Relationship of the loose cough sign to daily sputum volume. Observer variation in its detection.

Hall, Graham J. L.; Gandevia, Bryan

doi:10.1136/jech.25.2.109

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…- Success of sputum induction influenced by inflammation [72]. - Variations in the amount of sputum produced [76]. - Not really applicable to animal models.Bronchoscopy- Direct sampling of mucus when used to remove plugs [77].…”

Section: Techniques For Measuring Mucus and Mucinmentioning

confidence: 99%

Strategies for measuring airway mucus and mucins

Atanasova

Reznikov

2019

Respir Res

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Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD). Studying mucus composition and its physical properties has therefore been of significant interest both clinically and scientifically. Yet, measuring mucus production, output, composition and transport presents several challenges. Here we summarize and discuss the advantages and limitations of several techniques from five broadly characterized strategies used to measure mucus secretion, composition and mucociliary transport, with an emphasis on the gel-forming mucins. Further, we summarize advances in the field, as well as suggest potential areas of improvement moving forward.

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Section: Techniques For Measuring Mucus and Mucinmentioning

confidence: 99%

Strategies for measuring airway mucus and mucins

Atanasova

Reznikov

2019

Respir Res

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“…Studies including people with respiratory conditions where chronic sputum production was likely to be a feature (CF, bronchiectasis, chronic bronchitis) were considered to represent the population where FET/ACBT is indicated. While chronic sputum production is a feature of these conditions, it is likely that there is considerable variation in sputum production both between and within populations, 18 with the range of reported daily sputum volume differing between people with chronic bronchitis (5 to >50ml), 19 and bronchiectasis (20e500ml). 20 To date, no information could be found which reported the average daily sputum volume in people with cystic fibrosis.…”

Section: Generalisability Of the Evidencementioning

confidence: 99%

The active cycle of breathing technique: A systematic review and meta-analysis

Lewis

Williams

Olds

2012

Respiratory Medicine

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“…A requested cough under observation was graded as loose (productive) or dry by its sound (Hall and Gandevia, 1971). …”

Section: Physical Signsmentioning

confidence: 99%

Peripheral pooling of bronchographic contrast material: evidence of its relationship to smoking and emphysema.

Musk¹,

Gandevia²,

Palmer³

1978

Thorax

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. Peripheral pooling of bronchographic contrast material: evidence of its relationship to smoking and emphysema. Sixty-six subjects, mainly derived from various occupational groups and one-third of whom admitted to dyspnoea on exertion, have been grouped according to the appearance of their peripheral airways at bronchography with oily propyliodone. Eleven subjects showed marked peripheral pooling of radiographic contrast material, 22 showed mild or moderate pooling, and in 33 peripheral pools were absent. Pooling was not seen in non-smoking subjects. In the group of subjects without pooling, pulmonary function in non-smokers and subjects with a history of smoking was similar. Subjects with marked pooling had a significantly lower pulmonary diffusing capacity (transfer factor) and evidence of loss of pulmonary elastic recoil when compared with subjects with absent peripheral pooling. These results indicate that bronchographic peripheral pooling is associated with the physiological changes of panacinar pulmonary emphysema and suggest that a causal relationship may exist between the organic bronchiolar lesion of pooling and the peripheral parenchymal lesion of panacinar emphysema.

show abstract

Relationship of the loose cough sign to daily sputum volume. Observer variation in its detection.

Cited by 14 publications

References 8 publications

Strategies for measuring airway mucus and mucins

Strategies for measuring airway mucus and mucins

The active cycle of breathing technique: A systematic review and meta-analysis

Peripheral pooling of bronchographic contrast material: evidence of its relationship to smoking and emphysema.

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