Relationship of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) to functional, emotional, and neuropsychological outcomes

O’Brien, Amanda R.; Gaudino-Goering, Elizabeth; Shawaryn, Marla A.; Komaroff, Eugene; Moore, Nancy B.; DeLuca, John

doi:10.1016/j.acn.2007.07.002

Cited by 84 publications

(104 citation statements)

References 47 publications

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“…Nonetheless, the remainder of null findings confirm the weak association between subjective and objective cognitive performance previously described in the literature. 12,14,15,22 In contrast, reports of cognitive concerns on the PDQ were highly correlated with concomitant reports of depression, anxiety, fatigue, and self-efficacy, in line with existing literature. 15,19,21 Among these variables, reports on the PDQ were most highly correlated with vegetative symptoms of depression (r = 0.60 to 0.66) addition, each index of the PDQ (ie, Attention, Memory, and Planning) maintained significant associations with each self-report factor.…”

Section: Resultsmentioning

confidence: 41%

“…Designed specifically for cognitive performance cite poor or nonexistent findings, generating concern over the clinical utility of self-report measures of cognition. 12,22 The current investigation aimed to 1) examine the relationship between subjective cognitive concerns on the PDQ and objective cognitive performance and 2) examine the relationship between reports on the PDQ and reports of depression, fatigue, anxiety, and self-efficacy. Based on the previous findings that noncognitive factors, such as emotional status, disease-related variables, and personality traits, may have a significant effect on one's perception of cognitive functioning, we hypothesized that there would be a stronger and more consistent relationship between cognitive concerns and these factors.…”

Section: Resultsmentioning

confidence: 99%

“…This cautionary provision was echoed in a subsequent investigation of the MSNQ, further raising the concern that the self-report of cognitive concerns may be more related to depressive symptoms than to objective cognitive performance, per se. 12 Thus, it has been recommended that other screening instruments (eg, depression measures) be administered when using self-report measures of cognitive functioning to determine the contribution of affective symptoms to cognitive concerns. 13 The PDQ was also developed specifically for MS to measure self-reported cognitive impairment and is part of the Multiple Sclerosis Quality of Life Inventory.…”

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confidence: 99%

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The Perceived Deficits Questionnaire

Strober¹,

Binder²,

Nikelshpur³

et al. 2016

International Journal of MS Care

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Background:Cognitive dysfunction affects approximately 43% to 70% of individuals with multiple sclerosis (MS) and is an important determinant of several functional outcomes in MS and quality of life. Brief neuropsychological test batteries have been developed specifically for use in MS and are widely used to aid clinicians in assessing levels of cognitive impairment in MS. Neuropsychologists and neurologists also frequently use briefer screening measures, such as the Perceived Deficits Questionnaire (PDQ), to assist in determining whether a more extensive neuropsychological evaluation is warranted. However, despite the ease of such measures, the relationship between self-report and objective cognitive impairment has been inconsistent, at best. Moreover, factors such as depression, fatigue, anxiety, and personality have been found to be more related to reports of cognitive difficulties. The purpose of the present study was to clarify the relationship between subjective cognitive concerns and objective cognitive impairment while accounting for related symptoms.

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Section: Resultsmentioning

confidence: 41%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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The Perceived Deficits Questionnaire

Strober¹,

Binder²,

Nikelshpur³

et al. 2016

International Journal of MS Care

View full text Add to dashboard Cite

show abstract

“…In MS, questionnaire-based methods and single, sensitive cognitive tests have been proposed for this purpose. The MS Neuropsychological Screening Questionnaire (MSNQ) has shown some promise in identifying patients at higher risk for neuropsychological and neuropsychiatric disorder , although only the informant or caregiver-report version is sufficiently sensitive and specific for targeting patients with cognitive impairment O'Brien et al 2007). Alternatively, single tests, which are easily administered and have strong concurrent validity such as the SDMT have been proposed to screen for cognitive impairment in patients with MS (Deloire et al 2006;Parmenter et al 2007c).…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

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In this manuscript, we review literature describing the neuropsychological and brain imaging characteristics of systemic lupus erythematosus (SLE) patients. The findings are compared and contrasted with multiple sclerosis (MS) studies, revealing similarities and differences of interest to clinicians and researchers. While cognitive impairment is somewhat less common in SLE than MS, the diseases share a similar cognitive profile with deficits most prominent on tests emphasizing the speed of information processing, working memory, and visual/spatial learning, and memory. In early or more mildly affected patients, diffuse white matter damage, which may not be apparent on conventional brain imaging, plays a major role in clinical presentation and cognitive testing. The causes of white matter damage are very different, however, and in later stages of the disease MS and SLE appear to give rise to different forms of cerebral pathology. MS may be characterized by increasing brain atrophy affecting especially the cortical and deep gray matter, at least after conversion to secondary progressive course. There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research. KeywordsSystemic lupus erythematosus; Multiple sclerosis; Cognition; Memory; Processing speed; MRI; Effect size Systemic lupus erythematosus (SLE) is a relapsing-remitting autoimmune disease with wide ranging organ involvement and clinical symptoms varying from mild and transient symptoms to death. Cognitive impairment is reported in SLE, even among those patients without documented or overt signs of central nervous system (CNS) involvement. Presumably, cognitive disorder is the result of underlying brain disease although the precise mechanisms remain to be elucidated. The prevalence and degree of cognitive impairment is also uncertain.In this article we will endeavor to evaluate the evidence for neuropsychological impairment in SLE, and to compare the findings with that of MS, another immunological disorder whose symptoms wax and wane and which affects women more than men. Unlike SLE, MS is a disease that always impacts the CNS, and the causes of cognitive disorder in MS are better understood.

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“…The results of the self-report version, however, were more related to measures of depression. 11 In addition to depression, other factors can influence subjective cognitive concerns. 12 Levels of anxiety, fatigue, and selfefficacy 12 have been found to shape perceived cognitive abilities, which suggests that attitudes, beliefs, and expectations regarding cognitive functioning are important variables that need to be addressed in treatment.…”

Section: The Cognitive Index: Composite Z Score Index Derived From Thmentioning

confidence: 99%

Screening Instruments for the Early Detection of Cognitive Impairment in Patients with Multiple Sclerosis

Kim

Zemon²,

Rath³

et al. 2017

International Journal of MS Care

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Relationship of the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) to functional, emotional, and neuropsychological outcomes

Cited by 84 publications

References 47 publications

The Perceived Deficits Questionnaire

The Perceived Deficits Questionnaire

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

Screening Instruments for the Early Detection of Cognitive Impairment in Patients with Multiple Sclerosis

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