Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors

Drobotun, O.V.; Kolotilov, Мykola; Safonov, M V

doi:10.17721/fujcv9i1p63-69

Fr. Ukr. J. Chem.

2021

DOI: 10.17721/fujcv9i1p63-69

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Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors

O.V. Drobotun

Мykola Kolotilov

M V Safonov

Abstract: The aim of the study was to investigate the relationship between the vitamin D content, melatonin and the characteristics of pineal gland calcifications in patients with malignant tumors of the bones of the lower extremities. Vitamin D deficiency and pineal gland calcifications are observed in almost 100 % of patients with malignant tumors of the lower extremities’ bones. The high heterogeneity of calcifications and its dynamics during the treatment of patients may indicate the processes of their litholysis an… Show more

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Cited by 2 publications

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Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity

Drobotun,

Kolotilov,

Konovalenko

et al. 2024

PJS

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Background. Involved in many cascades of biological regulatory reactions, calcium, vitamin D and melatonin create a single metabolic pattern, maintaining the dynamic balance of bone tissue homeostasis. Nevertheless, these regulatory molecules, as structural and functional elements of bone tissue, play a crucial role in various cellular processes associated with oncogenesis and tumor progression. Synthetic peptide dalargin has wound healing, reparative, anti-inflammatory, antioxidant, immunomodulatory, anticarcinogenic, antitumor, and antimetastatic effects. The purpose of the study was to investigate the synthetic neuropeptide dalargin influence on the dynamics of vitamin D and melatonin blood serum levels as part of the treatment algorithm of patients with bone malignant tumors of the lower extremities and pelvis with polymorbidity and endoprosthetics. Materials and methods. The study included a control (first) group and a main (second) group of clinical observation of patients with malignant bone lesions. The serum melatonin content was measured by enzyme immunoassay using reagent kits (No. RE54021) from IBL-Hamburg GmbH (Germany). Serum levels of 25-hydroxycalciferol (25(OH)D) were determined by the immunochemiluminescent method on an ARCHITECT 25-OH Vitamin D Controls automatic analyzer. Results. In patients who received dalargin, more pronounced positive dynamics were established in the normalization of 25(ОН)D and melatonin levels, and there was no exacerbation of concomitant diseases. In contrast to the data of patients who did not receive dalargin, in the group where it was used, there were no relapses or metastases of the tumor during 14 months. A comparison of the 25(ОН)D and melatonin levels in patients 6–7 months and 12–14 months after treatment shows a tendency to recovery of indicators only in patients who were additionally treated with dalargin (p < 0.01). Conclusions. The study showed the possibility of using the neuropeptide dalargin to increase the effectiveness of the treatment of patients with primary malignant tumors with the burden of polymorbidity by influencing the levels of vitamin D and melatonin in the blood serum.

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Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity

Drobotun,

Kolotilov,

Konovalenko

et al. 2024

PJS

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show abstract

Scientifi c Research of the SI “Institute of Nuclear Medicine and Diagnostic Radiology of the National Academy of Medical Sciences Of Ukraine” in 2021: Artifi cial intellect and postprocessing

Dykan

Tarasyuk

Andrushchenko

2022

RDRT

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Researchers of the Institute performed the applied scientific research "To develop technology for digital processing of radiological diagnostic images based on elements of artificial intelligence in diffuse liver pathology in patients of different ages" (funded from the budget of NAMS of Ukraine) in conjunction with SI "Academician O.M. Lukyanova Institute of Pediatrics, Obstetrics and Gynecology of the National Academy of Medical Sciences of Ukraine ” together with the National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute ». When performing research, the most important results are: investigations in patients with nonalcoholic fatty liver disease demonstrated that the modern algorithm of radiological examination allows to determine not only the features of the structural structure of the body in the age aspect, in particular to characterize the fat component and information on the acoustic stiffness of the parenchyma, but is an important prerequisite for further monitoring of the effectiveness of diffuse liver disease treatment; methods for rapid diagnosis of diffuse liver disease based on the artificial intelligence elements application have been developed and implemented into the examination algorithm, which improves the level and speed of liver disease diagnosis at the stages of primary examination by 30% and allows to develop a differentiated approach in the application of other (high-cost) methods of radiological diagnostics. Protocols for post-processing of pancreatic diseases were developed together with the SI " O.O. Shalimov National Institute of Surgery and Transplantology of the National Academy of Medical Sciences of Ukraine”. Scientists of the Institute together with the Ukrainian Military Medical Academy took part in the development of the complex of radiological methods for the diagnosis of thoracic gunshot wounds, visualization of wound canals in case of gunshot and mine-explosive injuries.

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Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors

Cited by 2 publications

References 16 publications

Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity

Assessment of the dalargin effect on the level of vitamin D and melatonin in blood serum in patients with malignant bone tumors and polymorbidity

Scientifi c Research of the SI “Institute of Nuclear Medicine and Diagnostic Radiology of the National Academy of Medical Sciences Of Ukraine” in 2021: Artifi cial intellect and postprocessing

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