Relationship study between blood groups, rhesus factor and the risk of diabetes type 2 in a population of the Sidi Othmane district, Casablanca

Zahra, Kehailou Fatima; Mestaghanmi, Houriya; Jabari, Mohammed; Labriji, Ali; Amrani, S. El; Dibane, Ahmed

doi:10.1530/endoabs.63.p157

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“…Like other inherited traits, blood groups are genetically predetermined and may have an association with DM. [30] Though some studies have been conducted to investigate the possible association between blood group phenotypes and T2DM, the results are inconsistent and differed from one to another. In this study, the associations of different blood groups with T2DM were investigated.…”

Section: Discussionmentioning

confidence: 99%

The association of ABO and Rhesus blood groups with the occurrence of type 2 diabetes mellitus: A comparative cross-sectional study

Walle,

Tesfaye,

Getu

2023

Medicine

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Type 2 diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated levels of glucose in circulation which result from insufficient insulin or insulin resistance. The blood group of an individual is thought to be genetically predetermined and plays a vital role in increasing susceptibility to DM for particular blood groups. Therefore, this study aimed to determine the association between ABO and Rhesus blood groups with type 2 DM. A comparative cross-sectional study was conducted on 326 participants (163 type 2 DM patients and 163 age and sex-matched healthy individuals). Socio-demographic data were collected using a semi-structured questionnaire while Clinical data were extracted from the patient chart. A blood sample was collected from each study participant for ABO and Rhesus blood grouping. Chi-square test, bivariable, and multivariable logistic regression analysis were employed to indicate the association between different blood group types and type 2 DM. The current result showed that blood group O had the highest frequency among all study participants followed by blood groups B, A, and AB. Blood groups B and A were more common in the type 2 DM group compared with the control group while blood groups O and AB were more frequent in the control group. A chi-square test indicated that the ABO blood group had a significant association with type 2 DM while the Rhesus blood group was not associated with type 2 DM. Moreover, logistic regression analysis showed that B and O blood groups had a significant association with type 2 DM while A and AB blood groups had no association. The findings of this study indicated that type 2 DM has an association with the ABO blood group and has no association with the Rhesus blood group. Individuals with blood group B have a higher risk of developing T2DM (type II DM) as compared to other ABO blood groups.

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Section: Discussionmentioning

confidence: 99%