“…Particularly important is the gating of afferent input to the spinal cord. While data from rodent models also suggest that post-synaptic inhibitory circuitry in the spinal cord dorsal horn is likely to be important for regulation of nociceptive threshold, particularly in the presence of injury, available electrophysiological, pharmacological and morphological data suggest that pre-synaptic inhibition of afferent input is the dominant mechanism for inhibition of somatosensory input into the CNS (Eccles et al, 1962, Eccles et al, 1963, Nishi et al, 1974, Mokha et al, 1983, Hiura et al, 1998, Reeve et al, 1998, Rudomin and Schmidt, 1999, Bae et al, 2000, Olave et al, 2002, Sutherland et al, 2002, Sokal and Chapman, 2003, Vesselkin et al, 2003, Weng and Dougherty, 2005). Virtually all dorsal root ganglion (DRG) neurons from rat respond to GABA with a rapidly activating, bicuculline-sensitive anion current (Oyelese et al, 1995, Zhu et al, 2012a).…”