Relationships Between Aryl Hydrocarbon Hydroxylase Inducibility and Sensitivity to Chemically Induced Subcutaneous Sarcomas in Various Strains of Mice23

Kouri, Richard E.; Salerno, Ronald A.; Whitmire, Carrie E.

doi:10.1093/jnci/50.2.363

Cited by 90 publications

(18 citation statements)

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“…Contingent upon their environmental exposure to these sub strates, individuals with high inducibility may demonstrate enhanced metabolism, cytotoxicity and thereby harbor an increased risk for carcinogenesis. Futhermore, the ubiquitous distribution of these compounds in the urban environment may have profound importance in lung cancer epidemiology [3.4,5], In experimental animals, the AHH enzyme system can be induced using several different chemical substrates [6]. It has been shown that the level of AHH inducibility is genetically determined in certain strains of mice and that genetic inherit ance follows a dominant mode of transmission when using 3-methylcholanthrene as an inducer [7,8].…”

Section: Introductionmentioning

confidence: 99%

Aryl-Hydrocarbon Hydroxylase Activity in Lymphocytes from Lung Cancer Patients and Normal Controls

Guirgis

Lynch²,

Mate

et al. 1976

Oncology

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A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell carcinoma and two adenocarcinoma) and eleven age- and sex-matched controls. Lung cancer patients exhibited considerably greater variation and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.

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Section: Introductionmentioning

confidence: 99%

Aryl-Hydrocarbon Hydroxylase Activity in Lymphocytes from Lung Cancer Patients and Normal Controls

Guirgis

Lynch²,

Mate

et al. 1976

Oncology

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“…Those strains in which hepatic AHH was highly inducible, were two-to-three times more sensitive to MC-induced tumorigenesis than the "noninducible" strains. This relationship was not observed after the subcutaneous injection of DMBA or benzo[a]pyrene (99). As in earlier observations (192) both compounds were much less tumorigenic than MC, and it was suggested that the relatively low dose and weak carcinogenic response may obscure enzyme differences between "inducible" and "noninducible" strains.…”

Section: Studies With Hydroxylase Inhibitors and In-mentioning

confidence: 48%

“…They attributed this effect to an increase in the effective concentration of the putative carcinogenic intermediate, ious mouse strains and susceptibility to tumorigenesis demonstrate the complexity of carcinogen activation and the need to define the problem for each polycyclic hydrocarbon. Kouri and co-workers (99) found a close correlation in 14 strains of mice of AHH inducibility and tumor incidence after the subcutaneous injection of 3-methycholanthrene (MC). Those strains in which hepatic AHH was highly inducible, were two-to-three times more sensitive to MC-induced tumorigenesis than the "noninducible" strains.…”

Section: Studies With Hydroxylase Inhibitors and In-mentioning

confidence: 99%

Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

Wiebel

Gelboin

1977

Comprehensive Physiology

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“…AHHinducible mouse strains were more sensitive than the AHH-noninducible mouse strain in terms of tumor induction by PAH. [16][17][18] These findings suggest that the induction of tumors by PAH will be clearly correlated to their metabolic activation by AHH. We have compared AHH-inducible mice (BALB/c and C57BL/6) with AHH-noninducible mice (DBA/2) in terms of the results in the mouse bone marrow micronucleus assay, 2-stage skin carcinogenesis test 19) and single cell gel electrophoresis (SCGE) assay 20,21) using 7,12-dimethylbenz[a]anthracene (DMBA) as a reference carcinogen.…”

Section: The Induction Of a Micronucleus By Carcinogenic Substancesmentioning

confidence: 93%

Short-Term Screening Method for the Prediction of Carcinogenicity of Chemical Substances. Current Status and Problems of an in vivo Rodent Micronucleus Assay.

Sato

Tomita

2001

JOURNAL OF HEALTH SCIENCE

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Various short-term screening methods have been developed to detect mutagenic/carcinogenic substances. They have played important roles not only in screening suspected chemicals but in studying the mechanisms of mutagenesis/carcinogenesis, and have provided useful information for assessing the genetic effects of chemicals on humans. The micronucleus assay is an in vivo mammalian methods, which has been widely used for screening the genotoxic potency of chemical substances. By this assay, the genotoxicity of chemicals, including clastogens and spindle poisons, have been evaluated using immature bone marrow erythrocytes in mice. The use of immature erythrocytes in circulating peripheral blood instead of in bone marrow of mice has been developed in recent years and it has been determined that it gives results as relevant as those of bone marrow cells in mice. Using the peripheral blood of mice has made the micronucleus assay method more practical and useful. Recently, rats have been identified as an acceptable species for this assay, and assays using the peripheral blood of rats are often carried out concomitantly with general toxicity or carcinogenic studies. However, it must be noted that the micronucleus assays have some limitations. The activity of substances which are metabolized rapidly in mice or rats, for example, may hardly be detected by the micronucleus assay; metabolic features of the substances may affect the assay results greatly. In this review, the current status of the micronucleus assay is discussed as a short-term screening method in the context of its usefulness and its limitations.

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Relationships Between Aryl Hydrocarbon Hydroxylase Inducibility and Sensitivity to Chemically Induced Subcutaneous Sarcomas in Various Strains of Mice23

Cited by 90 publications

References 0 publications

Aryl-Hydrocarbon Hydroxylase Activity in Lymphocytes from Lung Cancer Patients and Normal Controls

Aryl-Hydrocarbon Hydroxylase Activity in Lymphocytes from Lung Cancer Patients and Normal Controls

Cutaneous Carcinogenesis: Metabolic Interaction of Chemical Carcinogens with Skin

Short-Term Screening Method for the Prediction of Carcinogenicity of Chemical Substances. Current Status and Problems of an in vivo Rodent Micronucleus Assay.

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