Relationship of ventricular ectopy to nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease

Shepard, John; Garrison, Michael; Grither, Debra A.; Evans, Robert G.; Schweitzer, Paula K.

doi:10.1016/0002-9343(85)90457-7

Cited by 109 publications

(56 citation statements)

References 20 publications

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“…[15][16][17][18][19] Oxygen therapy has been reported to improve potency in men with obstructive pulmonary diseases. Aasebo et al 20 reported a 42% reversal of ED in men with chronic obstructive pulmonary disease receiving a 1-month oxygen therapy.…”

Section: Discussionmentioning

confidence: 99%

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Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

et al. 2004

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The aim of this study was to compare the efficacy of sildenafil and continuous positive airway pressure (CPAP) in men with erectile dysfunction (ED) and obstructive sleep apnea syndrome (OSAS). In all, 30 men were randomly treated for 12 weeks either with sildenafil 100 mg before intercourse (15 men) or CPAP during night time sleep (15 men). Under sildenafil, 97/180 (53.9%) of attempted intercourses were successful compared to 33/138 (23.9%) under CPAP. The mean IIEF (erectile function domain score) was 12.9 and 9.3 after sildenafil and CPAP treatment, respectively (P ¼ 0.007), compared to 7.9 and 7 at baseline. In all, 53.3% of patients were satisfied with sildenafil and 20% with CPAP for ED treatment (P ¼ 0.058). Although sildenafil was superior to CPAP, comorbidities and OSAS per se possibly resulted in a lower effectiveness of sildenafil compared to that in the general population of ED men. While about half of the patients were not satisfied even with the more effective treatment, we conclude that a combination of the two therapeutic tools or a different therapeutic mode should be studied further.

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Section: Discussionmentioning

confidence: 99%

“…Men who agreed to be treated were randomly allocated, by a computer generation table of random numbers, to receive sildenafil 100 mg on demand 1 h prior to intercourse (15) or to be treated with CPAP at home during night time sleep (15). The therapeutic CPAP levels were determined during the full night of therapeutic titration.…”

Section: Methodsmentioning

confidence: 99%

Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

et al. 2004

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“…129 The concurrence of these two is associated with more cardiac dysrhythmias 130 and portends more severe pulmonary hypertension and right heart failure. 131 In one case series, pulmonary hypertension was observed in 86% of those with COPD comorbid with OSA (n = 17) compared to only 16% of patients with OSA but no COPD (n = 67).…”

Section: Impactmentioning

confidence: 99%

Sleep Disorders in Chronic Obstructive Pulmonary Disease: Etiology, Impact, and Management

Budhiraja

Siddiqi

Quan

2015

Journal of Clinical Sleep Medicine

151

125

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality and may frequently be complicated by sleep disorders. Insomnia and obstructive sleep apnea are commonly encountered in patients with COPD. Nocturnal hypoxemia is also prevalent in COPD may occur despite adequate awake oxygenation and can be especially severe in rapid eye movement sleep. Additionally, several factors-some of them unique to COPD-can contribute to sleep-related hypoventilation. Recognition of hypoventilation can be vital as supplemental oxygen therapy itself can acutely worsen hypoventilation and lead to disastrous consequences. Finally, accruing data establish an association between restless leg syndrome and COPDan association that may be driven by hypoxemia and/or hypercapnia. Comorbid sleep disorders portend worse sleep quality, diminished quality of life, and multifarious other adverse consequences. The awareness and knowledge regarding sleep comorbidities in COPD has continued to evolve over past many years. There are still several lacunae, however, in our understanding of the etiologies, impact, and therapies of sleep disorders, specifi cally in patients with COPD. This review summarizes the latest concepts in prevalence, pathogenesis, diagnosis, and management of diverse sleep disorders in COPD. Keywords: COPD, insomnia, obstructive sleep apnea, restless legs syndrome, hypoventilation Citation: Budhiraja R, Siddiqi TA, Quan SF. Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management. J Clin Sleep Med 2015;11(3):259-270.pii: jc-00080-14 http://dx.doi.org/10.5664/jcsm.4540 T hat sleep is adversely affected in chronic obstructive pulmonary disease (COPD) has been long recognized. 1 COPD affects 5% to 10% of the adult population in the United States and is a major contributor to global disease burden. 2 The prevalence of insomnia symptoms, insomnia disorder, restless leg syndrome, and hypoxemia is increased in COPD. [3][4][5] Furthermore, polysomnographic (PSG) evaluation generally reveals decreased sleep effi ciency and lower mean overnight oxygen saturation in COPD patients compared to controls. 6 In COPD, the pathogenesis of sleep disorders appears to be a complex and multifactorial process, likely consequent to one or more of the following: physiological changes associated with sleep, hypoxemia, hypercapnia, infl ammation, COPD medications, and/or nicotine use. Comorbid disorders as well as primary sleep disturbances may also contribute to disrupted sleep in COPD patients. For example, nocturnal gastroesophageal refl ux (GERD) is associated with both symptoms of sleep apnea and COPD, and may contribute to the pathogenesis, and concomitant occurrence of both disorders.7 GERD may also infl uence sleep quality which could potentially contribute to some of the sleep complaints reported by persons with COPD. 8 The following sections describe the diverse sleep disorders and sleep-related abnormalities encountered in patients with COPD. Sleep Disorders in Chronic Obstructiv...

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“…Tachycardia or other arrhythmia during nocturnal hypoxemia can result in pulmonary arterial hypertension. These events can also explain nocturnal desaturation (Shepard et al, 1985;Coccagna & Lugaresi, 1978). By considering the fact that the reduction in arterial oxygen is correlated with the severity of the OSA, abnormal DI upon completion of the 6-MWT was expected in our patients, since they had moderate to severe OSA.…”

Section: Discussionmentioning

confidence: 65%

Can 6-minute walk test predict severity of obstructive sleep apnea syndrome?

Naghan

Aloosh

Torang

et al. 2017

Sleep Science Practice

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Relationship of ventricular ectopy to nocturnal oxygen desaturation in patients with chronic obstructive pulmonary disease

Cited by 109 publications

References 20 publications

Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

Erectile dysfunction in men with obstructive sleep apnea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure

Sleep Disorders in Chronic Obstructive Pulmonary Disease: Etiology, Impact, and Management

Can 6-minute walk test predict severity of obstructive sleep apnea syndrome?

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