Relationship of total serum IgE levels in cord and 9‐month sera of infants

Halonen, Marilyn; Stern, Debra A.; Lyle, Sara K.; Wright, Anne L.; Taussig, Lynn M.; Martínez, Fernando D.

doi:10.1111/j.1365-2222.1991.tb00836.x

Cited by 81 publications

(52 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that it may be an early marker of allergic sensitisation. FeNO is strongly associated with atopy in children, even in the absence of disease [9], and there is evidence that pre-natal and early life exposure to ETS increases the risk of allergic sensitisation in young children [22,23], although the data are not consistent [24]. Another explanation is that FeNO reflects the acute irritant effects of exposure to ETS in this age group [13].…”

Section: Discussioncontrasting

confidence: 39%

Parental smoking increases exhaled nitric oxide in young children

Franklin¹

2006

European Respiratory Journal

View full text Add to dashboard Cite

The present study investigated the association between reported parental smoking and exhaled nitric oxide fraction (FeNO) in young children.In total, 78 children (24 females, mean age 51.3 weeks) were recruited. Fourteen lived with one smoking parent and eight with two smoking parents. FeNO was measured using the modified single-breath technique.Mean¡SD FeNO levels were 33.0¡18.9, 38.3¡15.0 and 48.3¡14.7 ppb for children with no, one and two smoking parents, respectively. There was a significant linear trend across the groups and, after controlling for other relevant factors, a significant difference between the groups.In the present study, exposure to environmental tobacco smoke was associated with increased exhaled nitric oxide fraction in young children. Furthermore, there was evidence of a doseresponse relationship between childhood exhaled nitric oxide fraction and the number of smoking parents.

show abstract

Section: Discussioncontrasting

confidence: 39%

Parental smoking increases exhaled nitric oxide in young children

Franklin¹

2006

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…The biological plausibility of this effect is similar to that mentioned for active smoking. Most data in the literature concern foetal or child-adolescent populations exposed to parental smoking and they show controversial results: while some authors did not find an association between IgE levels and passive smoking [17,18], the majority did find such an association [15,16,34]. Therefore, further studies are needed, especially in adults and possibly with confirmation of self-reported passive smoking exposure by objective methods (e.g.…”

Section: Discussionmentioning

confidence: 97%

“…Cigarette smoking is related to elevated levels of total serum IgE [1,12,13], but there are controversies about the pathogenetic mechanism [2,14]. Inconsistent results have been reported on the association of total serum IgE with passive smoking [15][16][17][18]. OMENAAS et al [3] and SHIRAKAWA et al [6] reported a positive association between work exposure and total serum IgE.…”

mentioning

confidence: 85%

See 1 more Smart Citation

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Sapigni¹,

Biavati²,

Simoni³

et al. 1998

Eur Respir J

View full text Add to dashboard Cite

The purpose of the present study was to analyse whether sex, age, skin test reactivity, cigarette smoking and occupational exposure were related to the total serum immunoglobulin (Ig)E concentrations (kU x L[-1]), in a general population sample. We studied 1,905 subjects (915 males, 990 females) of a general population sample (n=2,841, 8-73 yrs) participating in the second cross-sectional respiratory epidemiological survey in the rural Po Delta area (near Venice, North Italy). Distribution of total serum IgE concentrations was skewed, thus a log-transformation was performed to obtain a Gaussian shape. Significantly higher values of IgE were found in males compared to females. In general, a peak of IgE concentration was found at 8-14 yrs. IgE values tended to be lower in older than younger adults. Significantly higher serum IgE levels were shown in subjects with a positive skin-prick test index (ST+) than in those with a negative skin-prick test index (ST-). There was a significant relationship of total IgE levels with skin reactivity to pollens and house-dust mites. In both sexes higher values of IgE were found in current smokers than in ex-nonsmokers, regardless of skin-test reactivity. There was no significant difference in IgE values between ex- and nonsmokers. Passive smoking and occupational exposure were significantly related to increased IgE values. Our results confirm that in a general population sample immunoglobulin E concentrations are related not only to skin-prick test reactivity to common aeroallergens, but also to other risk factors for chronic obstructive lung diseases, such as sex, active/ passive smoking and occupational exposure.

show abstract

“…Studies of cord serum IgE levels were the first to examine the effects of maternal smoking on foetal immunology, but did not produce consistent results. Although a study in 1986 reported that cord serum IgE was increased in newborns if the mother smoked [13], many subsequent studies have not confirmed this [14][15][16]. A comprehensive longitudinal study did not find an effect of ETS on the development of atopy in early life [17].…”

mentioning

confidence: 96%

Adverse effects of maternal smoking during pregnancy on innate immunity in infants

Souëf¹

2006

European Respiratory Journal

View full text Add to dashboard Cite

T he potentially fatal effects of maternal smoking on infants have been recognised since the 1800s [1]. In the latter half of the 1900s, the link between maternal smoking and the increased rate of lower respiratory infection (LRI) in early life was described [2]. Given the high rates of smoking in many societies [3], the burden of the increase in LRI is substantial. In a meta-analysis of relationships between parental smoking and respiratory disease, LI et al. [4] calculated that the odds ratio (OR) for hospitalisation of LRI in infancy or early childhood for those exposed to parental environmental tobacco smoke (ETS) compared with those not exposed was 1.93 (95% confidence interval (CI) 1.66-2.25). The risk was age related, as the ORs of prevalence of serious LRI were 1.71 (95% CI 1.33-2.20) and 1.25 (95% CI 0.88-1.78) for children aged 0-2 and 3-6 yrs, respectively. LI et al. [4] concluded that the results of community and hospital studies were broadly consistent, and showed that the child of a parent who smokes is at approximately twice the risk of having a serious respiratory tract infection requiring hospitalisation in early life. Indeed, early respiratory infection is not only a major cause of morbidity in developed countries, but, in developing countries, respiratory infection is also the leading cause of death in children [5].There have been a large number of studies showing the relationships between maternal smoking and impaired lung function and increases in respiratory symptoms in infants and young children. An effect of maternal smoking on neonatal lung function has been demonstrated in a study performed very soon after birth [6]. In addition, maternal smoking has been associated with increased wheeze [7] in early life and in schoolchildren [8]. However, few studies have been large enough to separate the effects of placental-borne exposure during pregnancy and breast milk, and air-borne exposure after delivery. Studies that have been able to do this have concluded that the most important deleterious effects have occurred before birth. In a cohort study of 12,743 children from the UK, admission rates for lower respiratory diseases in children born to mothers who stopped smoking during pregnancy were as high as in children whose mothers smoked both during and after pregnancy [9]. Admission rates for lower respiratory diseases in children whose mothers smoked only post-natally were no higher than in those with nonsmoking mothers. Post-natal exposure exerted a significant influence on the incidence of bronchitis, but less than the effect of in utero exposure. For impairment in lung function in schoolchildren, similar conclusions regarding in utero versus post-natal exposure were reached by a more recent Californian study of 3,357 children [10]. In 5,762 subjects from the same Californian study, maternal smoking during, but not after, pregnancy was associated with an increased incidence of asthma [11].Thus, the previous studies have established that maternal smoking during pregnancy exerts a highly delete...

show abstract

Relationship of total serum IgE levels in cord and 9‐month sera of infants

Cited by 81 publications

References 17 publications

Parental smoking increases exhaled nitric oxide in young children

Parental smoking increases exhaled nitric oxide in young children

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

Adverse effects of maternal smoking during pregnancy on innate immunity in infants

Contact Info

Product

Resources

About