Relationship of the mucosal microbiota to gastrointestinal inflammation and small cell intestinal lymphoma in cats

Garraway, Kayode; Johannes, Chad M.; Bryan, Angela; Peauroi, John R.; Rossi, Giacomo; Zhang, Min; Wang, Chong; Allenspach, Karin; Jergens, Albert E.

doi:10.1111/jvim.15291

Cited by 14 publications

(35 citation statements)

References 77 publications

(172 reference statements)

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“…Dogs with chronic enteropathy (CE) have been shown to have lower concentrations and altered patterns of SCFAs, as well as changes in the fecal microbiota compared to healthy dogs (Minamoto et al, 2019). With respect to cats, it has been shown that the GI microbiota in those with IBD is altered compared to healthy cats (Garraway et al, 2018). One study also found that Fusobacterium spp.…”

Section: Inflammatory Enteropathiesmentioning

confidence: 99%

“…One study also found that Fusobacterium spp. are elevated in the ileum and colon of biopsies from cats with small cell GI lymphoma compared to those with IBD; however, it’s not yet clear whether this change plays any role in the development of GI lymphoma ( Garraway et al, 2018 ). While a number of previous reviews have discussed this topic at length ( Heilmann and Allenspach, 2017 ; Redfern et al, 2017 ; Roth-Walter et al, 2017 ; Yogeshpriya et al, 2017 ; Barko et al, 2018 ), few authors have explicitly evaluated the impact of macronutrient nutrition (nutrition supplied by carbohydrates, protein, and fat), digestion, and food processing on the pet microbiome and its subsequent effect on health outcomes in IBD.…”

Section: Current Evidence: the Role Of Nutrition In Influencing Cat Amentioning

confidence: 99%

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The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

et al. 2020

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The gastrointestinal (GI) microbiome of cats and dogs is increasingly recognized as a metabolically active organ inextricably linked to pet health. Food serves as a substrate for the GI microbiome of cats and dogs and plays a significant role in defining the composition and metabolism of the GI microbiome. The microbiome, in turn, facilitates the host's nutrient digestion and the production of postbiotics, which are bacterially derived compounds that can influence pet health. Consequently, pet owners have a role in shaping the microbiome of cats and dogs through the food they choose to provide. Yet, a clear understanding of the impact these food choices have on the microbiome, and thus on the overall health of the pet, is lacking. Pet foods are formulated to contain the typical nutritional building blocks of carbohydrates, proteins, and fats, but increasingly include microbiome-targeted ingredients, such as prebiotics and probiotics. Each of these categories, as well as their relative proportions in food, can affect the composition and/or function of the microbiome. Accumulating evidence suggests that dietary components may impact not only GI disease, but also allergies, oral health, weight management, diabetes, and kidney disease through changes in the GI microbiome. Until recently, the focus of microbiome research was to characterize alterations in microbiome composition in disease states, while less research effort has been devoted to understanding how changes in nutrition can influence pet health by modifying the microbiome function. This review summarizes the impact of pet food nutritional components on the composition and function of the microbiome and examines evidence for the role of nutrition in impacting host health through the microbiome in a variety of disease states. Understanding how nutrition can modulate GI microbiome composition and function may reveal new avenues for enhancing the health and resilience of cats and dogs.

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Section: Inflammatory Enteropathiesmentioning

confidence: 99%

Section: Current Evidence: the Role Of Nutrition In Influencing Cat Amentioning

confidence: 99%

The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

et al. 2020

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“…Although the relationship between intestinal dysbiosis and colorectal cancer has been widely debated in humans, only a small number of studies have been focused on the correlation between bowel cancer and gut microbiota in dogs and cats and, what is more, with discordant results (Omori et al ., 2017; Garraway et al ., 2018; Gavazza et al ., 2018; Herstad et al ., 2018). However, while the relative abundance of the Fusobacterium genus and the Enterobacteriaceae family increased in ileum and colon biopsies from cats with small cell GI lymphoma (Garraway et al ., 2018), no differences of the abundance of these two bacterial taxa were observed in dogs affected by intestinal lymphoma when compared to the control (Omori et al ., 2017; Gavazza et al ., 2018; Herstad et al ., 2018) and even one study reported a decreased abundance of Fusobacterium spp. in canine lymphoma biopsies (Gavazza et al ., 2018).…”

Section: The Canine and Feline Gut Microbiota And Gi Diseasesmentioning

confidence: 99%

Catching a glimpse of the bacterial gut community of companion animals: a canine and feline perspective

Alessandri

Argentini

Milani

et al. 2020

Microbial Biotechnology

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Dogs and cats have gained a special position in human society by becoming our principal companion animals. In this context, efforts to ensure their health and welfare have increased exponentially, with in recent times a growing interest in assessing the impact of the gut microbiota on canine and feline health. Recent technological advances have generated new tools to not only examine the intestinal microbial composition of dogs and cats, but also to scrutinize the genetic repertoire and associated metabolic functions of this microbial community. The application of high-throughput sequencing techniques to canine and feline faecal samples revealed similarities in their bacterial composition, with Fusobacteria, Firmicutes and Bacteroidetes as the most prevalent and abundant phyla, followed by Proteobacteria and Actinobacteria. Although key bacterial members were consistently present in their gut microbiota, the taxonomic composition and the metabolic repertoire of the intestinal microbial population may be influenced by several factors, including diet, age and anthropogenic aspects, as well as intestinal dysbiosis. The current review aims to provide a comprehensive overview of the multitude of factors which play a role in the modulation of the canine and feline gut microbiota and that of their human owners with whom they share the same environment.

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“…There is a dynamic relationship between the immune system and microbiota. Intestinal mucosa, with Tolllike receptors, induces fall signal and provokes the production and the release of inflammatory mediators (cytokines, phagocytes) (Schmitz and Suchodolski, 2016;Garraway et al, 2018).…”

Section: Role Of the Physiological Gut Microbiotamentioning

confidence: 99%

Role of gut microbiota in dog and cat’s health and diseases

Mondo¹,

Marliani²,

Accorsi³

et al. 2019

Open Vet J.

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Mammalian gastrointestinal tract is colonized by a large number of microorganisms, known as gut microbiota, that play a key role in the physiological and pathological states. In particular, the gastrointestinal tract of dogs and cats harbors a complex and highly biodiverse microbial ecosystem. Recent studies see it involved in a wide range of life processes, including energy needs, metabolism, immunological activity, and neuro-behavioral development. This review focuses on the role of the microbiota on the health of pets and will discuss changes that occur in the disease.

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Relationship of the mucosal microbiota to gastrointestinal inflammation and small cell intestinal lymphoma in cats

Cited by 14 publications

References 77 publications

The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease

Catching a glimpse of the bacterial gut community of companion animals: a canine and feline perspective

Role of gut microbiota in dog and cat’s health and diseases

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