Relationships Among the Histologic Pattern, Intensity, and Phenotypes of T Cells Infiltrating Renal Allografts

Kolbeck, Peter C.; Tatum, Arthur H.; Sanfilippo, Fred

doi:10.1097/00007890-198412000-00032

Cited by 28 publications

(8 citation statements)

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“…Thus, in the concept of transplant glomerulopathy [20,21], prominent glomerular infiltrates [4][5][6]8] and endotheliitis [9,21] have gradually been regarded as signs of an unfavorable prognosis. However, little has been published on the effect of pharmacological immunosuppression in the control of immunological rejection phenomena in situ [22], With regard to CsA, although intrarenal deposits of this drug have been associated with morphological phe nomena of nephrotoxicity [16,[23][24][25], no detailed de scriptions have appeared on the influence of intrarenal CsA deposits on the inflammatory infiltrate in the rejec tion reaction.…”

Section: Discussionmentioning

confidence: 99%

“…However, little has been published on the effect of pharmacological immunosuppression in the control of immunological rejection phenomena in situ [22], With regard to CsA, although intrarenal deposits of this drug have been associated with morphological phe nomena of nephrotoxicity [16,[23][24][25], no detailed de scriptions have appeared on the influence of intrarenal CsA deposits on the inflammatory infiltrate in the rejec tion reaction. A previous study [16] found no relation between CsA deposits and CD8-positive cytotoxic sup pressor lymphocytes which have been associated with a poor prognosis [5,6,8], However, the occurrence in heart and pulmonary transplant patients of rejection reactions with a poor prognosis, probably related to CsA resistance phenomena in CD4-positive lymphocytes and/or macro phages [17,18], has opened new research avenues. Drugresistant rejection, like in the development of multidrug resistance in neoplastic cells [26,27], is linked with the expression of glycoprotein p-170.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Intrarenal Deposits of Ciclosporin A on Acute Renal Transplant Rejection

Gómez‐Morales

Bustos

Montes

et al. 1995

Nephron

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Immunohistochemical techniques were used to study the presence of ciclosporin A (CsA) and leukocyte subsets in 36 posttransplant renal biopsy specimens histologically diagnosed as acute graft rejection. Glomeruli from patients with CsA deposits contained more leukocytes (p < 0.05) than glomeruli from tissues without deposits. In contrast, the interstitium from patients without deposits contained significantly more B lymphocytes than interstitia from kidneys with CsA deposits. In both glomeruli and interstitia, the CD4/CD8 ratios were higher in tissues without deposits, although the difference was not significant. The plasma levels of creatinine increased with the intensity of renal CsA deposits, and significantly more patients on hemodialysis had deposits as compared with patients not on hemodialysis. Our findings suggest two types of acute nonvascular rejection: (1) predominantly interstitial, with a good prognosis, characterized by low numbers of intrarenal CsA deposits and a predominance of B lymphocytes and (2) predominantly glomerular, with a poor prognosis, characterized by high levels of intrarenal CsA and a predominance of CD8-positive cells and macrophages.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Intrarenal Deposits of Ciclosporin A on Acute Renal Transplant Rejection

Gómez‐Morales

Bustos

Montes

et al. 1995

Nephron

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“…The matter is further complicated by the limited knowledge of the morphology in well-hctioning allografts. A few studies have shown significant infiltrates of inflammatory cells and parenchymal changes (32,79,116).…”

Section: Histologymentioning

confidence: 99%

Acute Kidney Graft Rejection Morphology and immunology

Andersen

1997

APMIS

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“…Immunohistochemical staining of organ transplant tissues with monospecific cell surface marker antibodies has given conflicting data on the CD4 and CD8 markers 1 of infiltrating T cells [11][12][13][14]. These studies have other limitations: (i) inability to correlate cell surface markers with functional characteristics of the cells in question, and (ii) presence of "irrelevant" mononuclear cell infiltrates in the absence of clinical rejection within the allograft [15,16].…”

Section: Introductionmentioning

confidence: 99%

Functional characterization of infiltrating T lymphocytes in human hepatic allografts

et al. 1986

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We have employed recently developed techniques in T-cell culturing to study the nature and function of infiltrating hepatic allograft T cells. Using the rationale that intragraft T cells are activated during cell mediated damage to the allograft, we were able to show that these cells would propagate and remain functionally active in the presence of the T-cell growth factor, IL-2. In several instances, phenotypic analysis of cells grown in this manner was very similar to that found within the graft. Both proliferative and cytotoxic responses could be detected from the cultured cell lines. The majority of the proliferative responses were donor-directed and immunogenetic analysis could define donor-directed HLA reactivity, to either class I or class II antigens, or both. Monoclonal anti-HLA antibodies inhibition profiles verified the apparent HLA reactivity. In a smaller percentage of cases, only IL-2 responsiveness could be detected, and no HLA reactivity could be determined. Cytotoxicity could be detected against both class I and class II antigens, however, those cells which demonstrated a greater magnitude of donor-directed cytotoxicity appeared to be directed against class I antigens. A significant correlation between donor-directed proliferation of biopsy cultured lymphocytes and cellular rejection was found. This model appears to be useful in delineating functions of the intragraft T-cell population during rejection.

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Relationships Among the Histologic Pattern, Intensity, and Phenotypes of T Cells Infiltrating Renal Allografts

Cited by 28 publications

References 0 publications

Influence of Intrarenal Deposits of Ciclosporin A on Acute Renal Transplant Rejection

Influence of Intrarenal Deposits of Ciclosporin A on Acute Renal Transplant Rejection

Acute Kidney Graft Rejection Morphology and immunology

Functional characterization of infiltrating T lymphocytes in human hepatic allografts

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