Relationships among stress, emotional intelligence, cognitive intelligence, and cytokines

Jung, Ye Ha; Shin, Na Young; Jang, Joon Hwan; Lee, Won Joon; Lee, Dong Hoon; Choi, Yoobin; Choi, Seong Hee; Kang, Do Hyung

doi:10.1097/md.0000000000015345

Cited by 38 publications

(27 citation statements)

References 48 publications

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“…In contrast, anti-inflammatory cytokines, such as interleukin (IL)-10, alleviate deleterious effects of cytokines on memory and plasticity [ 35 , 48 ], blocking for example the detrimental effects of lipopolysaccharide (LPS) or IL-1β on long-term potentiation (LTP) [ 26 , 35 , 42 ], and rescuing learning and memory deficits in inflammation-dependent models of Alzheimer’s disease [ 25 , 29 , 30 ]. Furthermore, a higher circulating IL-10 level has been associated with lower levels of self-reported stress as well as higher measures of cognitive function [ 24 ]. Consistent with this, IL-10 levels are reduced in major depressive disorder (MDD) patients [ 10 , 17 ] although not all [ 55 ], and IL-10 attenuates LPS-induced depressive-like behaviors in rats [ 11 ], whereas antidepressants increase IL-10 levels [ 31 , 33 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Worthen

Zighelboim

Jaramillo

et al. 2020

J Neuroinflammation

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Background: Major depressive disorder is a widespread mood disorder. One of the most debilitating symptoms patients often experience is cognitive impairment. Recent findings suggest that inflammation is associated with depression and impaired cognition. Pro-inflammatory cytokines are elevated in the blood of depressed patients and impair learning and memory processes, suggesting that an anti-inflammatory approach might be beneficial for both depression and cognition. Methods: We subjected mice to the learned helplessness paradigm and evaluated novel object recognition and spatial memory. Mice were treated with IL-10 intranasally or/and microglia cells were depleted using PLX5622. Statistical differences were tested using ANOVA or t tests. Results: We first established a mouse model of depression in which learning and memory are impaired. We found that learned helplessness (LH) impairs novel object recognition (NOR) and spatial working memory. LH mice also exhibit reduced hippocampal dendritic spine density and increased microglial activation compared to non-shocked (NS) mice or mice that were subjected to the learned helpless paradigm but did not exhibit learned helplessness (non-learned helpless or NLH). These effects are mediated by microglia, as treatment with PLX5622, which depletes microglia, restores learning and memory and hippocampal dendritic spine density in LH mice. However, PLX5622 also impairs learning and memory and reduces hippocampal dendritic spine density in NLH mice, suggesting that microglia in NLH mice produce molecules that promote learning and memory. We found that microglial interleukin (IL)-10 levels are reduced in LH mice, and IL-10 administration is sufficient to restore NOR, spatial working memory, and hippocampal dendritic spine density in LH mice, and in NLH mice treated with PLX5622 consistent with a procognitive role for IL-10. Conclusions: Altogether these data demonstrate the critical role of IL-10 in promoting learning and memory after learned helplessness.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Worthen

Zighelboim

Jaramillo

et al. 2020

J Neuroinflammation

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“…Moreover, they investigated associations between the emotional and cognitive components of intelligence. These relationships were different in persons depending upon the dominant right or left hemisphere (Jung et al, 2019).…”

Section: Resultsmentioning

confidence: 89%

Correlation between Emotional Intelligence and Academic Stress in Undergraduate Medical Students

Jamil¹

2020

HPEJ

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ABSTRACT: BACKGROUND: Students face health related issues and stress due to burden of their studies. Emotions can affect one’s reactions, therefore Emotional Intelligence may help overcome the negative effects of stressful situations faced by the students. OBJECTIVE: To determine the correlation between emotional intelligence (EI) and academic stress in undergraduate students. DESIGN: Cross-sectional Correlational study. SETTING: The study was conducted among the undergraduate student of M Islam Medical College Gujranwala. Two hundred and ten students participated in the study. METHODS: Schutte Emotional Intelligence and perceived stress scale proformas were given to participants and their EI and stress level was measured. RESULTS: Totally, 116 (55.2%) of participants were females and 94 (44.8%) were males. Perceived stress score was associated with gender and study of year. Perceived stress score was higher in female and second year undergraduate students. No significant difference was observed in emotional intelligence score between both genders and study of year. There was significant correlation between EI scores and educational stress in undergraduate students (p < 0.001). CONCLUSION: It is obvious from our study that the emotional intelligence scores and educational stress are negatively correlated. Educating students to improve EI may help prevent stress and optimize their overall wellness. Hence it is suggested that emotional intelligence awareness workshops and training be included in the educational programs of the undergraduate students.

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“…Interleukin-6 is a pro-inflammatory cytokine with wide-ranging biological effects. It has been previously implicated in neuroinflammation in the context of neuropsychiatric disorders and also appears to correlate with neurocognitive changes in the context of aging (Bradburn et al, 2017; Fominykh et al, 2018; Bobbo et al, 2019; Jung et al, 2019). Experimental manipulations of IL-6 signaling appear capable of producing related effects in animal models (Donegan et al, 2014, Hodes et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use

Angelis

Wendt²,

Pathak³

et al. 2020

Preprint

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Background: Alcohol drinking and tobacco smoking are hazardous behaviors associated with a wide range of adverse health outcomes, including many mental and physical disorders. Methods: To investigate the pleiotropic mechanisms linking these traits to cognitive and behavioral development, we explored the association of polygenic risk scores (PRS) related to drinks per week (DPW), age of smoking initiation (ASI), smoking initiation (SI), cigarettes per day (CPD), and smoking cessation (SC) with 433 neurodevelopmental features in 4,498 children and young adults of European ancestry from the Philadelphia neurodevelopmental cohort (PNC). This sample was not enriched for specific psychiatric traits, but 21% of the PNC participants endorsed substance use. Results: After applying a false discovery rate multiple testing correction accounting for the number of PRS and traits tested, we identified 36 associations related to psychotic symptoms, emotion and age recognition social competencies, verbal reasoning, anxiety-related traits, parents education, and substance use. These associations were independent of the genetic correlations among the alcohol-drinking and tobacco-smoking traits and those with cognitive performance, educational attainment, risk-taking behaviors, and psychopathology. The removal of participants endorsing substance use did not affect the associations of each PRS with neurodevelopmental traits identified as significant in the discovery analyses. Gene-ontology enrichment analyses identified several neurobiological processes underlying mechanisms of the PRS associations we report. These were mainly related to brain connectivity. Conclusions: We provide novel insights into the genetic overlap of smoking and drinking behaviors with neurodevelopment in children and young adults, highlighting their independence from psychopathology and other substance use.

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Relationships among stress, emotional intelligence, cognitive intelligence, and cytokines

Abstract: Supplemental Digital Content is available in the text

Cited by 38 publications

References 48 publications

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice

Correlation between Emotional Intelligence and Academic Stress in Undergraduate Medical Students

Drinking and smoking polygenic risk is associated with neurodevelopmental outcomes of children and young adults independently of psychopathology and substance use

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