Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions

Antypa, Niki; Cerit, Hilâl; Kruijt, Anne-Wil; Verhoeven, F.E.A.; Does, Willem Van der

doi:10.1016/j.neuroscience.2010.10.042

Cited by 27 publications

(36 citation statements)

References 69 publications

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“…A number of studies have identifi ed the contribution of the 5-HTTLPR polymorphism to variation in the recognition of emotions. Carriers of the S allele generally show better identifi cation of fear [5,14] but lag in terms of recognizing mimicked expressions during exposure to adverse environmental factors [42,49], which is consistent with views of the relationship of the S allele with more marked responses to environmental exposures [11].…”

supporting

confidence: 74%

“…These data indicate that in health, 5-HTTLPR is associated with enhanced processing of information on negative emotions, though this has not been supported by all authors [7,21,33]. Increased processing is apparent as an involuntary shift in attention towards faces expressing negative emotions, especially fear [5,10,20,50,59] and increased activation of the amygdala in response to presentation of angry and frightened faces [46,47]. Thus, healthy adult carriers of the S allele recognized fear better and joy worse [5,14].…”

Section: Resultsmentioning

confidence: 81%

“…The search for the mechanisms mediating the effects of the 5-HTTLPR polymorphism on the development of anxiety and depression led to the fi nding of elevated processing of emotionally negative information in carriers of the S allele, including facial expressions of fear and anger. Thus, the presence of the S allele in the genotype was found to be associated with increased activation of the amygdala on perception of frightened and angry faces [46,47] and a more marked negative shift (i.e., a tendency to involuntary focusing of attention on emotionally negative stimuli), as compared with homozygous carriers of the long (L) allele [5,10,20,50,59]. A number of studies have identifi ed the contribution of the 5-HTTLPR polymorphism to variation in the recognition of emotions.…”

mentioning

confidence: 92%

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Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Алфимова

Golimbet

Коровайцева

et al. 2015

Neurosci Behav Physi

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Existing data point to a link, within the general population, between polymorphic variants of the serotonin transporter gene (5-HTTLPR SLC6A4) and catechol-O-methyltransferase on the one hand and the processing of information related to emotional facial expressions on the other. Schizophrenia patients are characterized by a defi cit in the recognition of mimicked emotional expressions, which has adverse effects on their social adaptation. With the aim of seeking the molecular mechanisms of this defi cit, we have assessed the main and epistatic effects of these polymorphisms on the recognition of emotions among schizophrenia patients (n = 299) and healthy control subjects (n = 232). The 5-HTTLPR polymorphism showed a signifi cant relationship with the recognition of emotions by patients. Homozygotes for the long allele identifi ed facial emotions signifi cantly better than carriers of the short allele (F = 8.00, p = 0.005). Although the recognition of emotions in the patients group correlated with negative symptoms, verbal learning, and trait anxiety, these signs did not have signifi cant modifying infl uences on the association detected here. COMT was found to have no effect on the recognition of emotions either in normal subjects or in schizophrenia patients.

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supporting

confidence: 74%

Section: Resultsmentioning

confidence: 81%

mentioning

confidence: 92%

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Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Алфимова

Golimbet

Коровайцева

et al. 2015

Neurosci Behav Physi

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“…Highly alexithymic individuals perform poorly on a perception task of recognizing basic emotions associated with emotionally valenced sentences, words, faces and scenes [29][30][31] . A recent study revealed that S/S genotype subjects recognized negative facial expressions better than those with the L/L genotype in a Caucasian sample [32] . S allele carriers showed superior performance in the affective go/no-go task based on the emotional valence of words [33] .…”

Section: Discussionmentioning

confidence: 96%

Serotonin Transporter Gene Promoter Polymorphism and Alexithymia

Kano¹,

Mizuno²,

Kawano³

et al. 2012

Neuropsychobiology

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Background: Recent neurobiological studies have reported that alexithymia may result from altered brain function related to emotional processing. Serotonin (5-hydroxytryptamine, 5-HT) has been shown to regulate central nervous system development associated with psychological processing. We investigated the possibility that polymorphism of the 5-HT transporter-linked promoter region (5-HTTLPR) is associated with alexithymia. Methods: This study included 304 healthy Japanese volunteers (148 males, 156 females). The subjects were categorized according to genotype (L/L, L/S, S/S) and results of the 20-item Toronto Alexithymia Scale (TAS-20), State-Trait Anxiety Inventory (STAI) and Self-Rating Depression Scale (SDS). Results: Subjects with the L/L genotype showed significantly higher TAS-20 scores, as well as significantly higher scores on the difficulty identifying feeling (DIF) subscale, than those with the L/S or S/S genotype (p < 0.05). There was a gender difference in the association between 5-HTTLPR genotype and DIF score. Female subjects with the L/L genotype showed significantly higher DIF scores than those with the L/S or S/S genotype (p ≤ 0.001). Neither STAI nor SDS was significantly associated with the 5-HTTLPR genotype. Conclusion: These results suggest a link between low synaptic 5-HT and alexithymia.

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“…Finally, several studies found single-gene variant (e.g. COMT val 158 met, BDNF, and 5-HTTLPR) contributions to negative facial expression recognition in healthy subjects [4][5][6] . All of these studies pointed to the deep biological roots of facial emotion expression and recognition.…”

Section: Introductionmentioning

confidence: 99%

Genetic Variations in the Dopamine System and Facial Expression Recognition in Healthy Chinese College Students

Zhu

Chen²,

Moyzis

et al. 2012

Neuropsychobiology

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Objective: This study investigated the relation between genetic variations in the dopamine system and facial expression recognition. Methods: A sample of Chinese college students (n = 478) was given a facial expression recognition task. Subjects were genotyped for 98 loci [96 single-nucleotide polymorphisms (SNPs) and 2 variable number tandem repeats] in 16 genes involved in the dopamine neurotransmitter system, including its 4 subsystems: synthesis (TH, DDC, and DBH), degradation/transport (COMT,MAOA,MAOB, and SLC6A3), receptors (DRD1,DRD2,DRD3,DRD4, and DRD5), and modulation (NTS,NTSR1,NTSR2, and NLN). To quantify the total contributions of the dopamine system to emotion recognition, we used a series of multiple regression models. Permutation analyses were performed to assess the posterior probabilities of obtaining such results. Results: Among the 78 loci that were included in the final analyses (after excluding 12 SNPs that were in high linkage disequilibrium and 8 that were not in Hardy-Weinberg equilibrium), 1 (for fear), 3 (for sadness), 5 (for anger), 13 (for surprise), and 15 (for disgust) loci exhibited main effects on the recognition of facial expressions. Genetic variations in the dopamine system accounted for 3% for fear, 6% for sadness, 7% for anger, 10% for surprise, and 18% for disgust, with the latter surviving a stringent permutation test. Conclusions: Genetic variations in the dopamine system (especially the dopamine synthesis and modulation subsystems) made significant contributions to individual differences in the recognition of disgust faces.

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Relationships among 5-HTT genotype, life events and gender in the recognition of facial emotions

Cited by 27 publications

References 69 publications

Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Effects of the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene on the Recognition of Mimicked Emotional Expressions in Schizophrenia

Serotonin Transporter Gene Promoter Polymorphism and Alexithymia

Genetic Variations in the Dopamine System and Facial Expression Recognition in Healthy Chinese College Students

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