Relationship of TNF-α Gene Polymorphism with fat-tail Measurements (fat-tail dimensions (and wool weights in fat-tail Makooei breed of Iranian sheep

Tissue expression and variation analysis of three bovine adipokine genes revealed their effect on growth traits in native Chinese cattle

“…According to Cattle QTL Database, we found some QTL associated with production, meat and carcass traits were located in chromosome regions intersected with these three genes (Table S6). Previous studies also showed that polymorphisms within LEP were associated with growth and meat quality traits in bovine (Carvalho et al, 2012;Machulskaya, Kovalyuk, Gorkovenko, Shakhnazarova, & Morkovkina, 2017;Negahdary et al, 2014). For TNF, only sporadic reports have shown that polymorphisms of TNF could be strongly related to reproductive traits (Shirasuna et al, 2011).…”

“…We then identified five SNPs in three adipokine genes. The SNP1 led to a substitution of Cys25Arg, which lies within the α‐helix of LEP and is precisely the binding site of LEP receptor (Negahdary et al., ). So a change between two very different amino acids such as Cys and Arg might have some detrimental effect on the interaction.…”

“…In domestic animals, several studies have demonstrated that variations in LEP were associated with carcass fat content and growth traits (Carvalho et al, 2012;Wang et al, 2015). Studies in pigs and sheep found that TNF SNPs were associated with fatness and fat thickness (Negahdary, Majdi, Biabani, & Hajihosseinlo, 2014). In bovine, 533 SNPs of TNF were found in the dbSNP database, but the validation status for most of them is largely unknown.…”