Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients

Kubysheva, Nailya; Postnikova, Larisa; Soodaeva, Svetlana; Novikov, V. V.; Eliseeva, T.I.; Batyrshin, Ildar; Li, Timur; Klimanov, Igor; Chuchalin, Alexander

doi:10.1155/2017/8216723

Cited by 3 publications

(2 citation statements)

References 34 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Soluble forms of membrane proteins are endogenous regulatory molecules that are included in the global immunological network and participate in the mechanisms of the immune response at various stages of its realization [4]. Currently, the prognostic, monitoring, and diagnostic significance of various soluble forms of differentiation molecules in immune-mediated diseases of different genesis, including COPD, is being studied [5–10].…”

Section: Introductionmentioning

confidence: 99%

Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD

Kubysheva

Soodaeva²,

Novikov

et al. 2018

Disease Markers

Self Cite

View full text Add to dashboard Cite

Soluble molecules of the major histocompatibility complex play an important role in the development of various immune-mediated diseases. However, there is not much information on the participation of these proteins in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of our work was to determine the content of soluble molecules of the major histocompatibility complex of classes I and II (sHLA-I and sHLA-II) in the exhaled breath condensate (EBC) and in the blood serum in patients with moderate to severe COPD during the exacerbation and stable phase. We investigated 105 patients (male) with COPD aged 46–67 and 21 healthy nonsmoking volunteers (male) comparable in age. The content of sHLA-I and sHLA-II molecules was studied using ELISA. We found an increase in the level of sHLA-I and sHLA-II molecules in EBC, as well as an enhancement in the serum content of sHLA-II in all the examined COPD patients compared to healthy nonsmoking volunteers. The revealed negative correlation between the serum concentration of sHLA-II and values of FEV1 and FEV1/FVC in all examined patients with COPD gives a possibility to consider the content of these proteins as an additional systemic marker of disease severity. The maximum endobronchial and serum concentrations of sHLA-I and sHLA-II were detected in patients with severe COPD during the exacerbation. The negative associations between the content of these molecules in EBC and serum and the parameters of lung function in patients with severe COPD were established. These findings suggest a pathogenetic role of sHLA-I and sHLA-II molecules in the mechanisms of the development and progression of local and systemic inflammation in COPD.

show abstract

Section: Introductionmentioning

confidence: 99%

Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD

Kubysheva

Soodaeva²,

Novikov

et al. 2018

Disease Markers

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition to the study of FRO, to identify the mechanisms of pathophysiological processes in COPD, special attention is paid to investigating the relationship between OS indicators and inflammation markers, such as cytokines and soluble differentiation molecules (sCD). Earlier in our works, we showed the role of several soluble forms of membrane molecules in the mechanisms of development of systemic and local inflammation in patients with this disease [ 3 , 4 , 25 , 26 ]. In particular, changes in soluble CD95 (sCD95) concentration in serum and EBC were detected in moderate and severe COPD patients during an exacerbation [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Differences in the Levels of Oxidative Status Marker and Soluble CD95 in Patients with Moderate to Severe COPD during an Exacerbation and a Stable Period

Soodaeva

Kubysheva

Klimanov

et al. 2021

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Studying the features of changes in markers of oxidative stress (OS) and inflammation indicators in COPD patients depending on the degree of bronchial obstruction is one of the priority directions for improving the prognosis and monitoring of the course of this pathology. We conducted a comparative investigation of changes in markers of OS and apoptosis at the systemic and local levels in patients with moderate to severe COPD during exacerbation and stable phase. 105 patients with COPD aged 46-67 and 21 healthy nonsmoking volunteers comparable in age were examined. COPD patients were divided into four groups: moderate COPD (GOLDII) during the exacerbation (GOLDIIex, n = 25 ) and in the stable phase (GOLDIIst, n = 27 ), severe COPD (GOLDIII) during the exacerbation (GOLDIIIex, n = 29 ), and in the stable phase (GOLDIIIst, n = 24 ). We studied the levels of such lipid peroxidation (LPO) products as diene conjugates (DC) and Schiff bases (SB) and parameters of induced chemiluminescence (Imax, total light sum-S, Imax/S) in blood serum, as well as sCD95 concentration in blood and exhaled breath condensate (EBC). The relationship between the values of the OS system indicators with sCD95, as well as with the parameters of lung function, was investigated. Multidirectional changes in OS indicator levels in COPD patients depending on the severity of obstructive airway disorders have been established. The maximum values of DC ( 0.26 ± 0.046 RU ), Imax ( 0.265 ± 0.19 RLU), and Imax/S ( 0.13 ± 0.05 ) were typical for patients with moderate COPD, while the highest SB level ( 5.7 ± 2.3 RU) was observed in severe COPD during an exacerbation. The exacerbation of the disease was characterized by an increase in DC concentration in both GOLDIIex ( 0.26 ± 0.046 RU) and GOLDIIIex ( 0.209 ± 0.02 RU) compared to the stable moderate and severe COPD ( 0.202 ± 0.028 RU and 0.19 ± 0.03 RU, respectively, p < 0.05 ). The established decrease in high values of DC, Imax, Imax/S, and sCD95 and an increase in SB concentration in GOLD III can serve as quantitative indicators of the prognosis of the severity of the disease. The serum concentration of sCD95 in GOLDIIex ( 366.4 ± 70.5 U/ml) and GOLDIIst ( 361.4 ± 72.8 U/ml) did not differ from the control group ( 393.7 ± 80.9 U/ml, p > 0.05 ). In patients with FEV 1 < 49 % during the exacerbation and stable phase, the serum levels of Imax/S ( 0.058 ± 0.01 and 0.062 ± 0.01 ) and sCD95 ( 318.2 ± 66.3 U/ml and 321.4 ± 42.5 U/ml) were lower than the values of healthy volunteers ( 0.08 ± 0.01 and 393.7 ± 80.9 U/ml, respectively, p < 0.05 ). A positive correlation between sCD95 concentration and airway obstruction degree in all examined COPD patients was established. The revealed numerous associations between sCD95 and OS marker levels in GOLDIII indicate a relationship between systemic radical stress and apoptosis processes both in the respiratory tract and the whole body under conditions of severe inflammation. The established correlations between the values of DC, Imax, and sCD95 in the blood serum and the lung function parameters in all studied patients allow us to consider these indicators as additional prognostic indicators of disease intensification. Our work results help clarify the participation and detail of FRO and apoptosis processes in developing pathophysiological features in moderate to severe COPD in different periods and, accordingly, improve the efficiency of diagnosis and treatment of the disease.

show abstract

Role of CD38/cADPR signaling in obstructive pulmonary diseases

Guedes

Dileepan

Jude

et al. 2020

Current Opinion in Pharmacology

View full text Add to dashboard Cite

Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients

Cited by 3 publications

References 34 publications

Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD

Soluble HLA-I and HLA-II Molecules Are Potential Prognostic Markers of Progression of Systemic and Local Inflammation in Patients with COPD

The Differences in the Levels of Oxidative Status Marker and Soluble CD95 in Patients with Moderate to Severe COPD during an Exacerbation and a Stable Period

Role of CD38/cADPR signaling in obstructive pulmonary diseases

Contact Info

Product

Resources

About