Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women

Lee, J H; Kim, S; Kim, M K; Yun, Bo Hyon; Cho, S; Choi, Young Sik; Lee, B S; Seo, Seok Kyo

doi:10.1080/13697137.2017.1395410

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…Vitamin D deficiency in cancer survivors impacts body composition, increasing the risk for both bone loss and even sarcopenia (97,102). Vitamin D levels are inversely correlated with sarcopenia in older adults, and vitamin D supplementation is now considered a possible treatment for improving muscle function in the elderly (103)(104)(105). The mechanism by which vitamin D improves physical function may be related to anti-inflammatory properties, through local production of the hormone calcitriol, the active metabolite of vitamin D 3 (101,106).…”

Section: Micronutrientsmentioning

confidence: 99%

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

Inglis

Lin

Kerns

et al. 2019

Nutrition and Cancer

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Cancer-related fatigue is a debilitating syndrome that persists for many cancer survivors for years after treatment. Symptoms include early and persistent fatigue, functional decline, depression and cognitive difficulties. Inflammation, assessed using pro-inflammatory biomarkers, is increased in cancer survivors with fatigue and treatments for fatigue are often aimed at reducing inflammation. Additionally, cancer and its treatment lead to nutritional complications, changes in body composition and nutritional deficiencies that potentially weaken the cancer survivor and impact cancer-related fatigue. We conducted a qualitative review of clinical trials that assessed nutritional interventions for preventing and treating cancer-related fatigue. Further studies were examined that used nutritional interventions to address inflammation and fatigue, due to the dearth of nutrition research directly related to cancer-related fatigue. Dietary intake prior to, during and after cancer treatment appears to affect fatigue levels. Increased protein intake may help preserve lean mass and body composition. Dietary patterns that reduce inflammation, such as the Mediterranean diet and other plant-based diets, appear tolerable to cancer survivors and may reduce fatigue. Supplementation with ginseng, ginger or probiotics may improve cancer survivors' energy levels. Nutritional interventions, alone or in combination with other interventions should be considered as therapy for fatigue in cancer survivors.

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Section: Micronutrientsmentioning

confidence: 99%

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

Inglis

Lin

Kerns

et al. 2019

Nutrition and Cancer

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“…Some researchers found insulin resistance inversely correlated with bone mineral density while other studies found insulin resistance causing smaller bone size and greater bone mineral density [23,48]. Insulin resistance and lower 25(OH)D levels in postmenopausal women also leads to muscle attenuation and sarcopenia [49,50].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of hemorheological parameters as biomarkers of calcium metabolism and insulin resistance in postmenopausal women

Farber

Dias

Freitas

et al. 2021

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Background: Calcium, vitamin D and insulin resistance are linked to osteoporosis and cardiovascular disease in menopause. Objective: Determine if hemorheological parameters related to blood viscosity in microcirculation are linked to calcium metabolism and insulin resistance in menopause. Methods: 25-Hydroxyvitamin D (25(OH)D)), 1, 25-dihydroxyvitamin D3 (1, 25(OH)2D), Parathyroid Hormone, ionized calcium, Glucose, Insulin and Hemoglobin A1c were measured in blood from 43 volunteers. Red blood cells (RBC) aggregation, RBC deformability and Whole Blood Viscosity were also performed. Results: 25(OH)D showed a positive correlation with RBC deformability 0.60 Pa. Subjects with 25(OH)D≤29.00 ng/mL had lower RBC deformability 0.60 Pa. and higher RBC Aggregation and higher HOMA-IR. Ionized calcium showed a negative correlation with RBC Aggregation. Subjects with ionized calcium ≤1.24 mmol/L showed higher RBC Aggregation. There was a positive correlation between HOMA-IR and RBC Aggregation and HOMA-IR showed a negative correlation with RBC deformability 0.30 Pa. Subjects with HOMA-IR <1.80 showed lower RBC aggregation and higher RBC deformability at 0.30 Pa, 0.60 Pa, 1.20 Pa, 3.0 Pa and 6.0 Pa. Conclusion: Low 25(OH)D, low ionized calcium and high HOMA-IR are related to impaired hemorheology in menopause. RBC aggregation and deformability can be used as biomarkers of calcium metabolism and insulin resistance in menopause.

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“…The effect was more significant for participants with low 25(OH)D concentration (<30 nmol/L) and for older participants (≥65 years). In addition, a cross-sectional study based on data from the South Korea National Health and Nutrition Examination Survey with postmenopausal Korean women showed that higher 25(OH)D concentration was associated with lower risk of sarcopenia [ 65 ].…”

Section: Role Of Nutrition In Healthy Ageing In Asiamentioning

confidence: 99%

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Inui¹,

Hanley

Tee

et al. 2021

Nutrients

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Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the proportion of aged people in the population is expected to double between 2017 and 2050. Increased life expectancy leads to an increase in non-communicable diseases, which consequently affects quality of life. Suboptimal nutritional status is a contributing factor to the prevalence and severity of non-communicable diseases, including cardiovascular, cognitive, musculoskeletal, immune, metabolic and ophthalmological functions. We have reviewed the published literature on nutrition and healthy ageing as it applies to the Asia-Pacific region, focusing on vitamins, minerals/trace elements and omega-3 fatty acids. Optimal nutritional status needs to start before a senior age is reached and before the consequences of the disease process are irreversible. Based on the nutritional status and health issues in the senior age in the region, micronutrients of particular importance are vitamins A, D, E, C, B-12, zinc and omega-3 fatty acids. The present paper substantiates the creation of micronutrient guidelines and proposes actions to support the achievement of optimal nutritional status as contribution to healthy ageing for Asia-Pacific populations.

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Relationships between 25(OH)D concentration, sarcopenia and HOMA-IR in postmenopausal Korean women

Cited by 11 publications

References 40 publications

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

Evaluation of hemorheological parameters as biomarkers of calcium metabolism and insulin resistance in postmenopausal women

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

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