Relationship of Systolic Blood Pressure and Body Mass Index With Left Ventricular Mass and Mass Index in Adolescents

Öztürk, Cengiz; Aparcı, Mustafa; Karaduman, Mehmet; Balta, Şevket; Çelik, Turgay; İyisoy, Atilla

doi:10.1177/0003319715573102

Cited by 11 publications

(7 citation statements)

References 18 publications

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“…As previously reported, BMI is markedly associated with SBP and DBP (23). Obesity and salt intake are the most modifiable risk factors for high BP (24). The present study demonstrated that the SBP, MBP and DBP of middle-aged offspring are increased compared with those of other age groups, including more aged mice.…”

Section: Discussionsupporting

confidence: 82%

Effects of hereditary moderate high fat diet on metabolic performance and physical endurance capacity in C57BL/6 offspring

et al. 2018

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Obesity in pregnant women presents a risk to fetal health, leading to numerous metabolic syndromes and chronic inflammation risks. Previously, physical exercise was considered to be one of the primary treatments for obesity. However, the effect of fat consumption throughout the life cycle on physical endurance capacity remains unknown. A total of two groups of female mice (age, 6 weeks; C57BL/6J) were fed with a normal chow diet and a moderate high fat diet (MHFD), during pregnancy and lactation (8 weeks), with the offspring receiving the same diet as the mother. When filial mice were 8, 16 and 24 weeks old, they were tested for endurance, blood pressure (BP) and glucose tolerance, as well as adipose tissue infiltration and macrophage subtype. Compared with the control group, filial mice in MHFD groups exhibited increased BP and glucose levels and larger adipose cells (~4‑fold). During adolescence, the obese filial mice demonstrated increased endurance compared with controls. Endurance declines in middle and old age; the endurance of aged obese mice was 29% that of lean ones. In addition, body coordination and movement memory did not notably change. The expression of cluster of differentiation 68, one of the most reliable markers of macrophages, increased by 2.48‑fold, demonstrating that macrophages were recruited and underwent infiltration. In addition, increased tumor necrosis factor‑α and decreased interleukin‑10 expression demonstrated that infiltrated macrophages are polarized to the M1 state, which weakens physical endurance and resists type M2 macrophages, which exhibit repairing functions. In conclusion, hereditary MHFD weakens physical endurance and alters the metabolic characteristics of C57BL/6 offspring.

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Section: Discussionsupporting

confidence: 82%

Effects of hereditary moderate high fat diet on metabolic performance and physical endurance capacity in C57BL/6 offspring

et al. 2018

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“…Sympathetic overactivity is associated with structural LA remodeling that further induces LA functional and mechanical changes in MH patients. LA changes could partly be explained by increased BP values, but also by increased LVMI in MH and sustained hypertensive individuals …”

