefly, 10 306 smokers aged 45–80 years with at least a 10–pack-year history and a small number of never-smoking “healthy” individuals were enrolled at 21 clinical study centers in the United States between October 2006 and January 2011 and underwent baseline testing that included an extensive interview, volumetric non—contrast material–enhanced thin-section CT of the chest, and spirometry (12).…”

Section: Methodsmentioning

confidence: 99%

“…The ventricular volume measurements were obtained from prior work, and data in those individuals in whom the measurements could not be performed were excluded from our study (14). Finally, Dlco was measured at one COPDGene site (National Jewish Health, Denver, Colo) in a sample of convenience, and only individuals with Dlco measurements were included in our diffusing capacity analyses (15). The baseline COPDGene data set used for our study was generated on August 31, 2016.…”

Section: Methodsmentioning

confidence: 99%

Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort

Ash¹,

Harmouche

Ross

et al. 2018

Radiology

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Purpose To determine if interstitial features at chest CT enhance the effect of emphysema on clinical disease severity in smokers without clinical pulmonary fibrosis. Materials and Methods In this retrospective cohort study, an objective CT analysis tool was used to measure interstitial features (reticular changes, honeycombing, centrilobular nodules, linear scar, nodular changes, subpleural lines, and ground-glass opacities) and emphysema in 8266 participants in a study of chronic obstructive pulmonary disease (COPD) called COPDGene (recruited between October 2006 and January 2011). Additive differences in patients with emphysema with interstitial features and in those without interstitial features were analyzed by using t tests, multivariable linear regression, and Kaplan-Meier analysis. Multivariable linear and Cox regression were used to determine if interstitial features modified the effect of continuously measured emphysema on clinical measures of disease severity and mortality. Results Compared with individuals with emphysema alone, those with emphysema and interstitial features had a higher percentage predicted forced expiratory volume in 1 second (absolute difference, 6.4%; P < .001), a lower percentage predicted diffusing capacity of lung for carbon monoxide (Dlco) (absolute difference, 7.4%; P = .034), a 0.019 higher right ventricular–to–left ventricular (RVLV) volume ratio (P = .029), a 43.2-m shorter 6-minute walk distance (6MWD) (P < .001), a 5.9-point higher St George’s Respiratory Questionnaire (SGRQ) score (P < .001), and 82% higher mortality (P < .001). In addition, interstitial features modified the effect of emphysema on percentage predicted Dlco, RVLV volume ratio, 6WMD, SGRQ score, and mortality (P for interaction < .05 for all). Conclusion In smokers, the combined presence of interstitial features and emphysema was associated with worse clinical disease severity and higher mortality than was emphysema alone. In addition, interstitial features enhanced the deleterious effects of emphysema on clinical disease severity and mortality.

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“…COPD is defined as an obstruction of the airways that makes it hard to breathe. COHb levels were found to be significantly higher in COPD patients compared with the normal population [35,36]. Some COPD patients have a lower diffusing capacity for CO in the lungs [37][38][39].…”

Section: Chronic Obstructive Pulmonary Disease (Copd)mentioning

confidence: 99%

Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review

Pan

Leonardi

Croxford

2020

IJERPH

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Background: Carbon monoxide (CO) poisoning is an important public health issue around the world. Research indicates that many factors may be related to the rate of CO uptake and elimination in the human body. However, some factors related to CO uptake and elimination are considered controversial. Relatively little attention has been devoted to review and synthesis of factors affecting CO uptake and elimination. Purpose: This paper provides a critical scoping review of the factors and divides them into four aspects, including environmental, demographic, physiological and treatment factors. Methods: We searched the scientific databases for research that has proposed a mathematical equation as a synthesis of quantities related to CO poisoning, CO elimination, CO uptake, CO half-life, CO uptake and elimination and their relationships. After excluding the studies that did not meet the study criteria, there were 39 studies included in the review and the search was completed before 16 December 2019. Results and conclusion: This review discusses most of the factors that impact the rate of CO uptake and elimination. Several factors may be related to CO uptake and elimination, such as CO concentration, the duration of exposure to CO, age, sex, exercise, minute ventilation, alveolar ventilation, total haemoglobin mass and different treatments for CO poisoning. Although some potential factors were not included in the review, the findings are useful by presenting an overview for discussing factors affecting CO uptake and elimination and provide a starting point for further study regarding strategies for CO poisoning and the environmental standard of CO.

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Relationships between diffusing capacity for carbon monoxide (DLCO), and quantitative computed tomography measurements and visual assessment for chronic obstructive pulmonary disease

Cited by 47 publications

References 31 publications

Computed tomography quantification of pulmonary vessels in chronic obstructive pulmonary disease as identified by 3D automated approach

Computed tomography quantification of pulmonary vessels in chronic obstructive pulmonary disease as identified by 3D automated approach

Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort

Factors Contributing to CO Uptake and Elimination in the Body: A Critical Review

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