Relationship of type 1 diabetes to ancestral proportions and HLA DR/DQ alleles in a sample of the admixed Cuban population

Abstract

We found an association between European ancestry and type 1 diabetes in our sample, indicating the contribution of ethnicity to incidence differences. Previously reported associations of HLA DR/DQ alleles with disease are confirmed for the admixed Cuban population.

Echovirus Epidemics, Autoimmunity, and Type 1 Diabetes

“…Other epidemiological study suggested that differences in T1D incidence among countries of Latin America could be explained by the proportion of the Amerindian population in those countries (Collado-Mesa et al, 2004). Using ancestry informative markers, we have recently shown that ancestral proportions do influence T1D development (Diaz-Horta et al, 2010). Studies of this type allow evaluating the influence of genetic background in disease incidence considering a homogeneous distribution of environmental factors across a given admixed population.…”

“…In populations of European origin, the threelocus haplotypes DRB1*04-DQA1*0301-DQB1*0302 and DRB1*03-DQA1*0501-DQB1*0201 have been shown to play a predominant role in conferring disease susceptibility (Fernando et al, 2008) being heterozygosity for both haplotypes the greatest known genetic risk for T1D. For the Cuban population, these haplotypes are also represented in subjects with T1D and they display odds ratios of 26 and 7.6, respectively (Diaz-Horta et al, 2010). On the other hand, DRB1*1501-DQA1*0102-DQB1*0602 is the haplotype conferring the highest protection for T1D in both European and Cuban populations.…”

“…In Cuba, www.intechopen.com population stratification exists because the population has been formed by admixture between subpopulations (mainly Spanish and West Africans) and admixture proportions (defined as the proportions of the genome that have ancestry from each subpopulation) vary between individuals (Hoggart et al, 2003). By utilizing ancestry informative markers, T1D-HLA associations were controlled for factors attributable to admixture or stratification of the population (Diaz-Horta et al, 2010). After controlling for individual admixture, HLA alleleand haplotype-T1D associations mentioned above remained significant indicating their consistence.…”

HLA-DRB1*1101 allele confer protection for Multiple Sclerosis disease in Cuban population

“…Diaz-Horta et al reported before an opposite association for diabetic Cuban patients. 23 Modest protective effects of HLA DRB1*01, DRB1*07, DRB1*10 were found among MS patients (OR 0.37, 0.2, 0.4 respectively).…”

“…10 In Cuba, in respect to another autoimmune disease, it was confirmed that T1DM was associated with a preponderant genome proportion of European ancestry after ADMIXMAP evaluation. 23 Toro et al have been studied the low prevalence of MS in Bogota, Colombia which present highly admixed population and have reported that HLADRB1*15 allele confers susceptibility to MS whereas HLA-DRB1*14 allele exerted resistance to disease. 29 Results from the present study have defined another allele, HLA-DRB1*1101, associated to the disease, mainly in Caucasian patients.…”