Relationship of the Urticarial to the Inflammatory Reaction to Trichophytin

Marcussen, Poul V.

doi:10.1001/archderm.1937.01480030021003

Cited by 26 publications

(9 citation statements)

References 8 publications

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“…Three of the patients showed an immediate positive reaction, but their clinical profile was not in any significant way different from those who had negative reactivity. Negative or immediate positive reaction to trichophytin has generally been associated with chronic T. rubrum infections [3,9,15], The specificity of immediate reactivity to trichophytin is limited because it has also been observed in non-infected healthy individuals [15], in atopic individuals [11], in individuals with re current erysipelas-like eruptions [14] and in recurrent lymphangitis [6].…”

Section: Discussionmentioning

confidence: 99%

A Study of the Immunological Status of Patients with Dermatophytoses

Abraham¹,

Pandhi²,

Kumar³

et al. 1975

Dermatology

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22 patients with Trichophyton rubrum infection were studied for some of their immunological parameters. The trichophytin skin test performed with commercially available Dermatophytin (Hollister-Stier) gave immediate positive reaction in 3 patients. All the other patients gave negative delayed and retarded reactions. In vitro response to PHA of the peripheral lymphocytes was significantly depressed in patients as compared to the controls. No relationship could, however, be established between the severity, duration or extent of the disease and the depression of the lymphocyte response. IgG and IgA were found to be within normal limits. IgM levels were significantly depressed which was probably artefactual in nature.

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Section: Discussionmentioning

confidence: 99%

A Study of the Immunological Status of Patients with Dermatophytoses

Abraham¹,

Pandhi²,

Kumar³

et al. 1975

Dermatology

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“…Subjects with immediate hypersensitivity to trichophytin have been found to be more easily infected experimentally with Trichophyton mentagrophytes than are those without this type of response (132). Also, production of an immediate skin test response to trichophytin by passive transfer has been shown to block delayed reactions in patients who previously had only the delayed response (166). Delayed hypersensitivity reactions to trichophytin could be uncovered in some patients with chronic dermatophytosis by suppressing immediate reactions to this antigen via injections of antihistamines into the site (131).…”

Section: Dermatophytosismentioning

confidence: 99%

Cutaneous defenses against dermatophytes and yeasts

1995

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Predispositions to the superficial mycoses include warmth and moisture, natural or iatrogenic immunosuppression, and perhaps some degree of inherited susceptibility. Some of these infections elicit a greater inflammatory response than others, and the noninflammatory ones are generally more chronic. The immune system is involved in the defense against these infections, and cell-mediated immunity appears to be particularly important. The mechanisms involved in generating immunologic reactions in the skin are complex, with epidermal Langerhans cells, other dendritic cells, lymphocytes, microvascular endothelial cells, and the keratinocytes themselves all participating in one way or another. A variety of defects in the immunologic response to the superficial mycoses have been described. In some cases the defect may be preexistent, whereas in others the infection itself may interfere with protective cell-mediated immune responses against the organisms. A number of different mechanisms may underlie these immunologic defects and lead to the development of chronic superficial fungal infection in individual patients. Although the immunologic defects appear to be involved in the chronicity of certain types of cutaneous fungal infections, treatment of these defects remains experimental at the present time.

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“…Some patients with dermatophyte infections manifest immediate weal reactions to intradermal trichophytin. These reactions, seen more frequently in atopies and in persons infected with Trichophyton rubrum, can be passively transferred with sertmi, using the Prausnitz-Kiistner techtiique (Marcussen, 1937). The relationship of these reactions to delayed hypersensitivity and host resistance is unclear.…”

mentioning

confidence: 99%

Immunological reactivity in dermatophytosis

Hanifin

Ray

Lobitz

2006

British Journal of Dermatology

134

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SUMMARY Patients with Trichophyton mentagrophytes and T. rubrum infections were compared in terms of cutaneous responses and in vitro lymphocyte reactivity to trichophytin and other antigens. Twelve out of fourteen T. mentagrophytes patients exhibited delayed cutaneous hypersensitivity to trichophytin. Most T. rubrum patients (thirty‐seven out of forty‐nine) lacked delayed reactions to trichophytin specifically, but these patients frequently manifested immediate weal reactions to this antigen. Positive lymphocyte responses correlated with the presence of delayed but not immediate cutaneous reactions. Serum from chronic T. rubrum patients failed to inhibit lymphocyte responses. Possible mechanisms for selective anergy in chronic T. rubrum patients are discussed.

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Relationship of the Urticarial to the Inflammatory Reaction to Trichophytin

Cited by 26 publications

References 8 publications

A Study of the Immunological Status of Patients with Dermatophytoses

A Study of the Immunological Status of Patients with Dermatophytoses

Cutaneous defenses against dermatophytes and yeasts

Immunological reactivity in dermatophytosis

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