Relationship of TMJ osteoarthritis / osteoarthrosis to head posture and dentofacial morphology

Ioi, Hideki; Matsumoto, Ryusuke; Nishioka, Masato; Goto, TK; Nakata, Satoshi; Nakasima, Akihiko; Al, Counts

doi:10.1111/j.1601-6343.2008.00406.x

Cited by 20 publications

(18 citation statements)

References 47 publications

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“…Dental malocclusion can cause OA in temporomandibular joint (TMJ). (16,17) In rodents, anterior cross-bite (UAC) imposed by dental prosthetics produces OA lesions in their TMJ cartilage as indicated by accelerated chondrocyte terminal differentiation and degradation of extracellular matrix. (18)(19)(20) Herein, we first investigated the impact of biomechanical stresses on CaSR expression and terminal cell differentiation by studying the effect of fluid flow shear stress (FFSS) on isolated TMJ chondrocytes and chondrogenic ATDC5 cells.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

Zhang

Yang

Wan

et al. 2018

Journal of Bone and Mineral Research

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Traumatic joint injuries produce osteoarthritic cartilage manifesting accelerated chondrocyte terminal differentiation and matrix degradation via unknown cellular and molecular mechanisms. Here we report the ability of biomechanical stress to increase expression of the calcium‐sensing receptor (CaSR), a pivotal driver of chondrocyte terminal differentiation, in cultured chondrogenic cells subjected to fluid flow shear stress (FFSS) and in chondrocytes of rodent temporomandibular joint (TMJ) cartilage subjected to unilateral anterior cross‐bite (UAC). In cultured ATDC5 cells or TMJ chondrocytes, FFSS induced Ca2+ loading and CaSR localization in endoplasmic reticulum (ER), casually accelerating cell differentiation that could be abrogated by emptying ER Ca2+ stores or CaSR knockdown. Likewise, acute chondrocyte‐specific Casr knockout (KO) prevented the UAC‐induced acceleration of chondrocyte terminal differentiation and matrix degradation in TMJ cartilage in mice. More importantly, local injections of CaSR antagonist, NPS2143, replicated the effects of Casr KO in preventing the development of osteoarthritic phenotypes in TMJ cartilage of the UAC‐treated rats. Our study revealed a novel pathological action of CaSR in development of osteoarthritic cartilage due to aberrant mechanical stimuli and supports a therapeutic potential of calcilytics in preventing osteoarthritis in temporomandibular joints by targeting the CaSR. © 2018 American Society for Bone and Mineral Research.

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Section: Introductionmentioning

confidence: 99%

Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

Zhang

Yang

Wan

et al. 2018

Journal of Bone and Mineral Research

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“…Altered function can lead to TMJ overloading, which is one of the main causes of osteoarthritis, also referred to as degenerative joint disease, a common arthritis affecting the TMJ. 3,4 According to research diagnostic criteria for temporomandibular disorders (RDC/ TMD), 5,6 a widely used diagnostic system for TMD, there are numerous scoring options used to evaluate the condition of osseous structures of the TMJ associated with osteoarthritis. 5,6 The hard tissue components of the TMJ, the mandibular condyle and the fossa/eminence, are assessed for features that indicate remodelling or degenerative changes of the bone.…”

mentioning

confidence: 99%

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

Krisjane

Urtane

Krumina

et al. 2012

International Journal of Oral and Maxillofacial Surgery

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“…At the end of the process, through the selection by full text, a total of 15 studies were considered 5 - 19 . Later, 5 more studies were included through manual search 21 , 22 , 50 - 52 . Therefore, 20 studies in total were reviewed in the present study.…”

Section: Resultsmentioning

confidence: 99%

Static body postural misalignment in individuals with temporomandibular disorders: a systematic review

Chaves¹,

Turci²,

Pinheiro³

et al. 2014

Braz. J. Phys. Ther.

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BACKGROUND: The association between body postural changes and temporomandibular disorders (TMD) has been widely discussed in the literature, however, there is little evidence to support this association. OBJECTIVES: The aim of the present study was to conduct a systematic review to assess the evidence concerning the association between static body postural misalignment and TMD. METHOD: A search was conducted in the PubMed/Medline, Embase, Lilacs, Scielo, Cochrane, and Scopus databases including studies published in English between 1950 and March 2012. Cross-sectional, cohort, case control, and survey studies that assessed body posture in TMD patients were selected. Two reviewers performed each step independently. A methodological checklist was used to evaluate the quality of the selected articles. RESULTS: Twenty studies were analyzed for their methodological quality. Only one study was classified as a moderate quality study and two were classified as strong quality studies. Among all studies considered, only 12 included craniocervical postural assessment, 2 included assessment of craniocervical and shoulder postures,, and 6 included global assessment of body posture. CONCLUSION: There is strong evidence of craniocervical postural changes in myogenous TMD, moderate evidence of cervical postural misalignment in arthrogenous TMD, and no evidence of absence of craniocervical postural misalignment in mixed TMD patients or of global body postural misalignment in patients with TMD. It is important to note the poor methodological quality of the studies, particularly those regarding global body postural misalignment in TMD patients.

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Relationship of TMJ osteoarthritis / osteoarthrosis to head posture and dentofacial morphology

Abstract: These results suggest that an association may exist between TMJ OA, head posture and dentofacial morphology.

Cited by 20 publications

References 47 publications

Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

The prevalence of TMJ osteoarthritis in asymptomatic patients with dentofacial deformities: a cone-beam CT study

Static body postural misalignment in individuals with temporomandibular disorders: a systematic review

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