Section: Discussionmentioning

confidence: 99%

Masked Hypertension and Left Atrial Dysfunction: A Hidden Association

Tadić

Cuspidi

Radojkovic

et al. 2016

J of Clinical Hypertension

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3Masked hypertension (MH) is a clinical condition that indicates normal values of clinic blood pressure (BP) but elevated 24-hour BP. The purpose of this study was to investigate the relationship between MH and left atrial (LA) phasic function evaluated by both the volumetric and speckle tracking method. This cross-sectional study included 49 normotensive individuals, 50 patients with MH, and 70 untreated sustained hypertensive patients adjusted by age and sex. MH was diagnosed if clinic BP was normal and 24-hour BP was increased. LA reservoir function was lower in patients with MH and those with sustained hypertension compared with the normotensive group. LA conduit function gradually decreased, while LA booster pump function progressively increased, from normotension to sustained hypertension. Similar results were obtained by two-dimensional echocardiographic strain analysis. Independently of main clinic and echocardiographic characteristics, 24-hour systolic BP was associated with LA passive ejection fraction, LA total longitudinal strain, LA positive longitudinal strain, and LA stiffness index. In conclusion, MH is associated with impairment of LA phasic function and stiffness, and 24-hour systolic BP increment was closely related with LA remodeling. J Clin Hypertens (Greenwich). 2017;19:305-311. ª2016 Wiley Periodicals, Inc.At the beginning of the new millennium, the increasing use of ambulatory blood pressure (BP) monitoring (ABPM) has revealed the whole range of different BP patterns such as white-coat hypertension, sustained hypertension, nocturnal hypertension, and normotension. This was the reason for the introduction of 24-hour ABPM in guidelines regarding diagnosis of arterial hypertension and in everyday clinical practice. ABPM could provide true and prognostic information on BP variability in hypertensive patients.1 Recent analysis shows important prognostic value of BP variability, assessed by 24-hour ABPM, in white-coat hypertension among older patients. 2Thomas Pickering was the first to use the term masked hypertension (MH).3 Shortly thereafter investigations appeared that demonstrated a negative influence of MH on target organ damage, including cardiac hypertrophy, carotid atherosclerosis, and albuminuria. [4][5][6] These changes could explain the unfavorable prognosis of patients with MH and increased cardiovascular morbidity and mortality in this population. 7,8 Our recent meta-analysis included 776 patients with MH and showed that MH is associated with significant risk of left ventricular (LV) structural changes, primarily LV hypertrophy. 9Left atrial (LA) remodeling has not been sufficiently investigated in MH so far. Sincer and colleagues 10 provided data only on LA diameter, without any further details regarding LA volume (LAV) and phasic function, and they did not find a significant difference between normotensive control, sustained hypertensive, and MH patients. 10 In addition, LA remodeling could significantly contribute to increased morbidity and mortality in MH. In this context, rec...

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“…The relation between HB(g/dL) and GFR(cc/min/1.73 m 2 ) obtained in Rule2 confirmed in another study (14). The impact of age in blood pressure where obtained in Rule4 and The relation between MAP (mm Hg) and GFR (cc/min/1.73 m 2 ) where obtained in Rule6 and the relation between BSA (m 2 ) and systolic blood pressure were obtained in Rule7 approved in many studies (15). Most previous studies based on data mining techniques on patient’s data with kidney diseases used statistical or predictive methods.…”

Section: Discussionmentioning

confidence: 99%

Applying data mining techniques to determine important parameters in chronic kidney disease and the relations of these parameters to each other

Tahmasebian¹,

Ghazisaeedi²,

Langarizadeh³

et al. 2016

J Renal Inj Prev

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Introduction: Chronic kidney disease (CKD) includes a wide range of pathophysiological processes which will be observed along with abnormal function of kidneys and progressive decrease in glomerular filtration rate (GFR). According to the definition decreasing GFR must have been present for at least three months. CKD will eventually result in end-stage kidney disease. In this process different factors play role and finding the relations between effective parameters in this regard can help to prevent or slow progression of this disease. There are always a lot of data being collected from the patients’ medical records. This huge array of data can be considered a valuable source for analyzing, exploring and discovering information. Objectives: Using the data mining techniques, the present study tries to specify the effective parameters and also aims to determine their relations with each other in Iranian patients with CKD. Material and Methods: The study population includes 31996 patients with CKD. First, all of the data is registered in the database. Then data mining tools were used to find the hidden rules and relationships between parameters in collected data. Results: After data cleaning based on CRISP-DM (Cross Industry Standard Process for Data Mining) methodology and running mining algorithms on the data in the database the relationships between the effective parameters was specified. Conclusion: This study was done using the data mining method pertaining to the effective factors on patients with CKD.

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Relationship of Systolic Blood Pressure and Body Mass Index With Left Ventricular Mass and Mass Index in Adolescents

Cited by 11 publications

References 18 publications

Effects of hereditary moderate high fat diet on metabolic performance and physical endurance capacity in C57BL/6 offspring

Effects of hereditary moderate high fat diet on metabolic performance and physical endurance capacity in C57BL/6 offspring

Masked Hypertension and Left Atrial Dysfunction: A Hidden Association

Applying data mining techniques to determine important parameters in chronic kidney disease and the relations of these parameters to each other

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