Relationship of Sunnah Fasting and DNA Damage Among Mild Cognitive Impairment (MCI) Older Adults

Meramat, Asheila; Sharif, Razinah; Shahar, Suzana; Rajab, Nor Fadilah

doi:10.17576/jskm-2018-16si-29

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, IF also reduces body weight the same as CR, but the difference is that CR produces loss of muscle mass and adipose tissue whereas IF reduces the adipose tissues whilst preserving muscle mass both in human and animal models [ 11 ]. Many scientific studies have been carried out, finding that IF gives beneficial health improvement by prolonging the lifespan and prevention of other chronic diseases including cardiovascular diseases, different forms of cancer, diabetes, and renal diseases [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-fasting and a period of total fasting. This study aimed to determine the effects of IF on cognitive function among elderly individuals who practice IF who have mild cognitive impairment (MCI). A total of 99 elderly subjects with MCI of Malay ethnicity without any terminal illness were recruited from a larger cohort study, LRGS TUA. The subjects were divided into three groups, comprising those who were regularly practicing IF (r-IF), irregularly practicing IF (i-IF), and non-fasters (n-IF). Upon 36 months of follow-up, more MCI subjects in the r-IF group reverted to successful aging with no cognitive impairment and diseases (24.3%) compared to those in i-IF (14.2%) and n-IF groups (3.7%). The r-IF group’s subjects exhibited significant increment in superoxide dismutase (SOD) activity and reduction in body weight, levels of insulin, fasting blood glucose, malondialdehyde (MDA), C-reactive protein (CRP), and DNA damage. Moreover, metabolomics analysis showed that IF may modulate cognitive function via various metabolite pathways, including the synthesis and degradation of ketone bodies, butanoate metabolism, pyruvate metabolism, and glycolysis and gluconeogenesis pathways. Overall, the MCI-afflicted older adults who practiced IF regularly had better cognitive scores and reverted to better cognitive function at 36 months follow-up.

show abstract

Section: Introductionmentioning

confidence: 99%