Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes

Feghhi, Mostafa; Nikzamir, Abdolrahim; Esteghamati, Alireza; Mahmoudi, Touraj; Yekaninejad, Mir Saeed

doi:10.1016/j.trsl.2011.03.002

Cited by 20 publications

(22 citation statements)

References 32 publications

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“…Disease processes which have been shown to increase vascularity include, in particular, endocrine glands illness [24,25], acromegaly [19], pituitary adenomas [26,27], autoimmune thyroid disease, goitre, neoplasms [18,22] and eye disorders -retinopathy occurring in premature infants [18,28], diabetic retinopathy [18,20,21,[29][30][31], uveitis and other ocular illnesses. Angiogenesis commonly occurs in inflammatory diseases [18-20, 22, 24-27].…”

Section: Introductionmentioning

confidence: 99%

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Kajdaniuk¹,

Marek²,

Niedziołka-Zielonka³

et al. 2014

Endokrynologia Polska

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Section: Introductionmentioning

confidence: 99%

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Kajdaniuk¹,

Marek²,

Niedziołka-Zielonka³

et al. 2014

Endokrynologia Polska

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“…In addition, it has also been associated with an increased risk of developing diabetic macular edema [35]. On the other hand, the GG genotype of this polymorphism (compared with the CC genotype) has been found to be an independent predictor of PDR in other studies performed in Caucasian population [40, 41]. Finally, through Indian population, the CG genotype has been associated with DR [42, 43].…”

Section: Methods Of Literature Reviewmentioning

confidence: 99%

Genetics in Diabetic Retinopathy: Current Concepts and New Insights

Simó‐Servat

Hernández

Simó

2013

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There is emerging evidence which indicates the essential role of genetic factors in the development of diabetic retinopathy (DR). In this regard it should be highlighted that genetic factors account for 25-50% of the risk of developing DR. Therefore, the use of genetic analysis to identify those diabetic patients most prone to developing DR might be useful in designing a more individualized treatment. In this regard, there are three main research strategies: candidate gene studies, linkage studies and Genome-Wide Association Studies (GWAS). In the candidate gene approach, several genes encoding proteins closely related to DR development have been analyzed. The linkage studies analyze shared alleles among family members with DR under the assumption that these predispose to a more aggressive development of DR. Finally, Genome-Wide Association Studies (GWAS) are a new tool involving a massive evaluation of single nucleotide polymorphisms (SNP) in large samples. In this review the available information using these three methodologies is critically analyzed. A genetic approach in order to identify new candidates in the pathogenesis of DR would permit us to design more targeted therapeutic strategies in order to decrease this devastating complication of diabetes. Basic researchers, ophthalmologists, diabetologists and geneticists should work together in order to gain new insights into this issue.

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“…Moreover, several studies have so far reported an association between risk genotypes of the cytokine genes and PDR in type 2 diabetes (Table 5) [48–50, 59–63]. So far, however, none of the risk genotypes has been reported to be associated with PDR in more than one population, suggesting that studies of the same polymorphisms on different populations are needed.…”

Section: Gene Polymorphisms Of Cytokine Genes and Pdrmentioning

confidence: 99%

Candidate Genes for Proliferative Diabetic Retinopathy

Petrovič¹

2013

BioMed Research International

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Several candidate genes have been so far implicated in the pathogenesis of proliferative diabetic retinopathy (PDR) in subjects with type 2 diabetes. Since the principal pathogenetic mechanisms for diabetic retinopathy (DR) and PDR are different, the main pathogenetic mechanism in DR is increased vascular permeability, whereas in PDR the crucial pathogenetic mechanisms are fibrosis and neoangiogenesis. Due to that fact, different candidate genes are expected to be involved in the development of either DR or PDR. None of the candidate genes, however, can be fully and solely responsible for the development of PDR and for DR progression into PDR. Epigenetic mechanisms are expected to be involved in the pathogenesis of PDR as well. Gene polymorphisms responsible for PDR and epigenetic mechanisms responsible for PDR are reviewed in this paper.

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Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes

Cited by 20 publications

References 32 publications

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Genetics in Diabetic Retinopathy: Current Concepts and New Insights

Candidate Genes for Proliferative Diabetic Retinopathy

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